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Fosaprepitant Dimeglumine (Emend)

Trade Name : EMEND

Merck Sharp & Dohme Corp.

INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION

Strength 150 mg/5mL

FOSAPREPITANT DIMEGLUMINE Neurokinin 1 Antagonists [MoA],Substance P/Neurokinin-1 Receptor Antagonist [EPC],Cytochrome P450 3A4 Inhibitors [MoA],Cytochrome P450 2C9 Inducers [MoA],Cytochrome P450 3A4 Inducers [MoA]

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Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Fosaprepitant Dimeglumine (Emend) which is also known as EMEND and Manufactured by Merck Sharp & Dohme Corp.. It is available in strength of 150 mg/5mL per ml. Read more

Fosaprepitant Dimeglumine (Emend) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials.  Click to know price.     Read less

Packaging and Delivery

Validated Cold Chain Shipment

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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About GNH

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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  • No data
  • No data
  • EMEND for injection, in combination with other antiemetic agents, is indicated in adults for the prevention of:
  • Limitations of Use
  • EMEND for injection is a substance P/neurokinin-1 (NK) receptor antagonist, indicated in adults, in combination with other antiemetic agents, for the prevention of ():
  • Limitations of Use ()
  • Dosage ()
  • Preparation ()
  • EMEND for injection: 150 mg fosaprepitant, white to off-white lyophilized powder in single-dose glass vial for reconstitution
  • EMEND for injection: 150 mg fosaprepitant, lyophilized powder in single-dose vial for reconstitution. ()
  • EMEND is contraindicated in patients:
  • Known hypersensitivity to any component of this drug. (, )
  • Concurrent use with pimozide. ()
  • No data
  • CYP3A4 Interactions:
  • Hypersensitivity Reactions (including anaphylaxis and anaphylactic shock):
  • Infusion Site Reactions (including thrombophlebitis, necrosis, and vasculitis):
  • Warfarin (a CYP2C9 substrate):
  • Hormonal Contraceptives:
  • Most common adverse reactions (u22652%) are: fatigue, diarrhea, neutropenia, asthenia, anemia, peripheral neuropathy, leukopenia, dyspepsia, urinary tract infection, pain in extremity. ()n n n
  • See Full Prescribing Information for a list of clinically significant drug interactions. (, , , , , )
  • No data
  • There is no specific information on the treatment of overdosage with fosaprepitant or aprepitant.
  • In the event of overdose, EMEND should be discontinued and general supportive treatment and monitoring should be provided. Because of the antiemetic activity of EMEND, drug-induced emesis may not be effective in cases of EMEND overdosage.
  • Aprepitant is not removed by hemodialysis.
  • EMEND (fosaprepitant) for injection is a sterile, lyophilized formulation containing fosaprepitant dimeglumine, a prodrug of aprepitant, a substance P/neurokinin-1 (NK) receptor antagonist, an antiemetic agent, chemically described as 1-Deoxy-1-(methylamino)-D-glucitol[3-[[(2,3)-2-[(1)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1-1,2,4-triazol-1-yl]phosphonate (2:1) (salt).
  • Its empirical formula is CHFNOP u2219 2(CHNO) and its structural formula is:
  • Fosaprepitant dimeglumine is a white to off-white amorphous powder with a molecular weight of 1004.83. It is freely soluble in water.
  • Each vial of EMEND for injection for administration as an intravenous infusion contains 150 mg of fosaprepitant (equivalent to 245.3 mg of fosaprepitant dimeglumine) and the following inactive ingredients: edetate disodium (18.8 mg), polysorbate 80 (75 mg), lactose anhydrous (375 mg), sodium hydroxide and/or hydrochloric acid (for pH adjustment).
  • No data
  • No data
  • No data
  • No. 3941 u2014 Single-dose glass vial containing 150 mg of fosaprepitant as a white to off-white lyophilized powder for reconstitution. Supplied as follows:
  • Storage
  • Emend for injection vials must be refrigerated, store at 2u00b0C-8u00b0C (36u00b0F-46u00b0F).
  • The reconstituted final drug solution is stable for 24 hours at ambient room temperature [at or below 25u00b0C (77u00b0F)].
  • Advise the patient to read the FDA-approved patient labeling (Patient Information).
  • Manufactured for:Merck Sharp & Dohme Corp., a subsidiary of Whitehouse Station, NJ 08889, USA
  • Manufactured by:Patheon Manufacturing Services LLC, 5900 Martin Luther King Jr. Highway, Greenville, NC 27834, USA
  • For patent information: www.merck.com/product/patent/home.html
  • Copyright u00a9 2008-2018 Merck Sharp & Dohme Corp., a subsidiary of n All rights reserved.
  • uspi-mk0517-iv-edta18-1803r016
  • No data
  • NDC 0006-3884-32
  • Emendn (fosaprepitant dimeglumine)for Injection
  • 115 mg
  • Each vial contains 188 mg of fosaprepitant dimeglumine equivalent to 115 mg of fosaprepitant for infusion when reconstituted with 5 mL saline and diluted according to package insert.
  • STERILE LYOPHILIZED POWDER FOR INTRAVENOUS USE ONLY AFTER RECONSTITUTION AND DILUTION
  • DO NOT USE WITH SOLUTIONS CONTAINING DIVALENT CATIONS (e.g., Ca, Mg) INCLUDING LACTATED RINGER'S SOLUTION.
  • Rx only
  • One Single-Dose 115 mg Vial
  • NDC
  • Emendn (fosaprepitant dimeglumine)for Injection
  • 150 mg per vial
  • Each vial contains 245.3 mg of fosaprepitantdimeglumine equivalent to 150 mg offosaprepitant for infusion when reconstitutedwith 5 mL 0.9% Sodium Chloride for Injectionand diluted according to package insert.
  • STERILE LYOPHILIZED POWDERFOR INTRAVENOUS USE ONLY AFTERRECONSTITUTION AND DILUTION
  • DO NOT USE WITH SOLUTIONSCONTAINING DIVALENT CATIONS(e.g., Ca, Mg) INCLUDINGLACTATED RINGER'S SOLUTIONAND HARTMANN'S SOLUTION.
  • Rx only
  • Single-Dose Vial u2013Discard Unused Portion

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