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Conjugated Estrogens (Premarin)

Trade Name : Premarin

Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc.

INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION

Strength 25 mg/5mL

ESTROGENS, CONJUGATED Estrogen [EPC],Estrogen Receptor Agonists [MoA],Estrogens, Conjugated (USP) [CS]

Delivery Process

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Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Conjugated Estrogens (Premarin) which is also known as Premarin and Manufactured by Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc.. It is available in strength of 25 mg/5mL per ml. Read more

Conjugated Estrogens (Premarin) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials.  Click to know price.     Read less

Packaging and Delivery

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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About GNH

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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  • No data
  • Specially prepared for Intravenous & Intramuscular use
  • Rx only
  • No data
  • Premarin Intravenous (conjugated estrogens, USP) for injection contains a mixture of conjugated estrogens obtained exclusively from natural sources, occurring as the sodium salts of water-soluble estrogen sulfates blended to represent the average composition of materials derived from pregnant mares' urine. It is a mixture of sodium estrone sulfate and sodium equilin sulfate. It contains as concomitant components, as sodium sulfate conjugates, 17u03b1-dihydroequilin, 17u03b1-estradiol, and 17u03b2-dihydroequilin.
  • Each Secule vial contains 25 mg of conjugated estrogens, USP, in a sterile lyophilized cake which also contains lactose 200 mg, sodium citrate 12.2 mg, and simethicone 0.2 mg. The pH is adjusted with sodium hydroxide or hydrochloric acid. The reconstituted solution is suitable for intravenous or intramuscular injection.
  • Endogenous estrogens are largely responsible for the development and maintenance of the female reproductive system and secondary sexual characteristics. Although circulating estrogens exist in a dynamic equilibrium of metabolic interconversions, estradiol is the principal intracellular human estrogen and is substantially more potent than its metabolites, estrone and estriol, at the receptor level. The primary source of estrogen in normally cycling adult women is the ovarian follicle, which secretes 70 to 500 mcg of estradiol daily, depending on the phase of the menstrual cycle. After menopause, most endogenous estrogen is produced by conversion of androstenedione, secreted by the adrenal cortex, to estrone in the peripheral tissues. Thus, estrone and the sulfate-conjugated form, estrone sulfate, are the most abundant circulating estrogen in postmenopausal women.
  • Estrogens act through binding to nuclear receptors in estrogen-responsive tissues. To date, two estrogen receptors have been identified. These vary in proportion from tissue to tissue.
  • Circulating estrogens modulate the pituitary secretion of the gonadotropins, luteinizing hormone (LH) and follicle stimulating hormone (FSH), through a negative feedback mechanism. Estrogens act to reduce the elevated levels of these gonadotropins seen in postmenopausal women.
  • No data
  • Premarin Intravenous (conjugated estrogens, USP) for injection is indicated in the treatment of abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology.
  • Premarin Intravenous is indicated for short-term use only, to provide a rapid and temporary increase in estrogen levels.
  • Premarin Intravenous therapy should not be used in individuals with any of the following conditions:
  • See .
  • Premarin Intravenous for injection is indicated for short-term use. However, warnings, precautions and adverse reactions associated with oral Premarin treatment should be taken into account.
  • No data
  • See , , and .
  • Premarin Intravenous for injection is indicated for short-term use. However, the warnings, precautions and adverse reactions associated with oral Premarin treatment should be taken into account.
  • The following adverse reactions have been identified during post-approval use of oral or intravenous Premarin. Because these reactions are reported voluntarily from a population of uncertain size, it is not possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
  • Genitourinary system
  • Breasts
  • Cardiovascular
  • Gastrointestinal
  • Skin
  • Eyes
  • Central Nervous System
  • Miscellaneous
  • Overdosage of estrogen may cause nausea, vomiting, breast tenderness, abdominal pain, drowsiness and fatigue, and withdrawal bleeding may occur in women. Treatment of overdose consists of discontinuation of Premarin therapy with institution of appropriate symptomatic care.
  • For treatment of abnormal uterine bleeding due to hormonal imbalance in the absence of organic pathology:
  • One 25 mg injection, intravenously or intramuscularly. Intravenous use is preferred since more rapid response can be expected from this mode of administration. Repeat in 6 to 12 hours if necessary. The use of Premarin Intravenous for injection does not preclude the advisability of other appropriate measures.
  • One should adhere to the usual precautionary measures governing intravenous administration. Injection should be made SLOWLY to obviate the occurrence of flushes.
  • Infusion of Premarin Intravenous for injection with other agents is not generally recommended. In emergencies, however, when an infusion has already been started it may be expedient to make the injection into the tubing just distal to the infusion needle. If so used, compatibility of solutions must be considered.
  • Premarin Intravenous is compatible with normal saline, dextrose, and invert sugar solutions. n
  • No data
  • NDC 0046-0749-05u2013Each package provides one SECULE vial containing 25 mg of conjugated estrogens, USP, for injection (also lactose 200 mg, sodium citrate 12.2 mg, and simethicone 0.2 mg). The pH is adjusted with sodium hydroxide or hydrochloric acid.
  • Premarin Intravenous (conjugated estrogens, USP) for injection is prepared by cryodesiccation.
  • SECULE-Registered trademark to designate a vial containing an injectable preparation in dry form.
  • Premarin Intravenous
  • Read this PATIENT INFORMATION which describes the benefit and major risks of your treatment, as well as how and when treatment should be used. This information does not take the place of talking to your healthcare provider about your medical condition or your treatment.
