Latrodectus Mactans (Antivenin)

Trade Name : ANTIVENIN

Merck Sharp & Dohme Corp.

KIT, PLASMA DERIVATIVE

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GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Latrodectus Mactans (Antivenin) which is also known as ANTIVENIN and Manufactured by Merck Sharp & Dohme Corp.. It is available in strength of per ml. Read more

Latrodectus Mactans (Antivenin) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials. Click to know price. Read less

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Antivenin () is a sterile, non-pyrogenic preparation derived by drying a frozen solution of specific venom-neutralizing globulins obtained from the blood serum of healthy horses immunized against venom of black widow spiders (). It is standardized by biological assay on mice, in terms of one dose of Antivenin neutralizing the venom in not less than 6000 mouse LD of . Thimerosal (mercury derivative) 1:10,000 is added as a preservative. When constituted as specified, it is opalescent, ranging in color from light (straw) to very dark (iced tea), and contains not more than 20.0 percent of solids.
Each single-dose vial contains not less than 6000 Antivenin units. One unit of Antivenin will neutralize one average mouse lethal dose of black widow spider venom when the Antivenin and the venom are injected simultaneously in mice under suitable conditions.

The pharmacological mode of action is unknown and metabolic and pharmacokinetic data in humans are unavailable.

Antivenin () is used to treat patients with symptoms due to bites by the black widow spider (). Early use of the Antivenin is emphasized for prompt relief.
Local muscular cramps begin from 15 minutes to several hours after the bite which usually produces a sharp pain similar to that caused by puncture with a needle. The exact sequence of symptoms depends somewhat on the location of the bite. The venom acts on the myoneural junctions or on the nerve endings, causing an ascending motor paralysis or destruction of the peripheral nerve endings. The groups of muscles most frequently affected at first are those of the thigh, shoulder, and back. After a varying length of time, the pain becomes more severe, spreading to the abdomen, and weakness and tremor usually develop. The abdominal muscles assume a boardlike rigidity, but tenderness is slight. Respiration is thoracic. The patient is restless and anxious. Feeble pulse, cold, clammy skin, labored breathing and speech, light stupor, and delirium may occur. Convulsions also may occur, particularly in small children. The temperature may be normal or slightly elevated. Urinary retention, shock, cyanosis, nausea and vomiting, insomnia, and cold sweats also have been reported. The syndrome following the bite of the black widow spider may be confused easily with any medical or surgical condition with acute abdominal symptoms.
The symptoms of black widow spider bite increase in severity for several hours, perhaps a day, and then very slowly become less severe, gradually passing off in the course of two or three days except in fatal cases. Residual symptoms such as general weakness, tingling, nervousness, and transient muscle spasm may persist for weeks or months after recovery from the acute stage.
If possible, the patient should be hospitalized. Other additional measures giving greatest relief are prolonged warm baths and intravenous injection of 10u00a0mL of 10 percent solution of calcium gluconate repeated as necessary to control muscle pain. Morphine also may be required to control pain. Barbiturates may be used for extreme restlessness. However, as the venom is a neurotoxin, it can cause respiratory paralysis. This must be borne in mind when considering use of morphine or a barbiturate. Adrenocorticosteroids have been used with varying degrees of success. Supportive therapy is indicated by the condition of the patient. Local treatment of the site of the bite is of no value. Nothing is gained by applying a tourniquet or by attempting to remove venom from the site of the bite by incision and suction.
In otherwise healthy individuals between the ages of 16 and 60, the use of Antivenin may be deferred and treatment with muscle relaxants may be considered.

Prior to treatment with any product prepared from horse serum, a careful review of the patient's history should be taken emphasizing prior exposure to horse serum or any allergies. Serum sickness and even death could result from the use of horse serum in a sensitive patient. A skin or conjunctival test should be performed prior to administration of Antivenin. However, an anaphylactic reaction to Antivenin may occur even following a negative skin or conjunctival test (see ).
Skin test:
Conjunctival test:
Patients should be observed for serum sickness for an average of 8 to 12 days following administration of Antivenin.
Desensitization should be attempted only when the administration of Antivenin is considered necessary to save life. Epinephrine must be available in case of untoward reaction.
Desensitization:

No data

The following adverse reactions have been reported following the use of Antivenin: Hypersensitivity reactions including anaphylaxis and serum sickness. Muscle cramps have also been reported.

