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Ciprofloxacin Hydrochloride (Ciloxan)

Trade Name : CILOXAN

Alcon Laboratories, Inc.

OINTMENT

Strength 3 mg/g

CIPROFLOXACIN HYDROCHLORIDE Quinolone Antimicrobial [EPC],Quinolones [CS]

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Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Ciprofloxacin Hydrochloride (Ciloxan) which is also known as CILOXAN and Manufactured by Alcon Laboratories, Inc.. It is available in strength of 3 mg/g per ml. Read more

Ciprofloxacin Hydrochloride (Ciloxan) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials.  Click to know price.     Read less

Packaging and Delivery

Validated Cold Chain Shipment

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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About GNH

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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  • No data
  • CILOXAN (ciprofloxacin ophthalmic ointment) 0.3% is a synthetic, sterile, multiple dose, antimicrobial for topical use. Ciprofloxacin is a fluoroquinolone antibacterial. It is available as the monohydrochloride monohydrate salt of 1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid. Ciprofloxacin is a faint to light yellow crystalline powder with a molecular weight of 385.82. Its empirical formula is CHFNOu2022HClu2022HO and its chemical structure is as follows:
  • Ciprofloxacin differs from other quinolones in that it has a fluorine atom at the 6-position, a piperazine moiety at the 7-position, and a cyclopropyl ring at the 1-position.
  • Each gram of CILOXANn- (ciprofloxacin ophthalmic ointment) 0.3% contains: Active: n- Inactives:
  • Systemic Absorption:
  • Microbiology: n- in vitrou00a0
  • Ciprofloxacin has been shown to be active against most strains of the following microorganisms bothand in clinical infections (see INDICATIONS AND USAGE section).
  • Aerobic gram-positive microorganisms:n- Staphylococcus aureusu00a0n- Staphylococcus epidermidisu00a0n- Streptococcus pneumoniaen- Streptococcus
  • Aerobic gram-negative microorganisms:n- Haemophilus influenzae
  • The following data are available; . The safety and effectiveness of ciprofloxacin in treating conjunctivitis due to these microorganisms have not been established in adequate and well controlled trials.
  • The following organisms are considered susceptible when evaluated using systemic breakpoints. However, a correlation between the systemic breakpoint and ophthalmological efficacy has not been established. Ciprofloxacin exhibits minimal inhibitory concentrations (MICu2019s) of 1 mcg/mL or less (systemic susceptible breakpoint) against most (greater than or equal to 90%) strains of the following ocular pathogens.
  • Aerobic gram-positive microorganisms:n- Bacillus n- Corynebacterium n- Staphylococcus haemolyticusn n- Staphylococcus hominis
  • Aerobic gram-negative microorganisms:n- Acinetobacter calcoaceticusn n- Enterobacter aerogenesn n- Escherichia colin n- Haemophilus parainfluenzaen n- Klebsielle pneumoniaen n- Moraxella catarrhalisn n- Neisseria gonorrhoeaen n- Proteus mirabilisn n- Pseudomonas aeruginosan n- Serratia marcesens
  • Most strains of and some strains of are resistant to ciprofloxacin as are most anaerobic bacteria, including and .
  • The minimal bactericidal concentration (MBC) generally does not exceed the minimal inhibitory concentration (MIC) by more than a factor of 2. Resistance to ciprofloxacin usually develops slowly (multiple-step mutation). Ciprofloxacin does not cross-react with other antimicrobial agents such as beta-lactams or aminoglycosides; therefore, organisms resistant to these drugs may be susceptible to ciprofloxacin. Organisms resistant to ciprofloxacin may be susceptible to beta-lactams or aminoglycosides.
  • Clinical Studies:
  • CILOXAN (ciprofloxacin ophthalmic ointment) 0.3% is indicated for the treatment of bacterial conjunctivitis caused by susceptible strains of the microorganisms listed below:
  • Gram-Positive:n- Staphylococcus aureusn n- Staphylococcus epidermidisn n- Streptococcus pneumoniaen n- Streptococcus
  • Gram-Negative:n- Haemophilus influenzae
  • A history of hypersensitivity to ciprofloxacin or any other component of the medication is a contraindication to its use. A history of hypersensitivity to other quinolones may also contraindicate the use of ciprofloxacin.
  • FOR TOPICAL OPHTHALMIC USE ONLY.NOT FOR INJECTION INTO THE EYE.Serious and occasionally fatal hypersensitivity (anaphylactic) reactions, some following the first dose, have been reported in patients receiving systemic quinolone therapy. Some reactions were accompanied by cardiovascular collapse, loss of consciousness, tingling, pharyngeal or facial edema, dyspnea, urticaria, and itching. Only a few patients had a history of hypersensitivity reactions. Serious anaphylactic reactions require immediate emergency treatment with epinephrine and other resuscitation measures, including oxygen, intravenous fluids, intravenous antihistamines, corticosteroids, pressor amines and airway management, as clinically indicated.n
  • No data
  • The following adverse reactions (incidences) were reported in 2% of the patients in clinical studies for CILOXAN (ciprofloxacin ophthalmic ointment) 0.3%: discomfort and keratopathy. Other reactions associated with ciprofloxacin therapy occurring in less than 1% of patients included allergic reactions, blurred vision, corneal staining, decreased visual acuity, dry eye, edema, epitheliopathy, eye pain, foreign body sensation, hyperemia, irritation, keratoconjunctivitis, lid erythema, lid margin hyperemia, photophobia, pruritus, and tearing. Systemic adverse reactions related to ciprofloxacin therapy occurred at an incidence below 1% and included dermatitis, nausea and taste perversion.
  • Apply a u00bd inch ribbon into the conjunctival sac three times a day on the first two days, then apply a u00bd inch ribbon two times a day for the next five days.
  • How Supplied:
  • 3.5 g u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a00065-0654-35
  • Storage:
  • Ciprofloxacin and related drugs have been shown to cause arthropathy in immature animals of most species tested following oral administration. However, a one month topical ocular study using immature Beagle dogs did not demonstrate any articular lesions.
  • ntttttttu00a9 2002, 2008, 2016, 2018 Novartisntttttt
  • Distributed by:
  • Alconn A Novartis company
  • T2018-36n April 2018
  • NDC
  • Alconn
  • Ciloxann
  • (ciprofloxacin ophthalmic ointment) 0.3%
  • Sterile 3.5 g Net Wt.

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