Doxazosin Mesylate (Doxazosin)

Trade Name : Doxazosin

Teva Pharmaceuticals USA, Inc.

TABLET

Strength 8 mg/1

DOXAZOSIN MESYLATE Adrenergic alpha-Antagonists [MoA],alpha-Adrenergic Blocker [EPC]

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Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Doxazosin Mesylate (Doxazosin) which is also known as Doxazosin and Manufactured by Teva Pharmaceuticals USA, Inc.. It is available in strength of 8 mg/1 per ml. Read more

Doxazosin Mesylate (Doxazosin) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials.  Click to know price.     Read less

Packaging and Delivery

Validated Cold Chain Shipment

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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About GNH

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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  • Doxazosin tablets are an alpha adrenergic antagonist indicated for:
  • Signs and symptoms of Benign Prostatic Hyperplasia (BPH)
  • Treatment of Hypertension
  • No data
  • For the treatment of BPH: Initiate therapy at 1 mg once daily. Dose may be titrated at 1 to 2 week intervals, up to 8 mg once daily. ()
  • For the treatment of hypertension: Initiate therapy at 1 mg once daily. Dose may be titrated as needed, up to 16 mg once daily. ()
  • Tablets (scored): 1 mg, 2 mg, 4 mg, or 8 mg (white to off-white).
  • Tablets: 1 mg, 2 mg, 4 mg, 8 mg.
  • The use of doxazosin mesylate is contraindicated in patients with a hypersensitivity to doxazosin, other quinazolines (e.g., prazosin, terazosin), or any of its components.
  • Hypersensitivity to doxazosin, other quinazolines, or any other ingredient in doxazosin mesylate. ()
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  • Postural hypotension with or without syncope may occur. ()
  • Risk of Intraoperative Floppy Iris Syndrome during cataract surgery. ()
  • Screen for the presence of prostate cancer prior to treatment for BPH and at regular intervals afterwards. ()
  • The most commonly reported adverse reactions from clinical trials are fatigue, malaise, hypotension, and dizziness. ()
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  • Strong cytochrome P450 (CYP) 3A inhibitors may increase exposure to doxazosin and increased risk of hypotension ()
  • Concomitant administration of doxazosin mesylate with a phosphodiesterase-5 (PDE-5) inhibitor can result in additive blood pressure lowering effects and symptomatic hypotension. ()
  • No data
  • Hepatic Impairment: Monitor for hypotension. (, )
  • Experience with doxazosin mesylate overdosage is limited. Two adolescents, who each intentionally ingested 40 mg doxazosin mesylate with diclofenac or acetaminophen, were treated with gastric lavage with activated charcoal and made full recoveries. A two-year-old child who accidently ingested 4 mg doxazosin mesylate was treated with gastric lavage and remained normotensive during the five-hour emergency room observation period. A six-month-old child accidentally received a crushed 1 mg tablet of doxazosin mesylate and was reported to have been drowsy. A 32-year-old female with chronic renal failure, epilepsy, and depression intentionally ingested 60 mg doxazosin mesylate (blood level = 0.9 mcg/mL; normal values in hypertensives = 0.02 mcg/mL); death was attributed to a grand mal seizure resulting from hypotension. A 39-year-old female who ingested 70 mg doxazosin mesylate, alcohol, and Dalmane (flurazepam) developed hypotension which responded to fluid therapy.
  • The oral LD of doxazosin is greater than 1000 mg/kg in mice and rats. The most likely manifestation of overdosage would be hypotension, for which the usual treatment would be intravenous infusion of fluid. As doxazosin is highly protein bound, dialysis would not be indicated.
  • Doxazosin mesylate, USP is a quinazoline compound that is a selective inhibitor of the alpha subtype of alpha-adrenergic receptors. The chemical name of doxazosin mesylate, USP is 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl) piperazine methanesulfonate. It has the following structure:
  • CHNOu2022CHOS M.W. 547.58
  • Doxazosin mesylate, USP is freely soluble in dimethylsulfoxide, soluble in dimethylformamide, slightly soluble in methanol, ethanol, and water (0.8% at 25u00b0C), and very slightly soluble in acetone and methylene chloride. Each Doxazosin Tablet USP, for oral administration, contains 1 mg, 2 mg, 4 mg, or 8 mg of doxazosin as the free base.
  • The inactive ingredients for all tablets are: lactose monohydrate, magnesium stearate, microcrystalline cellulose, pregelatinized corn starch, sodium lauryl sulfate, and sodium starch glycolate.
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  • Doxazosin Tablets USP are supplied as follows:
  • 1 mg (doxazosin as free base): White to off-white, scored, round, biconvex compressed tablet, engraved with 590 over bisect on one side and TV on the other side. They are available in bottles of 100 tablets (NDC 0093-2070-01).
  • 2 mg (doxazosin as free base): White to off-white, scored, capsule-shaped, biconvex compressed tablet, engraved with 593 left of bisect on one side and TV on the other side. They are available in bottles of 100 tablets (NDC 0093-2069-01).
  • 4 mg (doxazosin as free base): White to off-white, scored, modified diamond-shaped, biconvex compressed tablet, engraved with 596 over bisect on one side and TV on the other side. They are available in bottles of 100 tablets (NDC 0093-2068-01).
  • 8 mg (doxazosin as free base): White to off-white, scored, round, biconvex compressed tablet, engraved TV over bisect 598 (TV/598) on one side and 8 on the other side. They are available in bottles of 100 tablets (NDC 0093-2067-01).
  • Store at 20u00b0 to 25u00b0C (68u00b0 to 77u00b0F) [See USP Controlled Room Temperature].
  • Dispense in a well-closed container.
  • KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF CHILDREN.
  • Advise the patient to read the FDA-approved patient labeling (Patient Information).
  • Postural Hypotension
  • Advise patients of the possibility of syncopal and orthostatic symptoms, especially at the initiation of therapy, and urged to avoid driving or hazardous tasks for 24 hours after the first dose, after a dosage increase, and after interruption of therapy when treatment is resumed. Advise patients to report symptoms to their healthcare provider.
  • Priapism
  • Advise patients of the possibility of priapism and to seek immediate medical attention if symptoms occur.
  • All brand names listed are the registered trademarks of their respective owners and are not trademarks of Teva Pharmaceuticals USA.
  • Manufactured In India For:
  • Teva Pharmaceuticals USA, Inc.
  • North Wales, PA 19454
  • Rev. R 6/2016
  • This Patient Information has been approved by the U.S. Food and Drug Administrationt Rev. G 6/2016
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