Trade Name: Methocarbamol

Following information is meant for : Wholesalers, Suppliers, Exporters, Doctors, CROs, Comparator Supplies, Hospitals, MOH Tender Supplies, Generic, Brand, Cooperate Sourcing, India, Institutional Buyers.

Manufacturer: NuCare Pharmaceuticals, Inc.

Presentation: TABLET, HUMAN PRESCRIPTION DRUG

Strength: 750 mg/1

Storage and handling

METHOCARBAMOL Centrally-mediated Muscle Relaxation [PE],Muscle Relaxant [EPC]

Disclaimer:
  1. These products are NOT FOR SALE in US territories. We offer them for Exports outside of US Territories to Trade Professionals or patients with a valid prescription.
  2. Trademark shown are property of their respective owners and GNH India does not lay any claim on them.
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  • Methocarbamol tablets USP a carbamate derivative of guaifenesin, is a central nervous system (CNS) depressant with sedative and musculoskeletal relaxant properties.n n nThe chemical name of methocarbamol is 3-(2-methoxyphenoxy)-1,2-propanediol 1-carbamate and has the empirical formula C n H n NO n . Its molecular weight is 241.24. The structural formula is shown below. n n n n n n n nMethocarbamol is a white powder, sparingly soluble in water and chloroform, soluble in alcohol (only with heating) and propylene glycol, and insoluble in benzene and n-hexane.n n nMethocarbamol tablets USP are available as 500 mg and 750 mg tablets for oral administration. Methocarbamol tablets USP 500 mg and 750 mg contain the following inactive ingredients: sodium lauryl sulfate, sodium starch glycolate, povidone K 90, polyethylene glycol, magnesium stearate, colloidal silicon dioxide, low substituted hydroxypropyl cellulose and stearic acid.n
  • The mechanism of action of methocarbamol in humans has not been established, but may be due to general central nervous system (CNS) depression. It has no direct action on the contractile mechanism of striated muscle, the motor end plate or the nerve fiber.
  • Methocarbamol tablets USP are indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions. The mode of action of methocarbamol has not been clearly identified, but may be related to its sedative properties. Methocarbamol does not directly relax tense skeletal muscles in man.
  • Methocarbamol tablets USP are contraindicated in patients hypersensitive to methocarbamol or to any of the tablet components.
  • Since methocarbamol may possess a general CNS depressant effect, patients receiving methocarbamol tablets USP should be cautioned about combined effects with alcohol and other CNS depressants.n n nSafe use of methocarbamol tablets USP has not been established with regard to possible adverse effects upon fetal development. There have been reports of fetal and congenital abnormalities following in utero exposure to methocarbamol. Therefore, methocarbamol tablets USP should not be used in women who are or may become pregnant and particularly during early pregnancy unless in the judgment of the physician the potential benefits outweigh the possible hazardsn
  • (see n , n ). n
  • Methocarbamol may impair mental and/or physical abilities required for performance of hazardous tasks, such as operating machinery or driving a motor vehicle. Patients should be cautioned about operating machinery, including automobiles, until they are reasonably certain that methocarbamol therapy does not adversely affect their ability to engage in such activities.
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  • Adverse reactions reported coincident with the administration of methocarbamol include:
  • Body as a whole
  • : Anaphylactic reaction, angioneurotic edema, fever, headache
  • Cardiovascular system
  • : Bradycardia, flushing, hypotension, syncope, thrombophlebitis
  • Digestive system:
  • Dyspepsia, jaundice (including cholestatic jaundice), nausea and vomiting
  • Hemic and lymphatic system:
  • Leukopenia
  • Immune system
  • : Hypersensitivity reactions
  • Nervous system:
  • Amnesia, confusion, diplopia, dizziness or lightheadedness, drowsiness, insomnia, mild muscular incoordination, nystagmus, sedation, seizures (including grand mal), vertigo
  • Skin and special senses
  • : Blurred vision, conjunctivitis, nasal congestion, metallic taste, pruritus, rash, urticarial
  • Limited information is available on the acute toxicity of methocarbamol. Overdose of methocarbamol is frequently in conjunction with alcohol or other CNS depressants and includes the following symptoms: nausea, drowsiness, blurred vision, hypotension, seizures, and coma.n n nIn post-marketing experience, deaths have been reported with an overdose of methocarbamol alone or in the presence of other CNS depressants, alcohol or psychotropic drugs.n
  • Management of overdose includes symptomatic and supportive treatment. Supportive measures include maintenance of an adequate airway, monitoring urinary output and vital signs, and administration of intravenous fluids if necessary. The usefulness of hemodialysis in managing overdose is unknown.
  • Methocarbamol Tablets USP 500 mg u2013 Adults:n n nInitial dosage: 3 tablets q.i.d.n n nMaintenance dosage: 2 tablets q.i.d.n n nMethocarbamol Tablets USP 750 mg u2013 Adults:n n nInitial dosage: 2 tablets q.i.d.n n nMaintenance dosage: 1 tablet q.4h. or 2 tablets t.i.d.n n nSix grams a day are recommended for the first 48 to 72 hours of treatment. (For severe conditions 8 grams a day may be administered). Thereafter, the dosage can usually be reduced to approximately 4 grams a day.n
  • Methocarbamol tablets USP 750 mg are white to off white, capsule shaped, tablets debossed with u2018Hu2019 on one side and u2018115u2019 on other side . They are supplied as follows:n nBottles of 12 NDC 66267-146-12n
  • Bottles of 20 NDC 66267-146-20
  • Bottles of 30 NDC 66267-146-30
  • Bottles of 40 NDC 66267-146-40
  • Bottles of 60 NDC 66267-146-60
  • Bottles of 90 NDC 66267-146-90
  • Store at 20u00b0 to 25u00b0C (68u00b0 to 77u00b0F) [see USP Controlled Room Temperature].
  • Dispense in tight container.
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GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler, Supplier, Exporters from India of Methocarbamol (Methocarbamol) which is also known as Methocarbamol and Manufactured by NuCare Pharmaceuticals, Inc.. It is available in strength of 750 mg/1.

Methocarbamol (Methocarbamol) is supplied for Tenders, Emergency imports, Un - licensed, Specials, Orphan drug, Name patient line, RLD supplies, Reference listed drugs, Comparator Drug, Bio-Similar, Innovator samples, For Clinical trials. Click to know price.

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