Trade Name: cyanocobalamin

Following information is meant for : Wholesalers, Suppliers, Exporters, Doctors, CROs, Comparator Supplies, Hospitals, MOH Tender Supplies, Generic, Brand, Cooperate Sourcing, India, Institutional Buyers.

Manufacturer: Somerset Therapeutics, LLC

Presentation: INJECTION, HUMAN PRESCRIPTION DRUG

Strength: 1000 ug/mL

Storage and handling

CYANOCOBALAMIN Vitamin B 12 [CS],Vitamin B12 [EPC]

Disclaimer:
  1. These products are NOT FOR SALE in US territories. We offer them for Exports outside of US Territories to Trade Professionals or patients with a valid prescription.
  2. Trademark shown are property of their respective owners and GNH India does not lay any claim on them.
  3. Read more
  • No data
  • Cyanocobalamin Injection, USP is a sterile solution of cyanocobalamin for intramuscular or subcutaneous use.
  • Each mL contains 1,000 mcg cyanocobalamin; sodium chloride 0.9%; benzyl alcohol 1.5%; Water for Injection q.s.; Hydrochloric acid and/or sodium hydroxide for pH adjustment if necessary (4.5-7.0).
  • Cyanocobalamin appears as dark, red crystals or as an amorphous or crystalline, red powder. It is very hygroscopic in the anhydrous form, and sparingly soluble in water (1:80). It is stable to autoclaving for short periods at 121u00b0C. The Vitamin B coenzymes are very unstable in light.
  • The chemical name is 5,6-dimethyl-benzimidazolyl cyanocobamide. The cobalt content is 4.34%. The structural formula is represented below:
  • Vitamin B is essential to growth, cell reproduction, hematopoiesis, nucleoprotein and myelin synthesis.
  • Cyanocobalamin is quantitatively and rapidly absorbed from intramuscular and subcutaneous sites of injection; the plasma level of the compound reaches its peak within one hour after intramuscular injection.u00a0 Absorbed Vitamin B is transported via specific B binding proteins, transcobalamin I and II to the various tissues. The liver is the main organ for Vitamin B storage.
  • Within 48 hours after injection of 100 or 1,000 mcg of Vitamin B, 50 to 98% of the injected dose may appear in the urine. The major portion is excreted within the first eight hours. Intravenous administration results in even more rapid excretion with little opportunity for liver storage.
  • Gastrointestinal absorption of Vitamin B depends on the presence of sufficient intrinsic factor and calcium ions. Intrinsic factor deficiency causes pernicious anemia, which may be associated with subacute combined degeneration of the spinal cord. Prompt parenteral administration of Vitamin B prevents progression of neurologic damage.
  • The average diet supplies about 5 to 15 mcg/day of Vitamin B in a protein-bound form that is available for absorption after normal digestion. Vitamin B is not present in foods of plant origin, but is abundant in foods of animal origin. In people with normal absorption, deficiencies have been reported only in strict vegetarians who consume no products of animal origin (including no milk products or eggs).
  • Vitamin B is bound to intrinsic factor during transit through the stomach; separation occurs in the terminal ileum in the presence of calcium, and Vitamin B enters the mucosal cell for absorption. It is then transported by the transcobalamin binding proteins. A small amount (approximately 1% of the total amount ingested) is absorbed by simple diffusion, but this mechanism is adequate only with very large doses. Oral absorption is considered too undependable to rely on in patients with pernicious anemia or other conditions resulting in malabsorption of Vitamin B.
  • Cyanocobalamin is the most widely used form of Vitamin B, and has hematopoietic activity apparently identical to that of the antianemia factor in purified liver extract. Hydroxocobalamin is equally as effective as cyanocobalamin, and they share the cobalamin molecular structure.
  • Cyanocobalamin is indicated for Vitamin B deficiencies due to malabsorption which may be associated with the following conditions:
  • Addisonian (pernicious) anemia
  • Gastrointestinal pathology, dysfunction, or surgery, including gluten enteropathy or sprue, small bowel bacterial overgrowth, total or partial gastrectomy
  • Fish tapeworm infestation
  • Malignancy of pancreas or bowel
  • Folic acid deficiency
  • It may be possible to treat the underlying disease by surgical correction of anatomic lesions leading to small bowel bacterial overgrowth, expulsion of fish tapeworm, discontinuation of drugs leading to vitamin malabsorption (see ), use of a gluten-free diet in nontropical sprue, or administration of antibiotics in tropical sprue. Such measures remove the need for long-term administration of cyanocobalamin.
  • Requirements of Vitamin B in excess of normal (due to pregnancy, thyrotoxicosis, hemolytic anemia, hemorrhage, malignancy, hepatic and renal disease) can usually be met with oral supplementation.
  • Cyanocobalamin injection is also suitable for the Vitamin B absorption test (Schilling test).
  • Sensitivity to cobalt and/or Vitamin B is a contraindication.
  • This product contains aluminum that may be toxic. Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which contain aluminum.
  • Research indicates that patients with impaired kidney function, including premature neonates, who receive parenteral levels of aluminum at greater than 4 to 5 mcg/kg/day accumulate aluminum at levels associated with central nervous system and bone toxicity. Tissue loading may occur at even lower rates of administration.
  • Patients with early Leber's disease (hereditary optic nerve atrophy) who were treated with cyanocobalamin suffered severe and swift optic atrophy.
  • Hypokalemia and sudden death may occur in severe megaloblastic anemia which is treated intensely.
  • Anaphylactic shock and death have been reported after parenteral Vitamin B administration. An intradermal test dose is recommended before cyanocobalamin injection is administered to patients suspected of being sensitive to this drug.
  • This product contains benzyl alcohol.n- Benzyl alcohol has been reported to be associated with a fatal ''Gasping Syndrome'' in premature infants.
  • No data
  • Generalized
  • Anaphylactic shock and death have been reported with administration of parenteral Vitamin B (see ).
  • Cardiovascular
  • Pulmonary edema and congestive heart failure early in treatment; peripheral vascular thrombosis.
  • Hematological
  • Polycythemia vera.
  • Gastrointestinal
  • Mild transient diarrhea.
  • Dermatological
  • Itching; transitory exanthema.
  • Miscellaneous
  • Feeling of swelling of entire body.
  • No overdosage has been reported with this drug.
  • Avoid using the intravenous route. Use of this product intravenously will result in almost all of the vitamin being lost in the urine.
  • 1 mL multiple dose vial, packaged 25 vials per tray.
  • 10 mL multiple dose vial, packaged as;
  • - 10 vials per tray and
  • - 25 vials per tray.
  • Store at 20u00b0 to 25u00b0C (68u00b0 to 77u00b0F) [see USP Controlled Room Temperature].
  • PROTECT FROM LIGHT
  • Use only if solution is clear and seal intact.
  • For Product Inquiry call 1-800-417-9175
  • Manufactured for:
  • Somerset Therapeutics, LLC
  • Hollywood, FL 33024
  • Made in India
  • Code No.: KR/DRUGS/KTK/28/289/97
  • ST-CYC/P/05
  • Revised: 09/2020
  • Cyanocobalamin Injection, USP
  • 1 mL Container Label
  • NDC 70069--01
  • Cyanocobalamin Injection, USP
  • 1 mL Carton Label
  • NDC 70069--10
  • Cyanocobalamin Injection, USP
  • 10 mL Container Label
  • NDC 70069--01
  • Cyanocobalamin Injection, USP
  • 10 mL Carton Label u2013 Pack of 25's
  • NDC 70069--25
  • Cyanocobalamin Injection, USP
  • 10 mL Carton Label u2013 Pack of 10's
  • NDC 70069--10