  • What is Premarin Intravenous?
  • Premarin Intravenous is a medicine that contains a mixture of estrogen hormones.
  • Premarin Intravenous is used to:
  • Who should not use Premarin Intravenous?
  • Premarin Intravenous should not be used if you:
  • Tell your healthcare provider:
  • What are the possible side effects of Premarin Intravenous?
  • Premarin Intravenous is for short-term use only. However, the risks associated with oral Premarin treatment should be taken into account.
  • Side effects are grouped by how serious they are and how often they happen when you are treated.
  • Serious, but less common side effects include:
  • Call your healthcare provider right away if you get any of the following warning signs or any other unusual symptoms that concern you:
  • Less serious, but common side effects include:
  • These are not all the possible side effects of Premarin. For more information, ask your healthcare provider or pharmacist for advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
  • What can I do to lower my chances of getting a serious side effect with Premarin Intravenous?
  • General information about the safe and effective use of Premarin Intravenous
  • Medicines are sometimes prescribed for conditions that are not mentioned in patient information leaflets. Do not use Premarin Intravenous for conditions for which it was not prescribed. Do not give Premarin Intravenous to other people, even if they have the same symptoms you have. It may harm them. n
  • This leaflet provides a summary of the most important information about Premarin Intravenous. If you would like more information, talk with your healthcare provider or pharmacist. You can ask for information about Premarin Intravenous that is written for health professionals. To report SUSPECTED ADVERSE REACTIONS, contact Pfizer at 1-800-438-1985 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
  • What are the ingredients in Premarin IV?
  • Premarin Intravenous for injection contains a mixture of conjugated estrogens, which are a mixture of sodium estrone sulfate and sodium equilin sulfate and other components including sodium sulfate conjugates: 17u03b1-dihydroequilin, 17u03b1-estradiol, and 17u03b2-dihydroequilin. Premarin Intravenous for injection also contains lactose, sodium citrate, simethicone, and sodium hydroxide or hydrochloric acid in dry form. The reconstituted solution is suitable for intravenous or intramuscular injection.
  • Each Premarin Intravenous (conjugated estrogens, USP) for injection package provides 25 mg of conjugated estrogens, USP, in dry form for intravenous or intramuscular use.
  • LAB-0505-4.0 Rev 09/2018
  • Premarin Intravenous (conjugated estrogens, USP) for injection
  • Rx only
  • Read this PATIENT INFORMATION which describes the benefit and major risks of your treatment, as well as how and when treatment should be used. This information does not take the place of talking to your healthcare provider about your medical condition or your treatment.
  • What is Premarin Intravenous?
  • Premarin Intravenous is a medicine that contains a mixture of estrogen hormones.
  • Premarin Intravenous is used to:
  • Who should not use Premarin Intravenous?
  • Premarin Intravenous should not be used if you:
  • Tell your healthcare provider:
  • What are the possible side effects of Premarin Intravenous?
  • Premarin Intravenous is for short-term use only. However, the risks associated with oral Premarin treatment should be taken into account.
  • Side effects are grouped by how serious they are and how often they happen when you are treated.
  • Serious, but less common side effects include:
  • Call your healthcare provider right away if you get any of the following warning signs or any other unusual symptoms that concern you:
  • Less serious, but common side effects include:
  • These are not all the possible side effects of Premarin. For more information, ask your healthcare provider or pharmacist for advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
  • What can I do to lower my chances of getting a serious side effect with Premarin Intravenous?
  • General information about the safe and effective use of Premarin Intravenous
  • Medicines are sometimes prescribed for conditions that are not mentioned in patient information leaflets. Do not use Premarin Intravenous for conditions for which it was not prescribed. Do not give Premarin Intravenous to other people, even if they have the same symptoms you have. It may harm them. n
  • This leaflet provides a summary of the most important information about Premarin Intravenous. If you would like more information, talk with your healthcare provider or pharmacist. You can ask for information about Premarin Intravenous that is written for health professionals. To report SUSPECTED ADVERSE REACTIONS, contact Pfizer at 1-800-438-1985 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
  • What are the ingredients in Premarin IV?
  • Premarin Intravenous for injection contains a mixture of conjugated estrogens, which are a mixture of sodium estrone sulfate and sodium equilin sulfate and other components including sodium sulfate conjugates: 17u03b1-dihydroequilin, 17u03b1-estradiol, and 17u03b2-dihydroequilin. Premarin Intravenous for injection also contains lactose, sodium citrate, simethicone, and sodium hydroxide or hydrochloric acid in dry form. The reconstituted solution is suitable for intravenous or intramuscular injection.
  • Each Premarin Intravenous (conjugated estrogens, USP) for injection package provides 25 mg of conjugated estrogens, USP, in dry form for intravenous or intramuscular use.
  • LAB-0518-3.0 Rev 09/2018
  • SECULE vial
  • Refrigerate at 2u00b0 to 8u00b0C (36u00b0 to 46u00b0F).
  • NDC 0046-0749-05Rx only
  • Pfizer
  • Premarin Intravenous(conjugated estrogens, USP) for injectionPrepared by cryodesiccation.
  • 25 mg
  • To be reconstituted with Sterile Water for Injection, USP.See package circular for reconstitutioninstructions and complete directions for use.Distributed by Wyeth Pharmaceuticals IncA subsidiary of Pfizer Inc
  • 14513800cod. 229845
  • PfizerNDC 0046-0749-05Rx only
  • Premarin Intravenous(conjugated estrogens,USP) for injection
  • 25 mg
  • Prepared by cryodesiccation.
  • This package provides oneSECULE vial containing 25 mgof conjugated estrogens, USP,for injection.

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