Alpha-1-Proteinase Inhibitor (Human) (Prolastin-C)
Trade Name : PROLASTIN-C
GRIFOLS USA, LLC
KIT, PLASMA DERIVATIVE
Storage/Handling:
Store Prolastin-C Liquid in your refrigerator at 2°C -8°C.
Uses of Alpha-1-Proteinase Inhibitor (Human) (Prolastin-C):
Used to treat alpha-1 antitrypsin deficiency (AAT deficiency)
Product Introduction:
Alpha-1-Proteinase Inhibitor (Human) (Prolastin-C) is a medication used to treat alpha-1 antitrypsin deficiency (AATD), a genetic condition that can lead to serious lung damage.
AATD occurs when someone inherits a faulty gene that prevents them from producing enough alpha-1 antitrypsin (AAT), a protein that protects the lungs from harmful enzymes. This lack of AAT can lead to early-onset emphysema, a chronic lung disease characterized by damaged air sacs, making it difficult to breathe.
Prolastin-C is a purified form of AAT extracted from human plasma. It acts as a replacement for the missing AAT in people with AATD. By providing additional AAT, Prolastin-C can help protect the lungs from the harmful enzymes and slow down the progression of emphysema.
Prolastin-C is primarily used for adults with severe AATD who have already developed lung damage due to emphysema. It's not a cure for AATD, but it can help manage symptoms and improve quality of life.
Prolastin-C is administered intravenously (through a vein) once a week. The exact dosage is determined by the doctor based on the patient's individual needs and response to treatment.
Delivery Process
Side Effects of Alpha-1-Proteinase Inhibitor (Human) (Prolastin-C):
Common side effects of alpha 1-proteinase inhibitor may include:
cold symptoms such as runny or stuffy nose, sneezing, cough, sore throat
headache
muscle or joint pain
weakness
flushing (sudden warmth, redness, or tingly feeling)
nausea or
bruising or bleeding where the medicine was injected
Alpha 1-proteinase inhibitor may cause serious side effects. Stop using alpha 1-proteinase inhibitor and call your doctor at once if you have:
wheezing, chest pain, trouble breathing
dizziness, severe headache
a seizure or
sudden numbness or weakness, slurred speech, problems with vision or balance.
You may feel faint during the injection. You may need to rest for a short time afterward.
Drug Interactions:
When taking Alpha-1-Proteinase Inhibitor (Human) (Prolastin-C), it's essential to be aware of potential drug interactions that can affect its effectiveness or increase the risk of side effects.
Always inform your doctor about all medications you are taking, including over-the-counter drugs and herbal supplements, before starting Prolastin-C treatment. This allows them to assess potential interactions and adjust your treatment plan accordingly.
How Alpha-1-Proteinase Inhibitor (Human) (Prolastin-C) Works:
Alpha-1-Proteinase Inhibitor (Human), known as Prolastin-C, operates as a treatment for alpha-1 antitrypsin deficiency (AATD). In individuals with AATD, there is a deficiency or malfunction of the protective protein alpha-1-proteinase inhibitor (A1PI), leading to an imbalance of enzymes called proteases that can damage lung tissue. Prolastin-C, administered intravenously, serves as a replacement therapy by providing purified A1PI derived from human plasma. This supplementation restores the balance of proteases, protecting lung tissue from degradation and slowing the progression of lung disease associated with AATD.
Prolastin-C therapy is designed to preserve lung function and improve respiratory health in affected individuals, offering a targeted approach to address the underlying cause of the genetic disorder.
Safety Instructions For Alpha-1-Proteinase Inhibitor (Human) (Prolastin-C):
ALCOHOL (Avoid)Limit or avoid alcohol consumption. Alcohol can increase the risk of side effects like dizziness and bleeding. Discuss your intake with your doctor and follow their recommendations. PREGNANCY (unsafe) Do not use Prolastin-C during pregnancy. The potential risks to the developing fetus outweigh any possible benefits. Explore alternative AAT augmentation methods with your doctor if needed. BREAST FEEDING (unsafe)Stop breastfeeding while taking Prolastin-C. The medication can pass through breast milk and harm your baby. Discuss safer feeding options with your doctor. DRIVING (caution) Refrain from driving or operating machinery after receiving Prolastin-C. Dizziness and other side effects can impair your judgment and coordination.
LIVER (cautious) Inform your doctor of any pre-existing liver conditions. Prolastin-C can affect liver function, and your doctor may need to adjust the dosage or monitor you closely. KIDNEY (cautious) Disclose any kidney problems to your doctor. Similar to the liver, kidneys can be impacted by Prolastin-C, requiring dosage adjustments or close monitoring. Children (not recommended) Prolastin-C is not approved for use in children. Its safety and effectiveness haven't been established in this age group.
Habit Forming:
No
Remember:
1. Prolastin-C is a purified form of human A1PI derived from plasma. Administered intravenously, it acts as replacement therapy, supplementing deficient or malfunctioning A1PI.
Prolastin-C is not a cure for AAT deficiency, but it can manage the condition and prevent further lung damage.
While primarily focused on lung protection, Prolastin-C therapy may offer benefits for liver health in individuals with AATD-related liver disease.
It's a lifelong treatment requiring regular injections.
It only works for AAT deficiency and not other lung diseases.
FAQs:
1. Are there potential side effects of Alpha-1-Proteinase Inhibitor therapy?
Like any medication, Alpha-1-Proteinase Inhibitor may have potential side effects. Common side effects include injection site reactions, fever, and respiratory tract infections. Serious allergic reactions are rare but possible.
2. Does Alpha-1-Proteinase Inhibitor therapy address liver complications?
While the primary focus is on lung protection, Alpha-1-Proteinase Inhibitor therapy may offer benefits for individuals with AATD-related liver disease. However, its effectiveness in treating liver complications varies.
3. Can Alpha-1-Proteinase Inhibitor be used during pregnancy?
Pregnant individuals or those planning to become pregnant should consult their healthcare provider before starting or continuing Alpha-1-Proteinase Inhibitor therapy, as its safety during pregnancy is not well-established.
4. Is Alpha-1-Proteinase Inhibitor therapy a cure for AATD?
Alpha-1-Proteinase Inhibitor therapy is not a cure for AATD but aims to manage and slow the progression of lung disease associated with the condition, preserving lung function.
5. How often should individuals undergo monitoring during Alpha-1-Proteinase Inhibitor therapy?
Regular monitoring, including lung function tests and medical check-ups, is essential during Alpha-1-Proteinase Inhibitor therapy to assess its effectiveness and make any necessary adjustments.
Product information is meant for
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Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"
GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Alpha-1-Proteinase Inhibitor (Human) (Prolastin-C) which is also known as PROLASTIN-C and Manufactured by GRIFOLS USA, LLC. It is available in strength of per ml. Read more
Alpha-1-Proteinase Inhibitor (Human) (Prolastin-C) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials. Click to know price. Read less
Packaging and Delivery
Validated Cold Chain Shipment
We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.
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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.
Read moreAbout GNH
We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.
We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.
Read more