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Pyridostigmine Bromide (Mestinon)

Trade Name : Mestinon

Bausch Health US, LLC

TABLET

Strength 60 mg/1

PYRIDOSTIGMINE BROMIDE Cholinesterase Inhibitor [EPC],Cholinesterase Inhibitors [MoA]

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Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Pyridostigmine Bromide (Mestinon) which is also known as Mestinon and Manufactured by Bausch Health US, LLC. It is available in strength of 60 mg/1 per ml. Read more

Pyridostigmine Bromide (Mestinon) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials.  Click to know price.     Read less

Packaging and Delivery

Validated Cold Chain Shipment

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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About GNH

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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  • No data
  • MESTINON (pyridostigmine bromide) Oral Solution, USP is an orally active cholinesterase inhibitor. Chemically, pyridostigmine bromide is 3-hydroxy-1-methylpyridinium bromide dimethylcarbamate. Its structural formula is:
  • MESTINON is available in the following forms: containing 60 mg pyridostigmine bromide per teaspoonful in a vehicle containing 5% alcohol, glycerin, lactic acid, sodium benzoate, sorbitol, sucrose, FD & C Red No. 40, FD & C Blue No. 1, flavors and water. containing 60 mg pyridostigmine bromide; each tablet also contains lactose, silicon dioxide and stearic acid. containing 180 mg pyridostigmine bromide; each tablet also contains carnauba wax, corn-derived proteins, magnesium stearate, silica gel and tribasic calcium phosphate.
  • MESTINON inhibits the destruction of acetylcholine by cholinesterase and thereby permits freer transmission of nerve impulses across the neuromuscular junction. Pyridostigmine is an analog of neostigmine (PROSTIGMINu2122), but differs from it in certain clinically significant respects; for example, pyridostigmine is characterized by a longer duration of action and fewer gastrointestinal side effects.
  • MESTINON is useful in the treatment of myasthenia gravis.
  • MESTINON is contraindicated in mechanical intestinal or urinary obstruction, and particular caution should be used in its administration to patients with bronchial asthma. Care should be observed in the use of atropine for counteracting side effects, as discussed below.
  • Although failure of patients to show clinical improvement may reflect underdosage, it can also be indicative of overdosage. As is true of all cholinergic drugs, overdosage of MESTINON may result in cholinergic crisis, a state characterized by increasing muscle weakness which, through involvement of the muscles of respiration, may lead to death. Myasthenic crisis due to an increase in the severity of the disease is also accompanied by extreme muscle weakness, and thus may be difficult to distinguish from cholinergic crisis on a symptomatic basis. Such differentiation is extremely important, since increases in doses of MESTINON or other drugs of this class in the presence of cholinergic crisis or of a refractory or u201cinsensitiveu201d state could have grave consequences. Osserman and Genkins indicate that the differential diagnosis of the two types of crisis may require the use of TENSILONu2122 (edrophonium chloride) as well as clinical judgment. The treatment of the two conditions obviously differs radically. Whereas the presence of myasthenic crisis suggests the need for more intensive anticholinesterase therapy, the diagnosis of cholinergic crisis, according to Osserman and Genkins, calls for the prompt of all drugs of this type. The immediate use of atropine in cholinergic crisis is also recommended.
  • Atropine may also be used to abolish or obtund gastrointestinal side effects or other muscarinic reactions; but such use, by masking signs of overdosage, can lead to inadvertent induction of cholinergic crisis.
  • For detailed information on the management of patients with myasthenia gravis, the physician is referred to one of the excellent reviews such as those by Osserman and Genkins, Grob or Schwab.n
  • The safety of MESTINON during pregnancy or lactation in humans has not been established. Therefore, use of MESTINON in women who may become pregnant requires weighing the drugu2019s potential benefits against its possible hazards to mother and child.
  • Pyridostigmine is mainly excreted unchanged by the kidney. Therefore, lower doses may be required in patients with renal disease, and treatment should be based on titration of drug dosage to effect.n
  • Safety and effectiveness in pediatric patients have not been established.
  • The side effects of MESTINON are most commonly related to overdosage and generally are of two varieties, muscarinic and nicotinic. Among those in the former group are nausea, vomiting, diarrhea, abdominal cramps, increased peristalsis, increased salivation, increased bronchial secretions, miosis and diaphoresis. Nicotinic side effects are comprised chiefly of muscle cramps, fasciculation and weakness. Muscarinic side effects can usually be counteracted by atropine, but for reasons shown in the preceding section the expedient is not without danger. As with any compound containing the bromide radical, a skin rash may be seen in an occasional patient. Such reactions usually subside promptly upon discontinuance of the medication.
  • To report SUSPECTED ADVERSE REACTIONS, contact Bausch Health US, LLC, at 1-800-321-4576 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
  • MESTINON is available in three dosage forms:
  • Oral Solution,
  • Tablets,
  • TIMESPAN tablets,n- Note
  • Store MESTINON (pyridostigmine bromide) Oral Solution, USP, Tablets, and TIMESPAN tablets at 25u00b0C (77u00b0F); excursions permitted to 15u00b0-30u00b0C (59u00b0-86u00b0F).
  • No data
  • Manufactured for:
  • NDCn- Rx Only
  • Mestinonn- Oral Solution,USP
  • 1 Pint (473 mL)5 mL =60 mg
  • 5 mL (1 teaspoonful) contains n n- pyridostigmine bromide.
  • Alcohol 5%
  • BAUSCH Health
  • NDC 0187-3010-30n- Rx Onlyn- Pull here
  • Mestinon
  • 60 mg
  • Each tablet contains 60 mgpyridostigminebromide
  • Arrayn- Array
  • VALEANTPharmaceuticals North America LLC
  • NDCn- Rx Onlyn Pull here
  • Mestinon
  • 180 mg
  • Each tabletn- contains180 mgn- pyridostigminen- bromiden- in a speciallyn- constructed tablet forn- sustained release
  • Arrayn- Array
  • VALEANT

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