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Lisinopril (Lisinopril)

Trade Name : Lisinopril

West-Ward Pharmaceuticals Corp

TABLET

Strength 20 mg/1

LISINOPRIL Angiotensin Converting Enzyme Inhibitor [EPC],Angiotensin-converting Enzyme Inhibitors [MoA]

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Disclaimer

Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Lisinopril (Lisinopril) which is also known as Lisinopril and Manufactured by West-Ward Pharmaceuticals Corp. It is available in strength of 20 mg/1 per ml. Read more

Lisinopril (Lisinopril) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials.  Click to know price.     Read less

Packaging and Delivery

Validated Cold Chain Shipment

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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About GNH

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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  • No data
  • WARNING: FETAL TOXICITYn
  • When pregnancy is detected, discontinue lisinopril tablets as soon as possible. ()
  • Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. ()
  • Lisinopril Tablets, USP is an angiotensin-converting enzyme (ACE) inhibitor indicated for:
  • No data
  • Lisinopril Tablets, USP 2.5 mg: White, Capsule Shape Tablet, Bisected Tablet; Debossed u201cWW 65u201d
  • Lisinopril Tablets, USP 5 mg: Pink, Mottled, Capsule Shape Tablet, Bisected Tablet; Debossed u201cWW 66u201d
  • Lisinopril Tablets, USP 10 mg: Pink, Mottled, Round Tablet; Debossed u201cWWu201d on one side and u201c267u201d on the other side.
  • Lisinopril Tablets, USP 20 mg: Red, Mottled, Round Tablet; Debossed u201cWW 268u201d
  • Tablets: 2.5 mg, 5 mg, 10 mg, 20 mg ()
  • Lisinopril tablets are contraindicated in patients with:
  • Do not co-administer aliskiren with lisinopril tablets in patients with diabetes [see].
  • No data
  • Common adverse reactions (events 2% greater than placebo) by use:
  • To report SUSPECTED ADVERSE REACTIONS, contact West-Ward Pharmaceutical Corp. at 1-877-233-2001, or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
  • No data
  • No data
  • Following a single oral dose of 20u00a0g/kg no lethality occurred in rats, and death occurred in one of 20 mice receiving the same dose. The most likely manifestation of overdosage would be hypotension, for which the usual treatment would be intravenous infusion of normal saline solution.
  • Lisinopril can be removed by hemodialysis [see].
  • Lisinopril is an oral long-acting angiotensin converting enzyme (ACE) inhibitor. Lisinopril, a synthetic peptide derivative, is chemically described as (S)-1-[N2-(1-carboxy-3-phenylpropyl)-L-lysyl]-L-proline dihydrate. Its empirical formula is CHNOu20222HO and its structural formula is:
  • Lisinopril is a white to off-white, crystalline powder, with a molecular weight of 441.53. It is soluble in water and sparingly soluble in methanol and practically insoluble in ethanol.
  • Lisinopril Tablets, USP are supplied as 2.5 mg, 5 mg, 10 mg, and 20 mg tablets for oral administration.
  • Inactive ingredients:
  • 2.5 mg: Corn Starch, Colloidal Silicon Dioxide, Dibasic Calcium Phosphate, Magnesium Stearate, Mannitol, and Sodium Starch Glycolate (derived from potato).
  • 5 mg, 10 mg, and 20 mg: Corn Starch, Colloidal Silicon Dioxide, Dibasic Calcium Phosphate, Magnesium Stearate, Mannitol, Red Iron Oxide, and Sodium Starch Glycolate (derived from potato).
  • No data
  • There was no evidence of a tumorigenic effect when lisinopril was administered for 105 weeks to male and female rats at doses up to 90 mg per kg per day (about 56 or 9 times the maximum recommended daily human dose, based on body weight and body surface area, respectively). There was no evidence of carcinogenicity when lisinopril was administered for 92 weeks to (male and female) mice at doses up to 135 mg per kg per day (about 84 times* the maximum recommended daily human dose). This dose was 6.8 times the maximum human dose based on body surface area in mice.
  • Lisinopril was not mutagenic in the Ames microbial mutagen test with or without metabolic activation. It was also negative in a forward mutation assay using Chinese hamster lung cells. Lisinopril did not produce single strand DNA breaks in an alkaline elution rat hepatocyte assay. In addition, lisinopril did not produce increases in chromosomal aberrations in an test in Chinese hamster ovary cells or in an study in mouse bone marrow.
