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Mercaptopurine (Mercaptopurine)

Trade Name : Mercaptopurine

West-Ward Pharmaceuticals Corp.

TABLET

Strength 50 mg/1

MERCAPTOPURINE Nucleic Acid Synthesis Inhibitors [MoA],Nucleoside Metabolic Inhibitor [EPC]

Delivery Process

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Product information is meant for

Wholesalers Suppliers Exporters Doctors MOH Tender Supplies Hospitals Brand CROs Comparator Supplies Generic Cooperate Sourcing Individual Patients Indian Institutional Buyers

Disclaimer

Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Mercaptopurine (Mercaptopurine) which is also known as Mercaptopurine and Manufactured by West-Ward Pharmaceuticals Corp.. It is available in strength of 50 mg/1 per ml. Read more

Mercaptopurine (Mercaptopurine) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials.  Click to know price.     Read less

Packaging and Delivery

Validated Cold Chain Shipment

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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About GNH

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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  • No data
  • CAUTION
  • Mercaptopurine is a potent drug. It should not be used unless a diagnosis of acute lymphatic leukemia has been adequately established and the responsible physician is experienced with the risks of mercaptopurine and knowledgeable in assessing response to chemotherapy.
  • Mercaptopurine was synthesized and developed by Hitchings, Elion, and associates at the Wellcome Research Laboratories.
  • Mercaptopurine USP, known chemically as 6H-Purine-6-thione, 1,7-dihydro-monohydrate, is an analogue of the purine bases adenine and hypoxanthine. Its structural formula is:
  • Mercaptopurine Tablets USP are available in tablet form for oral administration. Each scored tablet contains 50 mg mercaptopurine and the following inactive ingredients: corn starch, hypromellose, lactose (anhydrous), lactose monohydrate, magnesium stearate, potato starch, sodium starch glycolate and stearic acid.
  • Each tablet meets the requirements of Test 2 for Dissolution in the USP monograph for Mercaptopurine Tablets USP.
  • No data
  • Mercaptopurine tablets are indicated for maintenance therapy of acute lymphatic (lymphocytic, lymophoblastic) leukemia as part of a combination regimen. The response to this agent depends upon the particular subclassification of acute lymphatic leukemia and the age of the patient (pediatric or adult).
  • Mercaptopurine tablets are not effective prophylaxis or treatment of central nervous system leukemia.
  • Mercaptopurine tablets are not effective in acute myelogenous leukemia, chronic lymphatic leukemia, the lymphomas (including Hodgkins Disease), or solid tumors.
  • Mercaptopurine tablets should not be used in patients whose disease has demonstrated prior resistance to this drug. In animals and humans, there is usually complete cross-resistance between mercaptopurine and thioguanine.
  • Mercaptopurine tablets should not be used in patients who have a hypersensitivity to mercaptopurine or any component of the formulation.
  • Mercaptopurine is mutagenic in animals and humans, carcinogenic in animals, and may increase the patient's risk of neoplasia. Cases of hepatosplenic T-cell lymphoma have been reported in patients treated with mercaptopurine for inflammatory bowel disease. The safety and efficacy of mercaptopurine in patients with inflammatory bowel disease have not been established.
  • No data
  • The principal and potentially serious toxic effects of mercaptopurine are bone marrow toxicity and hepatotoxicity (see and ).
  • Signs and symptoms of overdosage may be immediate (anorexia, nausea, vomiting, and diarrhea); or delayed (myelosuppression, liver dysfunction, and gastroenteritis). Dialysis cannot be expected to clear mercaptopurine. Hemodialysis is thought to be of marginal use due to the rapid intracellular incorporation of mercaptopurine into active metabolites with long persistence. The oral LD of mercaptopurine was determined to be 480 mg/kg in the mouse and 425 mg/kg in the rat.
  • There is no known pharmacologic antagonist of mercaptopurine. The drug should be discontinued immediately if unintended toxicity occurs during treatment. If a patient is seen immediately following an accidental overdosage of the drug, it may be useful to induce emesis.
  • No data
  • Mercaptopurine Tablets USP
  • 50 mg supplied as pale yellow, biconvex tablets, with product identification u201c54 420u201d on one side and a score on the other side.
  • NDC 0054-4581-11: Bottle of 25 Tablets
  • NDC 0054-4581-27: Bottle of 250 Tablets
  • Store at 20u00b0 to 25u00b0C (68u00b0 to 77u00b0F). [See USP Controlled Room Temperature.] Store in a dry place. Dispense in a tight, child-resistant container as defined in the USP/NF.
  • Distr. by:n
  • Pharmaceuticals Corp.
  • Eatontown, NJ 07724
  • 10002106/08
  • Revised November 2018
  • Mercaptopurine Tablets USP
  • NDC 0054-4581-11: Bottle of 25 tablets
  • Rx only
  • Mercaptopurine Tablets USP
  • NDC 0054-4581-27: Bottle of 250 tablets
  • Rx only

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