Using a sterile syringe, inject 2.5 mL of Sterile Water for Injection into the single-dose vial of Antivenin. With the needle still in the rubber stopper, shake the vial to dissolve the contents completely.
Parenteral drug products should be inspected visually for particulate matter prior to administration, whenever solution and container permit (see ).
The dose for adults and children is the entire contents of a restored single-dose vial (2.5u00a0mL) of Antivenin. It may be given intramuscularly, preferably in the region of the anterolateral thigh so that a tourniquet may be applied in the event of a systemic reaction. Symptoms usually subside in 1 to 3 hours. Although one dose of Antivenin usually is adequate, a second dose may be necessary in some cases. Discard unused portion.
Antivenin also may be given intravenously in 10 to 50u00a0mL of saline solution over a 15 minute period. It is the preferred route in severe cases, or when the patient is under 12, or in shock. One restored single-dose vial usually is enough. Discard unused portion.

No. 5424 u2014 Antivenin (), equine origin is a white to gray crystalline powder, each single-dose vial containing not less than 6000 Antivenin units. Thimerosal (mercury derivative) 1:10,000 is added as preservative, 0006-5424-02. A single-dose 1 mL vial of normal horse serum (1:10 dilution) for sensitivity testing is also included. Thimerosal (mercury derivative) 1:10,000 is added as preservative.
Antivenin must be stored and shipped at 2-8u00b0C (36-46u00b0F). When reconstituted as directed, the color of Antivenin ranges from light (straw) to very dark (iced tea), but the color has no effect on potency. n

Barron, W. E.: Spider Bites, J. Med. Ass. Georgia 511-512, Oct. 1960.
Micks, D. W.: Insects and Other Arthropods of Medical Importance in Texas, Tex. Rep. Biol. & Med. 624-635, Winter 1960.
Prince, G. E.: Arachnidism in Children, J. Pediat. 101-108, July 1956.
Russell, F. E.: Injuries by Venomous Animals in the United States, J. Amer. Med. Ass. 903-907, Sept. 30, 1961.
Russell, F. E.: Muscle Relaxants in Black Widow Spider () Poisoning, Amer. J. Med. Sci. 159-162, Feb. 1962.
Russell, F. E.: Venom Poisoning, Rational Drug Therap. 5-6, Aug. 1971.

Distributed by: Merck Sharp & Dohme Corp., a subsidiary of Whitehouse Station, NJ 08889, USA
For patent information: www.merck.com/product/patent/home.html
Copyright u00a9 2013-2020 Merck Sharp & Dohme Corp., a subsidiary of n All rights reserved.
Revised: 02/2020
uspi-mk9001-i-2002r023

NDC 0006-5424-02
2.5 mL Vial
ANTIVENIN(LATRODECTUS MACTANS)(BLACK WIDOW SPIDER ANTIVENIN)Equine Origin
Rx only
For Intramuscular or Intravenous Use

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Latrodectus Mactans (Antivenin)

Trade Name : ANTIVENIN

KIT, PLASMA DERIVATIVE

Delivery Process

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Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

Packaging and Delivery

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Latrodectus Mactans (Antivenin)

Trade Name : ANTIVENIN

KIT, PLASMA DERIVATIVE

Delivery Process

Product information is meant for

Disclaimer

Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

Packaging and Delivery

About GNH

Similar Products

Desogestrel And Ethinyl Estradiol (Emoquette)

Diphenoxylate Hydrochloride And Atropine Sulfate (Diphenoxylate Hydrochloride And Atropine Sulfate)

Fluoxetine Hydrochloride (Fluoxetine)

Metoprolol Succinate (Metoprolol Succinate)

Losartan Potassium (Losartan Potassium)

Browse Our Services And Processes

Disclaimer

Browse from other international pharmaceuticals

General

US NDC

Canadian DIN

Swiss Drugs

NZ Drugs

FAQ

Can’t find what you’re looking for?

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CONTACT US

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