  • There were no adverse effects on reproductive performance in male and female rats treated with up to 300 mg per kg per day of lisinopril. This dose is 188 times and 30 times the maximum human dose when based on mg/kg and mg/m, respectively.
  • Studies in rats indicate that lisinopril crosses the blood brain barrier poorly. Multiple doses of lisinopril in rats do not result in accumulation in any tissues. Milk of lactating rats contains radioactivity following administration of C lisinopril. By whole body autoradiography, radioactivity was found in the placenta following administration of labeled drug to pregnant rats, but none was found in the fetuses.
  • *Calculations assume a human weight of 50 kg and human body surface area of 1.62 mn
  • No data
  • Lisinopril Tablets, USP 2.5 mg: White, Capsule Shape Tablet, Bisected Tablet; Debossed u201cWW 65u201dBottles of 100 tabletsBottles of 1000 tablets
  • Lisinopril Tablets, USP 5 mg: Pink, Mottled, Capsule Shape Tablet, Bisected Tablet; Debossed u201cWW 66u201dBottles of 100 tabletsBottles of 1000 tablets
  • Lisinopril Tablets, USP 10 mg: Pink, Mottled, Round Tablet; Debossed u201cWWu201d on one side and u201c267u201d on the other side.Bottles of 100 tabletsBottles of 1000 tablets
  • Lisinopril Tablets, USP 20 mg: Red, Mottled, Round Tablet; Debossed u201cWW 268u201dBottles of 100 tabletsBottles of 1000 tablets
  • Store at 20u00b0 to 25u00b0C (68u00b0 to 77u00b0F) [See USP Controlled Room Temperature]. Protect from moisture, freezing and excessive heat.
  • Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.
  • NOTE: This information is intended to aid in the safe and effective use of this medication. It is not a disclosure of all possible adverse or intended effects.
  • Pregnancy: Tell female patients of childbearing age about the consequences of exposure to lisinopril tablets during pregnancy. Discuss treatment options with women planning to become pregnant. Tell patients to report pregnancies to their physicians as soon as possible.
  • Angioedema: Angioedema, including laryngeal edema may occur at any time during treatment with angiotensin converting enzyme inhibitors, including lisinopril tablets. Tell patients to report immediately any signs or symptoms suggesting angioedema (swelling of face, extremities, eyes, lips, tongue, difficulty in swallowing or breathing) and to take no more drug until they have consulted with the prescribing physician.
  • Symptomatic Hypotension: Tell patients to report light-headedness especially during the first few days of therapy. If actual syncope occurs, tell the patient to discontinue the drug until they have consulted with the prescribing physician.
  • Tell patients that excessive perspiration and dehydration may lead to an excessive fall in blood pressure because of reduction in fluid volume. Other causes of volume depletion such as vomiting or diarrhea may also lead to a fall in blood pressure; advise patients accordingly.
  • Hyperkalemia: Tell patients not to use salt substitutes containing potassium without consulting their physician.
  • Hypoglycemia: Tell diabetic patients treated with oral antidiabetic agents or insulin starting an ACE inhibitor to monitor for hypoglycemia closely, especially during the first month of combined use [see].
  • Leukopenia/Neutropenia: Tell patients to report promptly any indication of infection (e.g., sore throat, fever), which may be a sign of leukopenia/neutropenia.
  • Manufactured by:n n n n
  • Distributed by:n n- West-Ward Pharmaceutical Corp.n
  • Revised January 2015
  • [West-Ward Logo]
  • Principal Display Paneln- Lisinopril Tablets, USPn- 2.5 mgn- West-Ward Pharmaceutical Corp.
  • Arrayn- Array
  • Principal Display Paneln- Lisinopril Tablets, USPn- 5 mgn- West-Ward Pharmaceuticals Corp.
  • Arrayn- Array
  • Principal Display Paneln- Lisinopril Tablets, USPn- 10 mgn- West-Ward Pharmaceuticals Corp.
  • Arrayn- Array
  • Principal Display Paneln- Lisinopril Tablets, USPn- 20 mgn- West-Ward Pharmaceuticals Corp.
  • Arrayn- Array

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Comparator Sourcing for Clinical Trials

Comparator Sourcing for Clinical Trials

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Name Patient Supply

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Today, the exact cause for many rare diseases remains unknown

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Validated Cold Chain Shipment

Validated Cold Chain Shipment

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Clinical Trials Supply

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