Ask for Quote

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler, Supplier, Exporters from India of cyanocobalamin (cyanocobalamin) which is also known as cyanocobalamin and Manufactured by Somerset Therapeutics, LLC. It is available in strength of 1000 ug/mL.

cyanocobalamin (cyanocobalamin) is supplied for Tenders, Emergency imports, Un - licensed, Specials, Orphan drug, Name patient line, RLD supplies, Reference listed drugs, Comparator Drug, Bio-Similar, Innovator samples, For Clinical trials. Click to know price.

Browse Our Services And Processes

Name Patient Supply

Name Patient Supply

Validated Cold Chain Shipment

Validated Cold Chain Shipment

Comparator Sourcing for Clinical Trials

Comparator Sourcing for Clinical Trials

Our Process - The Gnh Way

Our Process - The Gnh Way

Other Pharmaceutical Products

desogestrel and ethinyl estradiol (EMOQUETTE)

desogestrel and ethinyl estradiol (EMOQUETTE)

Liposomal Amphotericin - B for Injection IP (AmBisome)

Liposomal Amphotericin - B for Injection IP (AmBisome)

Beclomethasone Dipropionate and Levosalbutamol Inhaler (Aerocort)

Beclomethasone Dipropionate and Levosalbutamol Inhaler (Aerocort)

Monobenzone Cream USP 20% (Albaquin)

Monobenzone Cream USP 20% (Albaquin)

Melphalan Injection IP 50mg (Alkacel)

Melphalan Injection IP 50mg (Alkacel)

Edatate Calcium Disodium Injection USP 200mg/ml (Cal-Rsodate)

Edatate Calcium Disodium Injection USP 200mg/ml (Cal-Rsodate)

Are you an existing customer or a vendor of GNH India? Log in here to