Losartan Potassium And Hydrochlorothiazide (Hyzaar)

Trade Name : HYZAAR

Merck Sharp & Dohme Corp.

TABLET, FILM COATED

Strength 5012.5 mg/1mg/1

LOSARTAN POTASSIUM; HYDROCHLOROTHIAZIDE Angiotensin 2 Receptor Antagonists [MoA],Angiotensin 2 Receptor Blocker [EPC],Increased Diuresis [PE],Thiazide Diuretic [EPC],Thiazides [CS]

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Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Losartan Potassium And Hydrochlorothiazide (Hyzaar) which is also known as HYZAAR and Manufactured by Merck Sharp & Dohme Corp.. It is available in strength of 50; 12.5 mg/1; mg/1 per ml. Read more

Losartan Potassium And Hydrochlorothiazide (Hyzaar) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials.  Click to know price.     Read less

Packaging and Delivery

Validated Cold Chain Shipment

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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About GNH

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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  • When pregnancy is detected, discontinue HYZAAR as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus n
  • WARNING: FETAL TOXICITY
  • See full prescribing information for complete boxed warning.
  • When pregnancy is detected, discontinue HYZAAR as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. ()
  • HYZAAR is a combination of losartan, an angiotensin II receptor blocker (ARB) and hydrochlorothiazide, a diuretic indicated for:
  • Treatment of hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. ()
  • Reduction of the risk of stroke in patients with hypertension and left ventricular hypertrophy. There is evidence that this benefit does not apply to Black patients. ()
  • Hypertension
  • Hypertensive Patients with Left Ventricular Hypertrophy
  • Tablets (losartan potassium/hydrochlorothiazide content): 50/12.5 mg; 100/12.5 mg; and 100/25 mg. ()
  • HYZAAR is contraindicated:
  • Hypersensitivity to any component of HYZAAR. ()
  • Anuria. ()
  • Coadministration with aliskiren in patients with diabetes. ()
  • No data
  • Hypotension: Correct volume or salt depletion prior to administration of HYZAAR. ()
  • Monitor renal function and potassium in susceptible patients. ()
  • Observe for clinical signs of fluid or electrolyte imbalance. ()
  • Acute angle-closure glaucoma. ()
  • Exacerbation of systemic lupus erythematosus. ()
  • Most common adverse reactions (incidence u22652% and greater than placebo) are dizziness, upper respiratory infection, cough, and back pain. ()
  • To report SUSPECTED ADVERSE REACTIONS, contact Merck Sharp & Dohme Corp., a subsidiary of Merck & Co., Inc., at 1-877-888-4231 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
  • No data
  • Agents increasing serum potassium: Risk of hyperkalemia. ()
  • Lithium: Risk of lithium toxicity. ()
  • Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): increased risk of renal impairment and reduced diuretic, natriuretic, and antihypertensive effects. ()
  • Dual inhibition of the renin-angiotensin system: increased risk of renal impairment, hypotension, syncope, and hyperkalemia. ()
  • Antidiabetic drugs: dosage adjustment of antidiabetic may be required. ()
  • Cholestyramine and colestipol: Reduced absorption of thiazides. ()
  • No data
  • Hepatic Impairment: HYZAAR is not recommended for initial therapy, because the recommended starting dose is not available. ()
  • No data
  • HYZAAR 50/12.5 (losartan potassium-hydrochlorothiazide), HYZAAR 100/12.5 (losartan potassium-hydrochlorothiazide) and HYZAAR 100/25 (losartan potassium-hydrochlorothiazide) tablets combine an angiotensin II receptor blocker acting on the AT receptor subtype and a diuretic, hydrochlorothiazide.
  • Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[(-1-tetrazol-5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt. Its empirical formula is CHClKNO, and its structural formula is:
  • Losartan potassium is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone.
  • Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.
  • Hydrochlorothiazide is 6-chloro-3,4-dihydro-2-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide. Its empirical formula is CHClNOS and its structural formula is:
  • Hydrochlorothiazide is a white, or practically white, crystalline powder with a molecular weight of 297.74, which is slightly soluble in water, but freely soluble in sodium hydroxide solution.
  • HYZAAR is available for oral administration in three tablet combinations of losartan and hydrochlorothiazide. HYZAAR 50/12.5 contains 50 mg of losartan potassium and 12.5 mg of hydrochlorothiazide. HYZAAR 100/12.5 contains 100 mg of losartan potassium and 12.5 mg of hydrochlorothiazide. HYZAAR 100/25 contains 100 mg of losartan potassium and 25 mg of hydrochlorothiazide. Inactive ingredients are microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide. HYZAAR 50/12.5 and HYZAAR 100/25 also contain D&C yellow No. 10 aluminum lake. HYZAAR 50/12.5, HYZAAR 100/12.5, and HYZAAR 100/25 may also contain carnauba wax.
