Torsemide (Demadex)

Trade Name : Demadex

Meda Pharmaceuticals

TABLET

Strength 100 mg/1

Storage and handling for Demadex

TORSEMIDE Increased Diuresis at Loop of Henle [PE],Loop Diuretic [EPC]

Disclaimer

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Torsemide (Demadex) which is also known as Demadex and Manufactured by Meda Pharmaceuticals. It is available in strength of 100 mg/1 per ml. Read more

Torsemide (Demadex) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials.  Click to know price.     Read less

Delivery Process

Submit a Request

You can fill in a request for your medicine through the form provided. You can access the form by clicking on the ‘Get Price’ button.

We’ll Get in Touch

Once we review your request, we’ll send you an estimated price for the medicine within 2-5 days.

Confirmation and Payment

You can fill in a request for your medicine through the form provided. You can access the form by clicking on the ‘Get Price’ button.

Submit a Request

You can fill in a request for your medicine through the form provided. You can access the form by clicking on the ‘Get Price’ button.

Packaging and Delivery

Validated Cold Chain Shipment

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

Read more

About GNH

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

Read more
  • No data
  • DEMADEX is a loop diuretic indicated for:
  • Edema associated with:
  • Hypertension:
  • DEMADEX is available as white scored tablets in 5-, 10-, 20-, and 100-mg strengths.
  • Tablets: 5 mg, 10 mg, 20 mg and 100 mg ()
  • DEMADEX is contraindicated in patients with known hypersensitivity to DEMADEX or to povidone.
  • DEMADEX is contraindicated in patients who are anuric.
  • DEMADEX is contraindicated in patients with hepatic coma.
  • Hypersensitivity to DEMADEX or povidone, anuria, and hepatic coma. ()
  • No data
  • 5.3n- 7.6
  • The following risks are discussed in more detail in other sections:
  • The most common adverse reaction is excessive urination (6.7%). ()
  • To report SUSPECTED ADVERSE REACTIONS, contact Meda Pharmaceuticals Inc. at 1-800-526-3840 or FDA at 1-800-FDA-1088 or n
  • No data
  • No data
  • The signs and symptoms of overdosage can be anticipated to include those of excessive pharmacologic effect: dehydration, hypovolemia, hypotension, hyponatremia, hypokalemia, hypochloremic alkalosis, and hemoconcentration. Treatment of overdosage should consist of fluid and electrolyte replacement.
  • Laboratory determinations of serum levels of torsemide and its metabolites are not widely available.
  • No data are available to suggest physiological maneuvers (e.g., maneuvers to change the pH of the urine) that might accelerate elimination of torsemide and its metabolites. Torsemide is not dialyzable, so hemodialysis will not accelerate elimination.
  • DEMADEX (torsemide) is a diuretic of the pyridine-sulfonylurea class. Its chemical name is 1-isopropyl-3-[(4--toluidino-3-pyridyl) sulfonyl] urea and its structural formula is:
  • Its empirical formula is CHNOS, its pKa is 7.1, and its molecular weight is 348.43.
  • Torsemide is a white to off-white crystalline powder. The tablets for oral administration also contain lactose NF, crospovidone NF, povidone USP, microcrystalline cellulose NF, and magnesium stearate NF.
  • No data
  • No overall increase in tumor incidence was found when torsemide was given to rats and mice throughout their lives at doses up to 9 mg/kg/day (rats) and 32 mg/kg/day (mice). On a body-weight basis, these doses are 27 to 96 times a human dose of 20 mg; on a body-surface-area basis, they are 5 to 8 times this dose. In the rat study, the high-dose female group demonstrated renal tubular injury, interstitial inflammation, and a statistically significant increase in renal adenomas and carcinomas. The tumor incidence in this group was, however, not much higher than the incidence sometimes seen in historical controls. Similar signs of chronic non-neoplastic renal injury have been reported in high-dose animal studies of other diuretics such as furosemide and hydrochlorothiazide.
  • No mutagenic activity was detected in any of a variety of in vivo and in vitro tests of torsemide and its major human metabolite. The tests included the Ames test in bacteria (with and without metabolic activation), tests for chromosome aberrations and sister-chromatid exchanges in human lymphocytes, tests for various nuclear anomalies in cells found in hamster and murine bone marrow, tests for unscheduled DNA synthesis in mice and rats, and others.
  • In doses up to 25 mg/kg/day (75 times a human dose of 20 mg on a body-weight basis; 13 times this dose on a body-surface-area basis), torsemide had no adverse effect on the reproductive performance of male or female rats.
  • DEMADEX for oral administration is available as white, scored tablets as follows:
  • Symptomatic Hypotension:u00a0
  • All patients should be cautioned that inadequate fluid intake, excessive perspiration, diarrhea, or vomiting can lead to an excessive fall in blood pressure, with the same consequences of lightheadedness and possible syncope n
  • Non-Steroidal Anti-inflammatory Drugs (NSAID):n- [see ].
  • MEDA PHARMACEUTICALS and DEMADEX are registered trademarks of Meda AB. Any other trademarks are the property of their respective owners.
  • Manufactured By: Meda Manufacturing GmbH, Cologne, GermanyFor: Meda PharmaceuticalsMeda Pharmaceuticals Inc.Somerset, NJ 08873-4120
  • Made in Germany
  • Printed in USA
  • u00a9 2017 Meda Pharmaceuticals Inc.
  • IN-3500-02
  • NDC 0037-3510-01 u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0100 Tablets
  • DEMADEXu00ae
  • (torsemide)
  • 10 mg
  • MEDAu00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0Rx only
  • NDC 0037-3520-01 u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0100 Tablets
  • DEMADEXu00ae
  • (torsemide)
  • 20 mg
  • MEDAu00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0Rx only
  • NDC 0037-3500-01 u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0100 Tablets
  • DEMADEXu00ae
  • (torsemide)
  • 100 mg
  • MEDAu00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0u00a0Rx only

