Caspofungin Acetate (Cancidas)

Trade Name : CANCIDAS

Merck Sharp & Dohme Corp.

INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION

Strength 5 mg/mL

CASPOFUNGIN ACETATE Lipopeptides [CS],Echinocandin Antifungal [EPC]

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Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Caspofungin Acetate (Cancidas) which is also known as CANCIDAS and Manufactured by Merck Sharp & Dohme Corp.. It is available in strength of 5 mg/mL per ml. Read more

Caspofungin Acetate (Cancidas) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials.  Click to know price.     Read less

Packaging and Delivery

Validated Cold Chain Shipment

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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About GNH

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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  • No data
  • CANCIDAS is an echinocandin antifungal indicated in adults and pediatric patients (3 months of age and older) for:
  • Empirical therapy for presumed fungal infections in febrile, neutropenic patients. ()
  • Treatment of candidemia and the following infections: intra-abdominal abscesses, peritonitis and pleural space infections. ()
  • Treatment of esophageal candidiasis. ()
  • Treatment of invasive aspergillosis in patients who are refractory to or intolerant of other therapies. ()
  • Important Administration Instructions for All Patients ():
  • Dosage in Adults [18 years of age and older] ():
  • Dosage in Pediatric Patients [3 months to 17 years of age] ():
  • Dosage Adjustments in Patients with Hepatic Impairment ():
  • Reduce dosage for adult patients with moderate hepatic impairment (35 mg once daily, with a 70 mg loading dose on Day 1 where appropriate).
  • Dosage Adjustment in Patients Receiving Concomitant Inducers of Hepatic CYP Enzymes ():
  • CANCIDAS 50 mg is a white to off-white lyophilized cake or powder for reconstitution in a single-dose glass vial with a red aluminum band and a plastic cap. CANCIDAS 50-mg vial contains 50 mg of caspofungin equivalent to 55.5 mg of caspofungin acetate.
  • CANCIDAS 70 mg is a white to off-white lyophilized cake or powder for reconstitution in a single-dose glass vial with a yellow/orange aluminum band and a plastic cap. CANCIDAS 70-mg vial contains 70 mg of caspofungin equivalent to 77.7 mg of caspofungin acetate.
  • For Injection: 50 or 70 mg lyophilized powder (plus allowance for overfill) in a single-dose vial for reconstitution ()
  • CANCIDAS is contraindicated in patients with known hypersensitivity (e.g., anaphylaxis) to any component of this product .
  • CANCIDAS is contraindicated in patients with known hypersensitivity to any component of this product. ()
  • No data
  • Hypersensitivity
  • Hepatic Effects:
  • Elevated Liver Enzymes During Concomitant Use with Cyclosporine
  • The following serious adverse reactions are discussed in detail in another section of the labeling:
  • To report SUSPECTED ADVERSE REACTIONS, contact Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., at 1-877-888-4231 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
  • Adults:
  • Pediatric Patients:
  • No data
  • No data
  • Pregnancy:
  • Pediatric Use:
  • Hepatic Impairment:
  • In 6 healthy subjects who received a single 210-mg dose, no significant adverse reactions were reported. Multiple doses above 150 mg daily have not been studied. Caspofungin is not dialyzable.
  • In clinical trials, one pediatric patient (16 years of age) unintentionally received a single dose of caspofungin of 113 mg (on Day 1), followed by 80 mg daily for an additional 7 days. No clinically significant adverse reactions were reported.
  • CANCIDAS is a sterile, lyophilized product for intravenous (IV) infusion that contains a semisynthetic lipopeptide (echinocandin) compound synthesized from a fermentation product of CANCIDAS is an echinocandin antifungal that inhibits the synthesis of u03b2 (1,3)-D-glucan, an integral component of the fungal cell wall.
  • CANCIDAS (caspofungin acetate) is 1-[(4,5)-5-[(2-aminoethyl)amino]--(10,12-dimethyl-1-oxotetradecyl)-4-hydroxy-L-ornithine]-5-[(3)-3-hydroxy-L-ornithine] pneumocandin B diacetate (salt). CANCIDAS 50 mg contains 50 mg of caspofungin equivalent to 55.5 mg of caspofungin acetate. CANCIDAS 50 mg also contains: 39 mg sucrose, 26 mg mannitol, glacial acetic acid, and sodium hydroxide. CANCIDAS 70 mg contains 70 mg of caspofungin equivalent to 77.7 mg of caspofungin acetate. CANCIDAS 70 mg also contains 54 mg sucrose, 36 mg mannitol, glacial acetic acid, and sodium hydroxide. Caspofungin acetate is a hygroscopic, white to off-white powder. It is freely soluble in water and methanol, and slightly soluble in ethanol. The pH of a saturated aqueous solution of caspofungin acetate is approximately 6.6. The empirical formula is CHNOu22192CHOand the formula weight is 1213.42. The structural formula is:
  • No data
  • No data
  • No data
  • No data
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  • Distributed by: Merck Sharp & Dohme Corp., a subsidiary ofn Whitehouse Station, NJ 08889, USA
  • The trademarks depicted herein are owned by their respective companies.
  • Copyright u00a9 2001-2019 Merck Sharp & Dohme Corp., a subsidiary of n
  • All rights reserved.
  • uspi-mk0991-i-1902r012
  • NDC 0006-3822-10
  • Cancidasn- For Injection
  • 50 mg*
  • FOR INTRAVENOUS USE ONLY
  • *Vial contains 50 mg caspofunginequivalent to 55.5 mg caspofunginacetate. Reconstitute with 10.8 mLof diluent to obtain a concentrationof 5 mg/mL.n n Requires further dilution priorto infusion.
  • DO NOT USE DILUENTSCONTAINING DEXTROSE(u03b1-D-glucose)
  • Single-Dose Vialn n
  • NDC 0006-3823-10
  • Cancidasn- For Injection
  • 70 mg*
  • FOR INTRAVENOUS USE ONLY
  • *Vial contains 70 mg caspofunginequivalent to 77.7 mg caspofunginacetate. Reconstitute with 10.8 mLof diluent to obtain a concentrationof 7 mg/mL.n n Requires further dilution priorto infusion.
  • DO NOT USE DILUENTSCONTAINING DEXTROSE(u03b1-D-glucose)
  • Single-Dose Vialn n

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