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Tobramycin (Tobrex)

Trade Name : Tobrex

Alcon Laboratories, Inc.

SOLUTION/ DROPS

Strength 3 mg/mL

TOBRAMYCIN Aminoglycoside Antibacterial [EPC],Aminoglycosides [CS]

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Product information is meant for

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Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Tobramycin (Tobrex) which is also known as Tobrex and Manufactured by Alcon Laboratories, Inc.. It is available in strength of 3 mg/mL per ml. Read more

Tobramycin (Tobrex) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials.  Click to know price.     Read less

Packaging and Delivery

Validated Cold Chain Shipment

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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About GNH

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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  • No data
  • TOBREX (tobramycin ophthalmic solution) 0.3% is a sterile topical ophthalmic antibiotic formulation prepared specifically for topical therapy of external ophthalmic infections.
  • Each mL of TOBREX (tobramycin ophthalmic solution) 0.3% contains: tobramycin 0.3% (3 mg). benzalkonium chloride 0.01% (0.1 mg). boric acid, sodium sulfate, sodium chloride, tyloxapol, sodium hydroxide and/or sulfuric acid (to adjust pH) and purified water. TOBREX (tobramycin ophthalmic solution) 0.3% has a pH range between 7.0 and 8.0 and an osmolality of 260-320 mOsm/kg.
  • Tobramycin is a water-soluble aminoglycoside antibiotic active against a wide variety of gram-negative and gram-positive ophthalmic pathogens.
  • The chemical structure of tobramycin is:
  • Molecular Weight = 467.52
  • Molecular Formula: CHNOn
  • Chemical Name: 0-{3-amino-3-deoxy-u03b1-D-gluco-pyranosyl-(1u21924) }-0-{2,6-diamino-2,3,6-trideoxy-u03b1-D-ribohexo-pyranosyl-(1u21926) }-2-deoxystreptamine.
  • In Vitro Data: In vitro n- S. aureus n- S. epidermidis
  • Streptococci, including some of the Group A-beta-hemolytic species, some nonhemolytic species, and some .
  • Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus mirabilis, Morganella morganiin- Proteus vulgaris n- Haemophilus influenzae n- H. aegyptius, Moraxella lacunatan- Acinetobacter calcoaceticus n- Neisseria
  • TOBREX (tobramycin ophthalmic solution) 0.3% is a topical antibiotic indicated in the treatment of external infections of the eye and its adnexa caused by susceptible bacteria. Appropriate monitoring of bacterial response to topical antibiotic therapy should accompany the use of TOBREX. Clinical studies have shown tobramycin to be safe and effective for use in children.
  • TOBREX (tobramycin ophthalmic solution) 0.3% is contraindicated in patients with known hypersensitivity to any of its components.
  • FOR TOPICAL OPHTHALMIC USE ONLY. NOT FOR INJECTION INTO THE EYE. Sensitivity to topically applied aminoglycosides may occur in some patients. If a sensitivity reaction to TOBREX (tobramycin ophthalmic solution) 0.3% occurs, discontinue use.
  • No data
  • The most frequent adverse reactions to TOBREX Ophthalmic Solution are hypersensitivity and localized ocular toxicity, including lid itching and swelling, and conjunctival erythema. These reactions occur in less than three of 100 patients treated with TOBREX. Similar reactions may occur with the topical use of other aminoglycoside antibiotics. Other adverse reactions have not been reported from TOBREX (tobramycin ophthalmic solution) 0.3% therapy; however, if topical ocular tobramycin is administered concomitantly with systemic aminoglycoside antibiotics, care should be taken to monitor the total serum concentration.
  • Clinically apparent signs and symptoms of an overdose of TOBREX (tobramycin ophthalmic solution) 0.3% (punctate keratitis, erythema, increased lacrimation, edema and lid itching) may be similar to adverse reaction effects seen in some patients.
  • In mild to moderate disease, instill one or two drops into the affected eye(s) every four hours. In severe infections, instill two drops into the eye(s) hourly until improvement, following which treatment should be reduced prior to discontinuation.
  • 5 mL sterile solution is packaged in a 8 mL low density polyethylene white DROP-TAINER bottle and natural dispensing plug and white polypropylene closure (NDC 0065-0643-05) containing tobramycin 0.3% (3 mg/mL).
  • Storage:
  • Rx Only
  • n u00a9 2000-2003, 2012, 2018 NovartisRevised: April 2018n n
  • Distributed by:
  • ALCON LABORATORIES, INC.n
  • T2018-31
  • No data
  • No data

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