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Torsemide (Demadex)

Trade Name : Demadex

Meda Pharmaceuticals

TABLET

Strength 100 mg/1

TORSEMIDE Increased Diuresis at Loop of Henle [PE],Loop Diuretic [EPC]

Delivery Process

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Product information is meant for

Wholesalers Suppliers Exporters Doctors MOH Tender Supplies Hospitals Brand CROs Comparator Supplies Generic Cooperate Sourcing Individual Patients Indian Institutional Buyers

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Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Torsemide (Demadex) which is also known as Demadex and Manufactured by Meda Pharmaceuticals. It is available in strength of 100 mg/1 per ml. Read more

Torsemide (Demadex) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials.  Click to know price.     Read less

Packaging and Delivery

Validated Cold Chain Shipment

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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About GNH

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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  • No data
  • DEMADEX is a loop diuretic indicated for:
  • Edema associated with:
  • Hypertension:
  • DEMADEX is available as white scored tablets in 5-, 10-, 20-, and 100-mg strengths.
  • Tablets: 5 mg, 10 mg, 20 mg and 100 mg ()
  • DEMADEX is contraindicated in patients with known hypersensitivity to DEMADEX or to povidone.
  • DEMADEX is contraindicated in patients who are anuric.
  • DEMADEX is contraindicated in patients with hepatic coma.
  • Hypersensitivity to DEMADEX or povidone, anuria, and hepatic coma. ()
  • No data
  • 5.3n- 7.6
  • The following risks are discussed in more detail in other sections:
  • The most common adverse reaction is excessive urination (6.7%). ()
  • To report SUSPECTED ADVERSE REACTIONS, contact Meda Pharmaceuticals Inc. at 1-800-526-3840 or FDA at 1-800-FDA-1088 or n
  • No data
  • No data
  • The signs and symptoms of overdosage can be anticipated to include those of excessive pharmacologic effect: dehydration, hypovolemia, hypotension, hyponatremia, hypokalemia, hypochloremic alkalosis, and hemoconcentration. Treatment of overdosage should consist of fluid and electrolyte replacement.
  • Laboratory determinations of serum levels of torsemide and its metabolites are not widely available.
  • No data are available to suggest physiological maneuvers (e.g., maneuvers to change the pH of the urine) that might accelerate elimination of torsemide and its metabolites. Torsemide is not dialyzable, so hemodialysis will not accelerate elimination.
  • DEMADEX (torsemide) is a diuretic of the pyridine-sulfonylurea class. Its chemical name is 1-isopropyl-3-[(4--toluidino-3-pyridyl) sulfonyl] urea and its structural formula is:
  • Its empirical formula is CHNOS, its pKa is 7.1, and its molecular weight is 348.43.
  • Torsemide is a white to off-white crystalline powder. The tablets for oral administration also contain lactose NF, crospovidone NF, povidone USP, microcrystalline cellulose NF, and magnesium stearate NF.
  • No data
  • No overall increase in tumor incidence was found when torsemide was given to rats and mice throughout their lives at doses up to 9 mg/kg/day (rats) and 32 mg/kg/day (mice). On a body-weight basis, these doses are 27 to 96 times a human dose of 20 mg; on a body-surface-area basis, they are 5 to 8 times this dose. In the rat study, the high-dose female group demonstrated renal tubular injury, interstitial inflammation, and a statistically significant increase in renal adenomas and carcinomas. The tumor incidence in this group was, however, not much higher than the incidence sometimes seen in historical controls. Similar signs of chronic non-neoplastic renal injury have been reported in high-dose animal studies of other diuretics such as furosemide and hydrochlorothiazide.
  • No mutagenic activity was detected in any of a variety of in vivo and in vitro tests of torsemide and its major human metabolite. The tests included the Ames test in bacteria (with and without metabolic activation), tests for chromosome aberrations and sister-chromatid exchanges in human lymphocytes, tests for various nuclear anomalies in cells found in hamster and murine bone marrow, tests for unscheduled DNA synthesis in mice and rats, and others.
  • In doses up to 25 mg/kg/day (75 times a human dose of 20 mg on a body-weight basis; 13 times this dose on a body-surface-area basis), torsemide had no adverse effect on the reproductive performance of male or female rats.
  • DEMADEX for oral administration is available as white, scored tablets as follows:
  • Symptomatic Hypotension:u00a0
  • All patients should be cautioned that inadequate fluid intake, excessive perspiration, diarrhea, or vomiting can lead to an excessive fall in blood pressure, with the same consequences of lightheadedness and possible syncope n
  • Non-Steroidal Anti-inflammatory Drugs (NSAID):n- [see ].
  • MEDA PHARMACEUTICALS and DEMADEX are registered trademarks of Meda AB. Any other trademarks are the property of their respective owners.
  • Manufactured By: Meda Manufacturing GmbH, Cologne, GermanyFor: Meda PharmaceuticalsMeda Pharmaceuticals Inc.Somerset, NJ 08873-4120
  • Made in Germany
  • Printed in USA
  • u00a9 2017 Meda Pharmaceuticals Inc.
  • IN-3500-02
  • NDC 0037-3510-01 u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0100 Tablets
  • DEMADEXu00ae
  • (torsemide)
  • 10 mg
  • MEDAu00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0Rx only
  • NDC 0037-3520-01 u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0100 Tablets
  • DEMADEXu00ae
  • (torsemide)
  • 20 mg
  • MEDAu00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0Rx only
  • NDC 0037-3500-01 u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0100 Tablets
  • DEMADEXu00ae
  • (torsemide)
  • 100 mg
  • MEDAu00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0Rx only

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