  • HYZAAR 50/12.5 contains 4.24 mg (0.108 mEq) of potassium, HYZAAR 100/12.5 contains 8.48 mg (0.216 mEq) of potassium, and HYZAAR 100/25 contains 8.48 mg (0.216 mEq) of potassium.
  • No data
  • No data
  • No data
  • HYZAAR is supplied as a film-coated tablet.
  • Store at 25u00b0C (77u00b0F); excursions permitted to 15-30u00b0C (59-86u00b0F) [see USP Controlled Room Temperature]. Keep container tightly closed. Protect from light.
  • Advise the patient to read the FDA-approved patient labeling (Patient Information).
  • Manufactured for: Merck Sharp & Dohme Corp., a subsidiary ofn Whitehouse Station, NJ 08889, USA
  • For patent information: www.merck.com/product/patent/home.html
  • Copyright u00a9 1995-2019 Merck Sharp & Dohme Corp., a subsidiary of n All rights reserved.
  • uspi-mk0954a-t-1911r012
  • Patient InformationHYZAARn (HY-zar) (losartan potassium and hydrochlorothiazide tablets)50/12.5 mg, 100/12.5 mg, 100/25 mgRx only
  • Read the Patient Information that comes with HYZAAR before you start taking it and each time you get a refill. There may be new information. This leaflet does not take the place of talking with your doctor about your condition and treatment.
  • What is the most important information I should know about HYZAAR?
  • What is HYZAAR?
  • HYZAAR contains 2 prescription medicines, an angiotensin receptor blocker (ARB) and a diuretic (water pill). It is used to:
  • HYZAAR has not been studied in children less than 18 years old.
  • High Blood Pressure (hypertension).
  • Left Ventricular Hypertrophy (LVH)
  • Who should not take HYZAAR?
  • Do not take HYZAAR if you:
  • What should I tell my doctor before taking HYZAAR?
  • Tell your doctor about all your medical conditions including if you:
  • Tell your doctor about all of the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.
  • HYZAAR and certain other medicines may interact with each other. Especially tell your doctor if you are taking:
  • Know the medicines you take. Keep a list of your medicines and show it to your doctor and pharmacist when you get a new medicine.
  • How should I take HYZAAR?
  • What are the possible side effects of HYZAAR?
  • HYZAAR may cause the following side effects that may be serious:
  • The most common side effects of HYZAAR in people with high blood pressure are:
  • Tell your doctor if you get any side effect that bothers you or that won't go away. This is a complete list of side effects. For a complete list, ask your doctor or pharmacist.
  • How should I store HYZAAR?
  • General information about HYZAAR
  • Medicines are sometimes prescribed for conditions that are not mentioned in patient information leaflets. Do not use HYZAAR for a condition for which it was not prescribed. Do not give HYZAAR to other people, even if they have the same symptoms that you have. It may harm them.
  • This leaflet summarizes the most important information about HYZAAR. If you would like more information, talk with your doctor. You can ask your pharmacist or doctor for information that is written for health professionals.
  • What are the ingredients in HYZAAR?
  • Active ingredients:
  • Inactive ingredients:
  • microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, titanium dioxide. HYZAAR 50/12.5 and HYZAAR 100/25 also contain D&C yellow No. 10 aluminum lake.
  • HYZAAR 50/12.5, HYZAAR 100/12.5, and HYZAAR 100/25 may also contain carnauba wax.
  • Manufactured for: Merck Sharp & Dohme Corp., a subsidiary ofn Whitehouse Station, NJ 08889, USA
  • For patent information: www.merck.com/product/patent/home.html
  • Copyright u00a9 2006-2018 Merck Sharp & Dohme Corp., a subsidiary of n All rights reserved.
  • Revised: 10/2018
  • usppi-mk0954a-t-1810r010
  • NDC 0006-0717-31
  • Hyzaarn (Losartan Potassium andHydrochlorothiazide Tablets)
  • 50 mg/12.5 mg
  • Each tablet contains 50 mg losartan potassium and12.5 mg hydrochlorothiazide.Store at 25u00b0C (77u00b0F); excursions permitted to 15-30u00b0C (59-86u00b0F) [see USP Controlled Room Temperature]. Keep container tightly closed. Protect from light.
  • Rx only
  • 30 Tablets
  • NDC 0006-0745-31
  • Hyzaarn (Losartan Potassium andHydrochlorothiazide Tablets)
  • 100 mg/12.5 mg
  • Each tablet contains 100 mg losartan potassium and12.5 mg hydrochlorothiazide.Store at 25u00b0C (77u00b0F); excursions permitted to 15-30u00b0C (59-86u00b0F) [see USP Controlled Room Temperature]. Keep container tightly closed. Protect from light.
  • Rx only
  • 30 Tablets
  • NDC 0006-0747-31
  • Hyzaarn (Losartan Potassium andHydrochlorothiazide Tablets)
  • 100 mg/25 mg
  • Each tablet contains 100 mg losartan potassium and25 mg hydrochlorothiazide.Store at 25u00b0C (77u00b0F); excursions permitted to 15-30u00b0C (59-86u00b0F) [see USP Controlled Room Temperature]. Keep container tightly closed. Protect from light.
  • Rx only
  • 30 Tablets

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