Adapalene (Differin)

Trade Name : Differin

GALDERMA LABORATORIES, L.P

CREAM

Strength 1 mg/g

ADAPALENE Retinoid [EPC],Retinoids [CS]

Delivery Process

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Disclaimer

Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Adapalene (Differin) which is also known as Differin and Manufactured by GALDERMA LABORATORIES, L.P. It is available in strength of 1 mg/g per ml. Read more

Adapalene (Differin) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials.  Click to know price.     Read less

Packaging and Delivery

Validated Cold Chain Shipment

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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About GNH

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

Read more
  • No data
  • DIFFERIN(adapalene) Cream, 0.1%, contains adapalene 0.1% in an aqueous cream emulsion consisting of carbomer 934P, cyclomethicone, edetate disodium, glycerin, methyl glucose sesquistearate, methylparaben, PEG-20 methyl glucose sesquistearate, phenoxyethanol, propylparaben, purified water, squalane, and trolamine.
  • The chemical name of adapalene is 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid. It is a white to off-white powder which is soluble in tetrahydrofuran, sparingly soluble in ethanol, and practically insoluble in water. The molecular formula is CHO and molecular weight is 412.53. Adapalene is represented by the following structural formula.
  • No data
  • DIFFERIN Cream is indicated for the topical treatment of acne vulgaris.
  • Two vehicle-controlled clinical studies were conducted in patients 12 to 30 years of age with mild to moderate acne vulgaris, in which DIFFERIN Cream was compared with its vehicle. Patients were instructed to apply their treatment medication once daily at bedtime for 12 weeks. In one study patients were provided with a soapless cleanser and were encouraged to refrain from using moisturizers. No other topical medications, other than DIFFERIN Cream, were to be applied to the face during the studies. DIFFERIN Cream was significantly more effective than its vehicle in the reduction of acne lesion counts. The mean percent reduction in lesion counts from baseline after treatment for 12 weeks are presented in the following table:
  • The trend in the Investigatoru2019s global assessment of severity supported the efficacy of DIFFERIN Cream when compared to the cream vehicle.
  • DIFFERIN Cream should not be administered to individuals who are hypersensitive to adapalene or any of the components in the cream vehicle.
  • No data
  • In controlled clinical trials, local cutaneous irritation was monitored in 285 acne patients who used DIFFERIN Cream once daily for 12 weeks. The frequency and severity of erythema, scaling, dryness, pruritus and burning were assessed during these studies. The incidence of local cutaneous irritation with DIFFERIN Cream from the controlled clinical studies is provided in the following table:
  • Other reported local cutaneous adverse events in patients who used DIFFERIN Cream once daily included: sunburn (2%), skin discomfort-burning and stinging (1%) and skin irritation (1%). Events occurring in less than 1% of patients treated with DIFFERIN Cream included: acne flare, dermatitis and contact dermatitis, eyelid edema, conjunctivitis, erythema, pruritus, skin discoloration, rash, and eczema.
  • DIFFERIN Cream is intended for cutaneous use only. If the medication is applied excessively, no more rapid or better results will be obtained and marked redness, scaling, or skin discomfort may occur. The acute oral toxicity of DIFFERIN Cream in mice and rats is greater than 10 mL/kg. Chronic ingestion of the drug may lead to the same side effects as those associated with excessive oral intake of Vitamin A.
  • DIFFERIN Cream should be applied to affected areas of the skin, once daily at nighttime. A thin film of the cream should be applied to the skin areas where acne lesions appear, using enough to cover the entire affected areas lightly. A mild transitory sensation of warmth or slight stinging may occur shortly after the application of DIFFERIN Cream.
  • DIFFERIN (adapalene) Cream, 0.1% is supplied in the following size:
  • 45 g tube u2013 0299-5915-45
  • Arrayn- Storage:
  • Marketed by:
  • GALDERMA LABORATORIES, L.P. Fort Worth, Texas 76177 USA
  • Manufactured by:
  • G Production Inc.
  • Baie d'Urfu00e9, QC
  • H9X 3S4 Canada
  • Made in Canada.
  • GALDERMA is a registered trademark.
  • www.differin.com
  • P50448-1
  • Revised: November 2011
  • Array
  • Differinn
  • (adapalene)
  • CREAM
  • 0.1%
  • NDC
  • GALDERMA
  • Array
  • For topical use only. Not for opthalmic, oral, or intravaginal use.
  • Store at controlled room temperature 68u00b0 to 77u00b0F (20u00b0-25u00b0C), excursions permitted between 59u00b0 and 86u00b0F (15u00b0-30u00b0C). Protect from freezing.
  • Usual dosage:
  • Contains:
  • Marketed by:
  • GALDERMA LABORATORIES, L.P.
  • Fort Worth, Texas 76177 USA
  • All trademarks are the property of their respective owners.
  • P50446-3

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