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Hydrochlorothiazide (Hydrochlorothiazide)

Trade Name : Hydrochlorothiazide

Actavis Pharma, Inc.

TABLET

Strength 12.5 mg/1

HYDROCHLOROTHIAZIDE Increased Diuresis [PE],Thiazide Diuretic [EPC],Thiazides [CS]

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Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Hydrochlorothiazide (Hydrochlorothiazide) which is also known as Hydrochlorothiazide and Manufactured by Actavis Pharma, Inc.. It is available in strength of 12.5 mg/1 per ml. Read more

Hydrochlorothiazide (Hydrochlorothiazide) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials.  Click to know price.     Read less

Packaging and Delivery

Validated Cold Chain Shipment

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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  • No data
  • 40-9176
  • Revised u2014 November 2015
  • Rx only
  • Hydrochlorothiazide, USPu00a0is a diuretic and antihypertensive. It is the 3,4-dihydro derivative of chlorothiazide. It is chemically designated as 6-chloro-3,4-dihydro-2-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide and has the following structural formula:
  • CHClNOSu00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0 M.W. 297.74
  • Hydrochlorothiazide, USPu00a0is a white, or practically white, crystalline powder, which is slightly soluble in water, but freely soluble in sodium hydroxide solution. Each tablet for oral administration contains 12.5 mg of hydrochlorothiazide. In addition, each tablet contains the following inactive ingredients: calcium stearate, corn starch, FD&C yellow #6 (sunset yellow), lactose monohydrate, pregelatinized starch, sodium lauryl sulfate, and stearic acid.
  • The mechanism of the antihypertensive effect of thiazides is unknown. Hydrochlorothiazide does not usually affect normal blood pressure.
  • Hydrochlorothiazide affects the distal renal tubular mechanism of electrolyte reabsorption. At maximal therapeutic dosage all thiazides are approximately equal in their diuretic efficacy.
  • Hydrochlorothiazide increases excretion of sodium and chloride in approximately equivalent amounts. Natriuresis may be accompanied by some loss of potassium and bicarbonate.
  • After oral use diuresis begins within 2 hours, peaks in about 4 hours and lasts about 6 to 12 hours.
  • Anuria.
  • Hypersensitivity to this product or to other sulfonamide-derived drugs.
  • Use with caution in severe renal disease. In patients with renal disease, thiazides may precipitate azotemia. Cumulative effects of the drug may develop in patients with impaired renal function.
  • Thiazides should be used with caution in patients with impaired hepatic function or progressive liver disease, since minor alterations of fluid and electrolyte balance may precipitate hepatic coma.
  • Thiazides may add to or potentiate the action of other antihypertensive drugs.
  • Sensitivity reactions may occur in patients with or without a history of allergy or bronchial asthma.
  • The possibility of exacerbation or activation of systemic lupus erythematosus has been reported.
  • Lithium generally should not be given with diuretics (see ).
  • No data
  • The following adverse reactions have been reported and, within each category, are listed in order of decreasing severity.
  • Body As A Whole:
  • Cardiovascular:
  • Digestive:
  • Hematologic:
  • Hypersensitivity:
  • Metabolic: n- PRECAUTIONS
  • Musculoskeletal:
  • Nervous System/Psychiatric:
  • Renal: n- WARNINGS
  • Skin:
  • Special Senses:
  • Urogenital:
  • Whenever adverse reactions are moderate or severe, thiazide dosage should be reduced or therapy withdrawn.
  • To report SUSPECTED ADVERSE EVENTS, contact Actavis at 1-800-432-8534 or FDA at 1-800-FDA-1088 or http://www.fda.gov/ for voluntary reporting of adverse reactions.
  • The most common signs and symptoms observed are those caused by electrolyte depletion (hypokalemia, hypochloremia, hyponatremia) and dehydration resulting from excessive diuresis. If digitalis has also been administered, hypokalemia may accentuate cardiac arrhythmias.
  • In the event of overdosage, symptomatic and supportive measures should be employed. Emesis should be induced or gastric lavage performed. Correct dehydration, electrolyte imbalance, hepatic coma and hypotension by established procedures. If required, give oxygen or artificial respiration for respiratory impairment. The degree to which hydrochlorothiazide is removed by hemodialysis has not been established.
  • The oral LD of hydrochlorothiazide is greater than 10 g/kg in the mouse and rat.
  • Therapy should be individualized according to patient response. Use the smallest dosage necessary to achieve the required response.
  • Hydrochlorothiazide Tablets, USP are available as follows:
  • 12.5 mg u2014 Each peach, round, tablet imprinted with on one side and 20 on the other side contains 12.5 mg of Hydrochlorothiazide, USP and is supplied in bottles of 100 (NDC 0228-2820-11).
  • Dispense in a well-closed container as defined in the USP.
  • Keep container tightly closed.u00a0 Protect from light, moisture, and freezing, -20u00b0C (-4u00b0F).
  • Store at 20-25u00b0C (68-77u00b0F) [See USP Controlled Room Temperature].
  • Manufactured by:Actavis Elizabeth LLCElizabeth, NJ 07207 USA
  • Distributed by:Actavis Pharma, Inc.Parsippany, NJ 07054 USA
  • 40-9176
  • Revised u2014 November 2015
  • NDC 0228--11
  • 12.5 mg
  • Hydrochlorothiazide Tablets, USP
  • 100 Tablets
  • Rx Only
  • Actavis

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