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Amlodipine (Amlodipine)

Trade Name : Amlodipine

Macleods Pharmaceuticals Limited

TABLET

Strength 5 mg/1

AMLODIPINE BESYLATE Calcium Channel Antagonists [MoA],Dihydropyridine Calcium Channel Blocker [EPC],Dihydropyridines [CS]

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Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Amlodipine (Amlodipine) which is also known as Amlodipine and Manufactured by Macleods Pharmaceuticals Limited. It is available in strength of 5 mg/1 per ml. Read more

Amlodipine (Amlodipine) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials.  Click to know price.     Read less

Packaging and Delivery

Validated Cold Chain Shipment

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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About GNH

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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  • No data
  • Amlodipine besylate tabletsu00a0are a calcium channel blocker and may be used alone or in combination with other antihypertensive and antianginal agents for the treatment of: u2022Hypertension ()u00a0u00a0u00a0u00a0 o Amlodipine besylate tabletsu00a0are indicated for the tretament of hypertension, to lower blood pressure. Loweringu00a0bloodu00a0 pressure reduces the risk ofu00a0 u00a0u00a0u00a0u00a0u00a0u00a0u00a0 fatal and nonfatal cerdiovascular events, primarily strokes andu00a0myocardial infarctions.u2022Coronary Artery Disease () u00a0u00a0u00a0u00a0 o Chronic Stable Angina u00a0u00a0u00a0u00a0 o Vasospastic Angina (Prinzmetal's or Variant Angina) u00a0u00a0u00a0u00a0 o Angiographically Documented Coronary Artery Disease in patients without heart failure or an ejectionu00a0fraction < 40%.
  • u2022 Adult recommended starting dose: 5 mg once daily with maximum dose 10 mg once daily. () u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0 o Small, fragile, or elderly patients, or patients with hepatic insufficiency may be started on 2.5 mg once daily. () u2022 Pediatric starting dose: 2.5 mg to 5 mg once daily. ()n n Doses in excess of 5 mg daily have not been studied in pediatric patients. (2.2)
  • Tablets: 5 mg white to off white, capsule shaped, biconvex, uncoated tablets with 'ML' and '22' debossed, on one side and plain on other side
  • Tablets: 10 mg white to off white, round, biconvex, uncoated, tablets with 'ML' and '23' debossed, on one side and plain on the other side
  • u2022u00a0 5 mg and 10 mg Tablets ()
  • Amlodipine besylate tablets are contraindicated in patients with known sensitivity to amlodipine.
  • u2022 Known sensitivity to amlodipine ()
  • No data
  • Symptomatic hypotension is possible, particularly in patients with severe aortic stenosis. However,u00a0acute hypotension is unlikely.()
  • Worsening angina and acute myocardial infarction can develop after starting or increasing the dose of amlodipine besylate, particularly in patients with severe obstructive coronary artery disease. ()
  • Titrate slowly in patients with severe hepatic impairment. ()n
  • Most common adverse reactions to amlodipine isu00a0edema which occurred in a dose related manner. Other adverse experiences not dose related but reported with an incidence >1.0% areu00a0fatigue, nausea, abdominal pain, and somnolence. ()n n n n n
  • u2022Do not exceed dose greater than 20 mg daily of simvastatin.()
  • u2022 Pediatric: Effect on patients less than 6 years old is not known. () u2022 Geriatric: Start dosing at the low end of the dose range. ()
  • Overdosage might be expected to cause excessive peripheral vasodilation with marked hypotension and possibly a reflex tachycardia. In humans, experience with intentional overdosage of amlodipine besylate is limited. n Single oral doses of amlodipine maleate equivalent to 40 mg amlodipine/kg and 100 mg amlodipine/kg in mice and rats, respectively, caused deaths. Single oral amlodipine maleate doses equivalent to 4 or more mg amlodipine/kg or higher in dogs (11 or more times the maximum recommended human dose on a mg/m basis) caused a marked peripheral vasodilation and hypotension.n If massive overdose should occur, initiate active cardiac and respiratory monitoring. Frequent blood pressure measurements are essential. Should hypotension occur, provide cardiovascular support including elevation of the extremities and the judicious administration of fluids. If hypotension remains unresponsive to these conservative measures, consider administration of vasopressors (such as phenylephrine) with attention to circulating volume and urine output. Asu00a0 amlodipine besylate is highly protein bound, hemodialysis is not likely to be of benefit.
  • Amlodipine besylate USP is the besylate salt of amlodipine, a long-acting calcium channel blocker.n n Amlodipine besylate is chemically described as 3-Ethyl-5-methyl (u00b1)-2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate, monobenzenesulphonate. Its empirical formula is CHCINOu2022CHOS, and its structural formula is:
  • Amlodipine besylate USP is a white crystalline powder with a molecular weight of 567.1. It is slightly soluble in water and sparingly soluble in ethanol. Amlodipine besylate Tablets USP are formulated as white to off white tablets equivalent to 5 mg and 10 mg of amlodipine for oral administration. In addition to the active ingredient, amlodipine besylate, each tablet contains the following inactive ingredients: microcrystalline cellulose, dibasic calcium phosphate anhydrous, sodium starch glycolate, and magnesium stearate.
  • No data
  • Rats and mice treated with amlodipine maleate in the diet for up to two years, at concentrations calculated to provide daily dosage levels of 0.5, 1.25, and 2.5 amlodipine mg/kg/day, showed no evidence of a carcinogenic effect of the drug. For the mouse, the highest dose was, on a mg/m basis, similar to the maximum recommended human dose of 10 mg amlodipine/day. For the rat, the highest dose was, on a mg/m basis, about twice the maximum recommended human dose.n Mutagenicity studies conducted with amlodipine maleate revealed no drug related effects at either the gene or chromosome level.There was no effect on the fertility of rats treated orally with amlodipine maleate (males for 64 days and females for 14 days prior to mating) at doses up to 10 mg amlodipine/kg/day (8 times the maximum recommended human dose of 10 mg/day on a mg/m basis).________________________________________n Based on patient weight of 50 kg
  • No data
  • No data
  • No data
  • NDC 33342-015-10AMLODIPINE BESYLATE TABLETS 5 mgRx only 90 Tabletsu00a0
  • NDC 33342-016-10AMLODIPINE BESYLATE TABLETS 10u00a0mgRx only 90 Tabletsu00a0
  • NDC 33342-015-12AMLODIPINE BESYLATE TABLETS 5 mgRx only Unit dose package of 100
  • NDC 33342-016-12 AMLODIPINE BESYLATE TABLETS 10u00a0mgRx only Unit dose package of 100

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