Browse Our Services And Processes

Comparator Sourcing for Clinical Trials

Comparator Sourcing for Clinical Trials

GNH India brings over 10 years of experience in Comparator

Read More

Name Patient Supply

Name Patient Supply

Today, the exact cause for many rare diseases remains unknown

Read More

Validated Cold Chain Shipment

Validated Cold Chain Shipment

With shifting of pharma industry from synthetic molecules to biologic

Read More

Clinical Trials Supply

Clinical Trials Supply

STOP SOURCING..... START SMART SOURCING...... COME STRAIGHT TO THE SOURCE

Read More

Dossiers and Stability Studies

Dossiers and Stability Studies

STABILITY STUDIES STABILITY, BA / BE STUDIES Due to our active

Read More

Pharmaceutical Contract Manufacturing

Pharmaceutical Contract Manufacturing

GNH Provides Contract Manufacturing services for: Generic Medicines with following

Read More

Pricing

Pricing

PRICING POLICY Terms of sales are typically prepaid, unless otherwise

Read More

Disclaimer

Please see the Legal Notice for detailed terms and disclaimers. The Legal Notice governs the use of this Website and by accessing and using this Website you agree to be bound by and accept the Legal Notice.

Browse from other international pharmaceuticals

General

64036 Products

GNH India brings over 10 years of experience in Comparator Sourcing services from India and RoW markets.

US NDC

71256 Products

GNH India brings over 10 years of experience in Comparator Sourcing services from India and RoW markets.

Canadian DIN

51047 Products

GNH India brings over 10 years of experience in Comparator Sourcing services from India and RoW markets.

Swiss Drugs

150 Products

GNH India brings over 10 years of experience in Comparator Sourcing services from India and RoW markets.

NZ Drugs

13298 Products

GNH India brings over 10 years of experience in Comparator Sourcing services from India and RoW markets.

FAQ

Check out our delivery process

Can’t find what
you’re looking for?

Contact US
Pharmexcil
DB
FIEO-2016
SiteLock

Copyright © 2022 GNHIndia .com. All Rights Reserved. Please read Legal Notice for further details.

Disclaimer: Product names, logos, brands and other trademarks featured or referred to are the property of their respective trademark holders.