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Tobramycin (Tobrex)

Trade Name : TOBREX

Alcon Laboratories, Inc.

OINTMENT

Strength 3 mg/g

TOBRAMYCIN Aminoglycoside Antibacterial [EPC],Aminoglycosides [CS]

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Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Tobramycin (Tobrex) which is also known as TOBREX and Manufactured by Alcon Laboratories, Inc.. It is available in strength of 3 mg/g per ml. Read more

Tobramycin (Tobrex) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials.  Click to know price.     Read less

Packaging and Delivery

Validated Cold Chain Shipment

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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  • No data
  • TOBREX (tobramycin ophthalmic ointment) 0.3% is a sterile topical ophthalmic antibiotic formulation prepared specifically for topical therapy of external ophthalmic infections.
  • Each gram of TOBREX (tobramycin ophthalmic ointment) 0.3% contains: Active: n- Preservative: n- Inactives:
  • Tobramycin is a water-soluble aminoglycoside antibiotic active against a wide variety of gram-negative and gram-positive ophthalmic pathogens.
  • The chemical structure of tobramycin is:
  • Molecular Formula:
  • CHNOn
  • Molecular Weight: 467.52
  • Chemical Name:
  • 0-{3-amino-3-deoxy-u03b1-D-gluco-pyranosyl-(1u21924) }-0-{2,6-diamino-2,3,6-trideoxy-u03b1-D-ribohexo-pyranosyl-(1u21926) }-2-deoxystreptamine.
  • In Vitro Data: In vitron- S. aureusn- S. epidermidis
  • Streptococci, including some of the Group A-beta-hemolytic species, some nonhemolytic species, and some .
  • Pseudomonas aeruginosan- Escherichia coli, Klebsiella pneumoniaen- Enterobacter aerogenesn- Proteus mirabilisn- Morganella morganiin- Proteus vulgarisn- Haemophilus influenzaen- H. aegyptiusn- Moraxella lacunatan- Acinetobacter calcoaceticusn- Neisseria species
  • TOBREX (tobramycin ophthalmic ointment) 0.3 % is a topical antibiotic indicated in the treatment of external infections of the eye and its adnexa caused by susceptible bacteria. Appropriate monitoring of bacterial response to topical antibiotic therapy should accompany the use of TOBREX (tobramycin ophthalmic ointment) 0.3%. Clinical studies have shown tobramycin to be safe and effective for use in children.
  • TOBREX (tobramycin ophthalmic ointment) 0.3 % is contraindicated in patients with known hypersensitivity to any of its components.
  • NOT FOR INJECTION INTO THE EYE. Sensitivity to topically applied aminoglycosides may occur in some patients. If a sensitivity reaction to TOBREX (tobramycin ophthalmic ointment) 0.3% occurs, discontinue use.
  • General:
  • Cross-sensitivity to other aminoglycoside antibiotics may occur; if hypersensitivity develops with this product, discontinue use and institute appropriate therapy.
  • Patients should be advised not to wear contact lenses if they have signs and symptoms of ocular infections.
  • The most frequent adverse reactions to TOBREX (tobramycin ophthalmic ointment) 0.3% are hypersensitivity and localized ocular toxicity, including lid itching and swelling, and conjunctival erythema. These reactions occur in less than three of 100 patients treated with TOBREX (tobramycin ophthalmic ointment) 0.3%. Similar reactions may occur with the topical use of other aminoglycoside antibiotics. Other adverse reactions have not been reported from TOBREX (tobramycin ophthalmic ointment) 0.3% therapy; however, if topical ocular tobramycin is administered concomitantly with systemic aminoglycoside antibiotics, care should be taken to monitor the total serum concentration. In clinical trials, TOBREX (tobramycin ophthalmic ointment) 0.3 % produced significantly fewer adverse reactions (3.7%) than did GARAMYCIN Ophthalmic Ointment (10.6%).
  • Clinically apparent signs and symptoms of an overdose of TOBREX (tobramycin ophthalmic ointment) 0.3% (punctate keratitis, erythema, increased lacrimation, edema and lid itching) may be similar to adverse reaction effects seen in some patients.
  • In mild to moderate disease, apply a half-inch ribbon into the affected eye(s) two or three times per day. In severe infections, instill a half-inch ribbon into the affected eye(s) every three to four hours until improvement, following which treatment should be reduced prior to discontinuation.
  • How to Apply TOBREX (tobramycin ophthalmic ointment) 0.3%:
  • 1. Tilt your head back.
  • 2. Place a finger on your cheek just under your eye and gently pull down until a ''V'' pocket is formed between your eyeball and your lower lid.
  • 3. Place a small amount (about u00bd inch) of TOBREX (tobramycin ophthalmic ointment) 0.3% in the ''V'' pocket. Do not let the tip of the tube touch your eye.
  • 4. Look downward before closing your eye.
  • 3.5 g STERILE ointment supplied in an aluminum tube with a white polyethylene tip and white polyethylene cap (0065-0644-35), containing tobramycin 0.3% (3 mg/g).
  • Storage:
  • Rx Only
  • u00a9 2002, 2018 Alcon, Inc.
  • Revised: April 2018
  • Distributed by:
  • ALCON LABORATORIES, INC.
  • Fort Worth, Texas 76134 USA
  • Alconn
  • A Novartis company
  • Manufactured by:
  • S.A. ALCON-COUVREUR N.V.
  • Puurs, Belgium
  • T2018-30
  • NDC
  • Tobrex
  • (tobramycin ophthalmic
  • ointment) 0.3%
  • Sterile 3.5 g Net Wt.

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Comparator Sourcing for Clinical Trials

Comparator Sourcing for Clinical Trials

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Validated Cold Chain Shipment

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