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Acetylcholine Chloride (Miochol E)

Trade Name : Miochol E

Bausch & Lomb Incorporated

KIT

Strength

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Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Acetylcholine Chloride (Miochol E) which is also known as Miochol E and Manufactured by Bausch & Lomb Incorporated. It is available in strength of per ml. Read more

Acetylcholine Chloride (Miochol E) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials.  Click to know price.     Read less

Packaging and Delivery

Validated Cold Chain Shipment

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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About GNH

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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  • No data
  • (acetylcholine chloriden- intraocular solution)n- 20 mg/2 mL (10 mg/mL)
  • 1:100 with Electrolyte Diluentn n
  • FOR INTRAOCULARn- USE ONLY
  • Miochol-E (acetylcholine chloride intraocular solution) is a parasympathomimetic preparation for intraocular use. It is packaged in a blister pack containing one vial and one diluent ampule. The vial contains 20 mg acetylcholine chloride and 56 mg mannitol. The accompanying ampule contains 2 mL of a modified diluent of calcium chloride dihydrate, magnesium chloride hexahydrate, potassium chloride, sodium acetate trihydrate, and sterile water for injection.
  • The reconstituted liquid will be a sterile isotonic solution (275u2013330 milliosmoles/kg) containing 20 mg acetylcholine chloride (1:100 solution) and 2.8% mannitol. The pH range is 5.0u20138.2. Mannitol is used in the process of lyophilizing acetylcholine chloride, and is not considered an active ingredient.
  • The chemical name for acetylcholine chloride, CHClNO, is Ethanaminium, 2-(acetyloxy)-trimethyl-, chloride and is represented by the following chemical structure:
  • Acetylcholine is a naturally occurring neurohormone which mediates nerve impulse transmission at all cholinergic sites involving somatic and autonomic nerves. After release from the nerve ending, acetylcholine is rapidly inactivated by the enzyme acetylcholinesterase by hydrolysis to acetic acid and choline.
  • Direct application of acetylcholine to the iris will cause rapid miosis of short duration. Topical ocular instillation of acetylcholine to the intact eye causes no discernible response as cholinesterase destroys the molecule more rapidly than it can penetrate the cornea.
  • To obtain miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy, and other anterior segment surgery where rapid miosis may be required.
  • Miochol-E is contraindicated in persons with a known hypersensitivity to any component of this product.
  • DO NOT GAS STERILIZE. If blister or peelable backing is damaged or broken, sterility of the enclosed vial and ampule cannot be assured. Open under aseptic conditions only.
  • No data
  • Infrequent cases of corneal edema, corneal clouding, and corneal decompensation have been reported with the use of intraocular acetylcholine.
  • Adverse reactions have been reported rarely, which are indicative of systemic absorption. These include bradycardia, hypotension, flushing, breathing difficulties, and sweating.
  • To report SUSPECTED ADVERSE REACTIONS, contact Bausch + Lomb, a division of Valeant Pharmaceuticals North America LLC at 1-800-321-4576 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
  • Atropine sulfate (0.5 to 1 mg) should be given intramuscularly or intravenously and should be readily available to counteract possible overdosage. Epinephrine (0.1 to 1 mg subcutaneously) is also of value in overcoming severe cardiovascular or bronchoconstrictor responses.
  • Miochol-E (acetylcholine chloride intraocular solution) is instilled into the anterior chamber before or after securing one or more sutures.
  • Instillation should be gentle and parallel to the iris face and tangential to pupil border.
  • If there are no mechanical hindrances, the pupil starts to constrict in seconds and the peripheral iris is drawn away from the angle of the anterior chamber. Any anatomical hindrance to miosis must be released to permit the desired effect of the drug. In most cases, 0.5 to 2 mL produces satisfactory miosis. Note that the syringe filter supplied with Miochol-E has a priming volume of 0.6 mL (approximately).
  • In cataract surgery, use Miochol-E only after delivery of the lens.
  • Aqueous solutions of acetylcholine chloride are unstable. Prepare solution immediately before use. Do not use solution that is not clear and colorless. Discard any solution that has not been used.
  • STERILE UNLESS PACKAGE OPEN OR BROKEN
  • Discard the filter appropriately after use.
  • Do not reuse the syringe filter.
  • Do not aspirate and inject through the same filter.
  • Miochol-E(acetylcholine chloride intraocular solution)............................NDC 24208-539-20
  • One blister pack containing the following components:
  • One 0.2 micron sterile filter
  • Storage
  • Store at 4u00b0-25u00b0C (39u00b0-77u00b0F)
  • KEEP FROM FREEZING
  • KEEP OUT OF REACH OF CHILDREN
  • Manufactured for:
  • Manufactured by:
  • Miochol is a trademark of Bausch & Lomb Incorporated or its affiliates.
  • u00a9Bausch & Lomb Incorporated
  • Rev. 05/20179214904AB53920 u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0
  • NDC
  • Miochol-E n- (acetylcholine chloride n- intraocular solution)
  • 20 mg/2 mL (10 mg/mL)
  • Sterile
  • 1:100 with Electrolyten- Diluent
  • FOR INTRAOCULARn- USE ONLY
  • Rx Only
  • Contents:
  • BAUSCH + LOMB

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Comparator Sourcing for Clinical Trials

Comparator Sourcing for Clinical Trials

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Name Patient Supply

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