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Adenosine (Adenosine)

Trade Name : Adenosine

Hospira, Inc.

INJECTION, SOLUTION

Strength 3 mg/mL

ADENOSINE Adenosine Receptor Agonist [EPC],Adenosine Receptor Agonists [MoA]

Delivery Process

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Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Adenosine (Adenosine) which is also known as Adenosine and Manufactured by Hospira, Inc.. It is available in strength of 3 mg/mL per ml. Read more

Adenosine (Adenosine) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials.  Click to know price.     Read less

Packaging and Delivery

Validated Cold Chain Shipment

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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About GNH

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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  • No data
  • Adenosine Injection is indicated as an adjunct to thallium-201 myocardial perfusion scintigraphy in patients unable to exercise adequately.
  • Adenosine Injection, a pharmacologic stress agent, is indicated as an adjunct to thallium-201 myocardial perfusion scintigraphy in patients unable to exercise adequately ()
  • The recommended adenosine injection dose is 0.14 mg/kg/min infused over six minutes (total dose of 0.84 mg/kg) ().
  • Visually inspect adenosine injection for particulate matter and discoloration prior to administration. Do not administer adenosine injection if it contains particulate matter or is discolored.
  • There are no data on the safety or efficacy of alternative adenosine injection infusion protocols. The safety and efficacy of adenosine injection administered by the intracoronary route have not been established.
  • The nomogram displayed in was derived from the following general formula:
  • u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0n
  • Recommended dose is 0.14 mg/kg/min infused over six minutes as a continuous peripheral intravenous infusion (total dose of 0.84 mg/kg) ()
  • Adenosine Injection is supplied as 20 mL and 30 mL single-dose vials containing a sterile, nonpyrogenic, clear solution of adenosine 3mg/mL.
  • For Injection: 3 mg/mL in single-dose vials ()
  • Adenosine injection is contraindicated in patients with:
  • No data
  • Cardiac Arrest, Ventricular Arrhythmias, and Myocardial Infarction
  • Sinoatrial (SA) and Atrioventricular (AV) Nodal Block
  • Bronchoconstriction
  • Hypotension
  • Cerebrovascular Accidents
  • Seizures.n- Array
  • Hypersensitivity
  • Atrial Fibrillation
  • Hypertension
  • The following adverse reactions are discussed in more detail in other sections of the prescribing information:
  • Most common adverse reactions (incidence u226510%) are: flushing; chest discomfort; shortness of breath; headache; throat, neck or jaw discomfort; gastrointestinal discomfort; and dizziness ()
  • No data
  • 7.1n- 10
  • No data
  • The half-life of adenosine is less than 10 seconds and adverse reactions of adenosine injection usually resolve quickly when the infusion is discontinued, although delayed or persistent reactions have been observed. Methylxanthines, such as caffeine, aminophylline, and theophylline, are competitive adenosine receptor antagonists and theophylline has been used to terminate persistent adverse reactions. In clinical trials, theophylline (50 to 125 mg slow intravenous injection) was used to attenuate adenosine injection adverse reactions in approximately 2% of patients. Methylxanthine use is not recommended in patients who experience seizures in association with adenosine injection [].
  • Adenosine is an endogenous nucleoside and is chemically described as 6-amino-9-beta-D-ribofuranosyl-9-H-purine. Adenosine has the following structural formula:
  • The molecular formula for adenosine is CHNO and its molecular weight is 267.24.
  • Adenosine is a white, odorless crystalline powder. It is slightly soluble in water and practically insoluble in alcohol. Solubility increases by warming and lowering the pH of the solution.
  • Each Adenosine Injection vial contains a sterile, non-pyrogenic solution of adenosine 3 mg/mL and sodium chloride 9 mg/mL in water for injection, with pH between 4.5 and 7.5.
  • No data
  • Studies in animals have not been performed to evaluate adenosine's carcinogenic potential or potential effects on fertility. Adenosine was negative for genotoxic potential in the Salmonella (Ames Test) and Mammalian Microsome Assay.
  • Adenosine, however, like other nucleosides at millimolar concentrations present for several doubling times of cells in culture, is known to produce a variety of chromosomal alterations.
  • In two crossover comparative studies involving 319 subjects who could exercise (including 106 healthy volunteers and 213 patients with known or suspected coronary disease), adenosine injection and exercise thallium images were compared by blinded observers. The images were concordant for the presence of perfusion defects in 85.5% of cases by global analysis (patient by patient) and up to 93% of cases based on vascular territories.
  • In the two studies, 193 patients also had recent coronary arteriography for comparison (healthy volunteers were not catheterized). The sensitivity for detecting angiographically significant disease (u2265 50% reduction in the luminal diameter of at least one major vessel) was 64% for adenosine injection and 64% for exercise testing. The specificity was 54% for adenosine injection and 65% for exercise testing. The 95% confidence limits for adenosine injection sensitivity were 56% to 78% and for specificity were 37% to 71%.
  • Intracoronary Doppler flow catheter studies have demonstrated that a dose of intravenous adenosine injection of 0.14 mg/kg/min produces maximum coronary hyperemia (relative to intracoronary papaverine) in approximately 95% of cases within two to three minutes of the onset of the infusion. Coronary blood flow velocity returns to basal levels within one to two minutes of discontinuing the adenosine infusion.
  • How Supplied
  • Adenosine Injection, USP is supplied as 20 mL and 30 mL vials of sterile, nonpyrogenic, preservative-free, solution in normal saline:
  • Storage and Handling
  • Manufactured by: Gland Pharma Limited, Hyderabad 500043, India
  • Distributed by Hospira, Inc., Lake Forest, IL 60045 USA
  • LAB-1308-4.0
  • 20 mL Single-Dose Vial
  • NDC 0409-1932-01 Rx only
  • Adenosine Injection, USP
  • 60 mg/20 mL (3 mg/mL)
  • Sterile
  • For Intravenous Infusion Only
  • Hospira
  • 20 mL Single-Dose Vial
  • NDC 0409-1932-01 Rx only
  • Adenosine Injection, USP
  • 60 mg/20 mL (3 mg/mL)
  • Sterile
  • For Intravenous Infusion Only
  • Hospira
  • 30 mL Single-Dose Vial
  • NDC 0409-1932-02 Rx only
  • Adenosine Injection, USP
  • 90 mg/30 mL (3 mg/mL)
  • Sterile
  • For Intravenous Infusion Only
  • Hospira
  • 30 mL Single-Dose Vial
  • NDC 0409-1932-02 Rx only
  • Adenosine Injection, USP
  • 90 mg/30 mL (3 mg/mL)
  • Sterile
  • For Intravenous Infusion Only
  • Hospira

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