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Tobramycin And Dexamethasone (Tobradex)

Trade Name : TobraDex

Alcon Laboratories, Inc.

SUSPENSION/ DROPS

Strength 31 mg/mLmg/mL

TOBRAMYCIN; DEXAMETHASONE Aminoglycoside Antibacterial [EPC],Aminoglycosides [CS],Corticosteroid [EPC],Corticosteroid Hormone Receptor Agonists [MoA]

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Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Tobramycin And Dexamethasone (Tobradex) which is also known as TobraDex and Manufactured by Alcon Laboratories, Inc.. It is available in strength of 3; 1 mg/mL; mg/mL per ml. Read more

Tobramycin And Dexamethasone (Tobradex) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials.  Click to know price.     Read less

Packaging and Delivery

Validated Cold Chain Shipment

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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About GNH

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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  • No data
  • DESCRIPTION:
  • The chemical structures for tobramycin and dexamethasone are presented below:
  • Tobramycin
  • Empirical Formula: CHNOn
  • Chemical Name: -3-Amino-3-deoxy-u03b1-D-glucopyranosyl-(1u21924)--[2,6-diamino-2,3,6-trideoxy-u03b1-D--hexopyranosyl-(1u21926)]-2-deoxy-L-streptamine
  • Dexamethasone
  • Empirical Formula: CHFOn
  • Chemical Name: 9-Fluoro-11u03b2,17,21-trihydroxy-16u03b1-methylpregna-1,4-diene-3,20-dione
  • Each mL of TOBRADEXn n- contains: Actives: n- Preservative: n- Inactives:
  • CLINICAL PHARMACOLOGY:
  • The antibiotic component in the combination (tobramycin) is included to provide action against susceptible organisms. studies have demonstrated that tobramycin is active against susceptible strains of the following microorganisms:
  • Staphylococci, including and (coagulase-positive and coagulase-negative), including penicillin-resistant strains.
  • Streptococci, including some of the Group A-beta-hemolytic species, some nonhemolytic species, and some n
  • Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus mirabilis, Morganella morganii, n- Proteus vulgaris n- Haemophilus influenzae n- H. aegyptius, Moraxella lacunata, Acinetobacter calcoaceticus n- Neisseria
  • Bacterial susceptibility studies demonstrate that in some cases microorganisms resistant to gentamicin remain susceptible to tobramycin.
  • No data are available on the extent of systemic absorption from TOBRADEX (tobramycin and dexamethasone ophthalmic suspension); however, it is known that some systemic absorption can occur with ocularly applied drugs. If the maximum dose of TOBRADEX (tobramycin and dexamethasone ophthalmic suspension) is given for the first 48 hours (two drops in each eye every 2 hours) and complete systemic absorption occurs, which is highly unlikely, the daily dose of dexamethasone would be 2.4 mg. The usual physiologic replacement dose is 0.75 mg daily. If TOBRADEX (tobramycin and dexamethasone ophthalmic suspension) is given after the first 48 hours as two drops in each eye every 4 hours, the administered dose of dexamethasone would be 1.2 mg daily.
  • INDICATIONS AND USAGE:
  • Ocular steroids are indicated in inflammatory conditions of the palpebral and bulbar conjunctiva, cornea and anterior segment of the globe where the inherent risk of steroid use in certain infective conjunctivitides is accepted to obtain a diminution in edema and inflammation. They are also indicated in chronic anterior uveitis and corneal injury from chemical, radiation or thermal burns, or penetration of foreign bodies.
  • The use of a combination drug with an anti-infective component is indicated where the risk of superficial ocular infection is high or where there is an expectation that potentially dangerous numbers of bacteria will be present in the eye.
  • The particular anti-infective drug in this product is active against the following common bacterial eye pathogens:
  • Staphylococci, including and (coagulase-positive and coagulase-negative), including penicillin-resistant strains.
  • Streptococci, including some of the Group A-beta-hemolytic species, some nonhemolytic species, and some n
  • Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus mirabilis, Morganella morganii, n- Proteus vulgaris n- Haemophilus influenzae n- H. aegyptius, Moraxella lacunata, Acinetobacter calcoaceticus n- Neisseria
  • CONTRAINDICATIONS:
  • WARNINGS:
  • Prolonged use of steroids may result in glaucoma, with damage to the optic nerve, defects in visual acuity and fields of vision, and posterior subcapsular cataract formation. Intraocular pressure should be routinely monitored even though it may be difficult in pediatric patients and uncooperative patients. Prolonged use may suppress the host response and thus increase the hazard of secondary ocular infections.
  • In those diseases causing thinning of the cornea or sclera, perforations have been known to occur with the use of topical steroids. In acute purulent conditions of the eye, steroids may mask infection or enhance existing infection.
  • No data
  • ADVERSE REACTIONS:
  • n Secondary Infection. The development of secondary infection has occurred after use of combinations containing steroids and antimicrobials. Fungal infections of the cornea are particularly prone to develop coincidentally with long-term applications of steroids. The possibility of fungal invasion must be considered in any persistent corneal ulceration where steroid treatment has been used. Secondary bacterial ocular infection following suppression of host responses also occurs.
  • OVERDOSAGE:
  • u00ae
  • DOSAGE AND ADMINISTRATION:
  • Not more than 20 mL should be prescribed initially and the prescription should not be refilled without further evaluation as outlined in PRECAUTIONS above.
  • HOW SUPPLIED: n- NDC
  • STORAGE:
  • Store suspension upright and shake well before using.
  • Rx Only
  • u00a9 2002, 2006, 2015, 2018 Novartis
  • Distributed By:ALCON LABORATORIES, INC.Fort Worth, Texas 76134
  • Alconn A Novartis company
  • Revised: May 2018T2018-52
  • No data

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Comparator Sourcing for Clinical Trials

Comparator Sourcing for Clinical Trials

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Validated Cold Chain Shipment

Validated Cold Chain Shipment

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