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Polymyxin B Sulfate And Trimethoprim Sulfate (Polytrim)

Trade Name : Polytrim

Allergan, Inc.

SOLUTION/ DROPS

Strength 1000001 [USP'U]/mLmg/mL

POLYMYXIN B SULFATE; TRIMETHOPRIM SULFATE Polymyxin-class Antibacterial [EPC],Polymyxins [CS],Dihydrofolate Reductase Inhibitor Antibacterial [EPC],Dihydrofolate Reductase Inhibitors [MoA],Cytochrome P450 2C8 Inhibitors [MoA],Organic Cation Transporter 2 Inhibitors [MoA]

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Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Polymyxin B Sulfate And Trimethoprim Sulfate (Polytrim) which is also known as Polytrim and Manufactured by Allergan, Inc.. It is available in strength of 100000; 1 [USP'U]/mL; mg/mL per ml. Read more

Polymyxin B Sulfate And Trimethoprim Sulfate (Polytrim) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials.  Click to know price.     Read less

Packaging and Delivery

Validated Cold Chain Shipment

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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About GNH

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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  • No data
  • POLYTRIM (polymyxin B sulfate and trimethoprim ophthalmic solution, USP) is a sterile antimicrobial solution for topical ophthalmic use. It has pH of 4.0 to 6.2 and osmolality of 270 to 310 mOsm/kg.
  • Trimethoprim is a synthetic antibacterial drug active against a wide variety of aerobic gram-positive and gram-negative ophthalmic pathogens. Trimethoprim blocks the production of tetrahydrofolic acid from dihydrofolic acid by binding to and reversibly inhibiting the enzyme dihydrofolate reductase. This binding is stronger for the bacterial enzyme than for the corresponding mammalian enzyme and therefore selectively interferes with bacterial biosynthesis of nucleic acids and proteins.
  • Polymyxin B, a cyclic lipopeptide antibiotic, is bactericidal for a variety of gram-negative organisms, especially . It increases the permeability of the bacterial cell membrane by interacting with the phospholipid components of the membrane.
  • Blood samples were obtained from 11 human volunteers at 20 minutes, 1 hour and 3 hours following instillation in the eye of 2 drops of ophthalmic solution containing 1 mg trimethoprim and 10,000 units polymyxin B per mL. Peak serum concentrations were approximately 0.03u00b5g/mL trimethoprim and 1 unit/mL polymyxin B.
  • Microbiology:n- In vitro
  • Trimethoprimn- :n- Staphylococcus aureusn- Staphylococcus epidermidis, Streptococcus pyogenes, Streptococcus faecalis, Streptococcus pneumoniae, Haemophilus influenzae, Haemophilus aegyptiusn- , Escherichia coli, Klebsiella pneumoniae, Proteus mirabilisn- , Proteus vulgaris n- , Enterobacter aerogenesn- Serratia marcescens
  • Polymyxin B:n- Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes and Haemophilus influenzae.
  • POLYTRIM Ophthalmic Solution is indicated in the treatment of surface ocular bacterial infections, including acute bacterial conjunctivitis, and blepharoconjunctivitis, caused by susceptible strains of the following microorganisms: , n
  • *Efficacy for this organism in this organ system was studied in fewer than 10 infections.
  • POLYTRIM Ophthalmic Solution is contraindicated in patients with known hypersensitivity to any of its components.
  • NOT FOR INJECTION INTO THE EYE. If a sensitivity reaction to POLYTRIM occurs, discontinue use. POLYTRIM Ophthalmic Solution is not indicated for the prophylaxis or treatment of ophthalmia neonatorum.
  • No data
  • The most frequent adverse reaction to POLYTRIM Ophthalmic Solution is local irritation consisting of increased redness, burning, stinging, and/or itching. This may occur on instillation, within 48 hours, or at any time with extended use. There are also multiple reports of hypersensitivity reactions consisting of lid edema, itching, increased redness, tearing, and/or circumocular rash. Photosensitivity has been reported in patients taking oral trimethoprim.
  • In mild to moderate infections, instill one drop in the affected eye(s) every three hours (maximum of 6 doses per day) for a period of 7 to 10 days.
  • POLYTRIM (polymyxin B sulfate and trimethoprim ophthalmic solution, USP) is supplied sterile in opaque white low density polyethylene ophthalmic dispenser bottles and tips with white high impact polystyrene (HIPS) caps as follows:
  • 10 mL in 10 mL bottle - NDC 0023-7824-10
  • ALLERGAN
  • NDC
  • Rx Only
  • POLYTRIMn- Array
  • 10 mL

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