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Tigecycline (Tygacil)

Trade Name : Tygacil

Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc.

INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION

Strength 50 mg/5mL

TIGECYCLINE Tetracycline-class Antibacterial [EPC],Tetracyclines [CS]

Delivery Process

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Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Tigecycline (Tygacil) which is also known as Tygacil and Manufactured by Wyeth Pharmaceuticals LLC, a subsidiary of Pfizer Inc.. It is available in strength of 50 mg/5mL per ml. Read more

Tigecycline (Tygacil) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials.  Click to know price.     Read less

Packaging and Delivery

Validated Cold Chain Shipment

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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About GNH

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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  • No data
  • An increase in all-cause mortality has been observed in a meta-analysis of Phase 3 and 4 clinical trials in TYGACIL-treated patients versus comparator. The cause of this mortality risk difference of 0.6% (95% CI 0.1, 1.2) has not been established. TYGACIL should be reserved for use in situations when alternative treatments are not suitable n
  • WARNING: ALL-CAUSE MORTALITY
  • See full prescribing information for complete boxed warning.
  • All-cause mortality was higher in patients treated with TYGACIL than comparators in a meta-analysis of clinical trials. The cause of this mortality risk difference of 0.6% (95% CI 0.1, 1.2) has not been established. TYGACIL should be reserved for use in situations when alternative treatments are not suitable n
  • TYGACIL is a tetracycline class antibacterial indicated in patients 18 years of age and older for:
  • Limitations of Use: TYGACIL is not indicated for treatment of diabetic foot infection or hospital-acquired pneumonia, including ventilator-associated pneumonia ().
  • To reduce the development of drug-resistant bacteria and maintain the effectiveness of TYGACIL and other antibacterial drugs, TYGACIL should be used only to treat infections that are proven or strongly suspected to be caused by bacteria.
  • Complicated skin and skin structure infections ()
  • Complicated intra-abdominal infections ()
  • Community-acquired bacterial pneumonia ()
  • No data
  • Initial dose of 100 mg, followed by 50 mg every 12 hours administered intravenously over approximately 30 to 60 minutes. ()
  • Severe hepatic impairment (Child Pugh C): Initial dose of 100 mg followed by 25 mg every 12 hours. ()
  • For Injection: Each single-dose 5 mL glass vial and 10 mL glass vial contain 50 mg of tigecycline as an orange lyophilized powder for reconstitution.
  • For Injection: 50 mg, lyophilized powder for reconstitution in a single-dose 5 mL vial or 10 mL vial. ()
  • TYGACIL is contraindicated for use in patients who have known hypersensitivity to tigecycline. Reactions have included anaphylactic reactions n
  • Known hypersensitivity to tigecycline. ()
  • No data
  • All-Cause Mortality
  • Anaphylactic Reactions
  • Hepatic Adverse n- Effects
  • Pancreatitis
  • Fetal Harm
  • Tooth Discoloration
  • Arrayn- associated Diarrhea (CDAD)
  • The following serious adverse reactions are described elsewhere in the labeling:
  • The most common adverse reactions (incidence >5%) are nausea, vomiting, diarrhea, abdominal pain, headache, and increased SGPT. ()
  • No data
  • Suitable anticoagulation test should be monitored if TYGACIL is administered to patients receiving warfarin. ()
  • No data
  • Pediatrics: Use in patients under 18 years of age is not recommended. Pediatric trials were not conducted because of the higher risk of mortality seen in adult trials ()
  • No specific information is available on the treatment of overdosage with tigecycline. Intravenous administration of TYGACIL at a single dose of 300 mg over 60 minutes in healthy volunteers resulted in an increased incidence of nausea and vomiting. Tigecycline is not removed in significant quantities by hemodialysis.
  • TYGACIL (tigecycline) is a tetracycline class antibacterial for intravenous infusion. The chemical name of tigecycline is (4,4a,5a,12a)-9-[2-(-butylamino)acetamido]-4,7-bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide. The empirical formula is CHNO and the molecular weight is 585.65.
  • The following represents the chemical structure of tigecycline:
  • TYGACIL is an orange lyophilized powder or cake. Each TYGACIL single-dose 5 mL or 10 mL vial contains 50 mg tigecycline lyophilized powder for reconstitution for intravenous infusion and 100 mg of lactose monohydrate. The pH is adjusted with hydrochloric acid, and if necessary sodium hydroxide. The product does not contain preservatives.
  • No data
  • No data
  • No data
  • TYGACIL (tigecycline) for injection is supplied in a single-dose 5 mL glass vial or 10 mL glass vial, each containing 50 mg tigecycline lyophilized powder for reconstitution.
  • Supplied:
  • 5 mL - 10 vials/box. NDC 0008-4994-02
  • 10 mL - 10 vials/box. NDC 0008-4994-20
  • Prior to reconstitution, TYGACIL should be stored at 20u00b0 to 25u00b0C (68u00b0 to 77u00b0F); excursions permitted to 15u00b0 to 30u00b0C (59u00b0 to 86u00b0F). [See USP Controlled Room Temperature.] The reconstituted solution of TYGACIL may be stored at room temperature (not to exceed 25u00b0C/77u00b0F) for up to 24 hours (up to 6 hours in the vial and the remaining time in the intravenous bag) .
  • No data
  • This product's label may have been updated. For current full prescribing information, please visit .
  • Distributed byWyeth Pharmaceuticals LLCA subsidiary of Pfizer IncPhiladelphia, PA 19101
  • PREMIERProRx is a registered trademark of Premier Healthcare Alliance, L.P., used under license.
  • LAB-0794-3.0
  • NDC 0008-4994-19
  • Single Use Vial
  • Tygaciln (tigecycline) for injection
  • 50 mg
  • tigecycline per vial For I.V. Infusion Only
  • 10 Single Use Vials
  • NDC 0008-4994-20 Contains 10 of NDC 0008-4994-19 Rx only
  • Tygaciln (tigecycline) for injection
  • 50 mg
  • tigecycline per vial
  • RECONSTITUTED SOLUTION MUST BE FURTHER DILUTED FOR I.V. INFUSION
  • PREMIERProRxn

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Validated Cold Chain Shipment

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