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Trimethadione (Tridione)

Trade Name : Tridione

AbbVie Inc.

TABLET, CHEWABLE

Strength 150 mg/1

TRIMETHADIONE Decreased Central Nervous System Disorganized Electrical Activity [PE],Anti-epileptic Agent [EPC]

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Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Trimethadione (Tridione) which is also known as Tridione and Manufactured by AbbVie Inc.. It is available in strength of 150 mg/1 per ml. Read more

Trimethadione (Tridione) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials.  Click to know price.     Read less

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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  • BECAUSE OF ITS POTENTIAL TO PRODUCE FETAL MALFORMATIONS AND SERIOUS SIDE EFFECTS, TRIDIONE (trimethadione) SHOULD ONLY BE UTILIZED WHEN OTHER LESS TOXIC DRUGS HAVE BEEN FOUND INEFFECTIVE IN CONTROLLING PETIT MAL SEIZURES.
  • TRIDIONE (trimethadione) is an antiepileptic agent. An oxazolidinedione compound, it is chemically identified as 3,5,5-trimethyloxozolidine-2,4-dione, and has the following structural formula:
  • TRIDIONE is a synthetic, water-soluble, white, crystalline powder. It is supplied in tablets for oral use only.
  • TRIDIONE has been shown to prevent pentylenetetrazol-induced and thujone-induced seizures in experimental animals; the drug has a less marked effect on seizures induced by picrotoxin, procaine, cocaine, or strychnine. Unlike the hydantoins and antiepileptic barbiturates, TRIDIONE does not modify the maximal seizure pattern in patients undergoing electroconvulsive therapy.
  • TRIDIONE has a sedative effect that may increase to the point of ataxia when excessive doses are used. A toxic dose of the drug in animals (approximately 2 g/kg) produced sleep, unconsciousness, and respiratory depression.
  • Trimethadione is rapidly absorbed from the gastrointestinal tract. It is demethylated by liver microsomes to the active metabolite, dimethadione.
  • Approximately 3% of a daily dose of TRIDIONE is recovered in the urine as unchanged drug. The majority of trimethadione is excreted slowly by the kidney in the form of dimethadione.
  • TRIDIONE (trimethadione) is indicated for the control of petit mal seizures that are refractory to treatment with other drugs.
  • TRIDIONE is contraindicated in patients with a known hypersensitivity to the drug.
  • TRIDIONE may cause serious side effects. Strict medical supervision of the patient is mandatory, especially during the initial year of therapy.
  • Rash
  • TRIDIONE (trimethadione) should be withdrawn promptly if skin rash appears, because of the grave possibility of the occurrence of exfoliative dermatitis or severe forms of erythema multiforme. Even a minor acneiform or morbilliform rash should be allowed to clear completely before treatment with TRIDIONE is resumed; reinstitute therapy cautiously.
  • Blood Dyscrasias
  • A complete blood count should be done prior to initiating therapy with TRIDIONE, and at monthly intervals thereafter. A marked depression of the blood count is an indication for withdrawal of the drug. If no abnormality appears within 12 months, the interval between blood counts may be extended. A moderate degree of neutropenia with or without a corresponding drop in the leukocyte count is not uncommon. Therapy need not be withdrawn unless the neutrophil count is 2500 or less; more frequent blood examinations should be done when the count is less than 3,000. Other blood dyscrasias, including leukopenia, eosinophilia, thrombocytopenia, pancytopenia, agranulocytosis, hypoplastic anemia, and fatal aplastic anemia, have occurred. Patients should be advised to report immediately such signs and symptoms as sore throat, fever, malaise, easy bruising, petechiae, or epistaxis, or others that may be indicative of an infection or bleeding tendency. TRIDIONE should ordinarily not be used in patients with severe blood dyscrasias.
  • Liver Dysfunction
  • Liver function tests should be done prior to initiating therapy with TRIDIONE, and at monthly intervals thereafter. Hepatitis has been reported rarely. Jaundice or other signs of liver dysfunction are an indication for withdrawal of the drug. TRIDIONE should ordinarily not be used in patients with severe hepatic impairment.
  • Renal Dysfunction
  • A urinalysis should be done prior to initiating therapy with TRIDIONE and at monthly intervals thereafter. Fatal nephrosis has been reported. Persistent or increasing albuminuria, or the development of any other significant renal abnormality, is an indication for withdrawal of the drug. TRIDIONE should ordinarily not be used in patients with severe renal dysfunction.
  • Ocular Dysfunction
  • Hemeralopia has occurred; this appears to be an effect of TRIDIONE on the neural layers of the retina, and usually can be reversed by a reduction in dosage. Scotomata are an indication for withdrawal of the drug. Caution should be observed when treating patients who have diseases of the retina or optic nerve.
  • Lupus- and Myasthenia-like Syndromes
  • Manifestations of systemic lupus erythematosus have been associated with the use of TRIDIONE, as they have with the use of certain other anticonvulsants. Lymphadenopathies simulating malignant lymphoma have occurred. Lupus-like manifestations or lymph node enlargement are indications for withdrawal of the drug. Signs and symptoms may disappear after discontinuation of therapy, and specific treatment may be unnecessary.
  • A myasthenia gravis-like syndrome has been associated with the chronic use of trimethadione. Symptoms suggestive of this condition are indications for withdrawal of the drug.
  • Drugs known to cause toxic effects similar to those of TRIDIONE should be avoided or used only with extreme caution during therapy with TRIDIONE.
  • Abrupt discontinuation of TRIDIONE may precipitate petit mal status. TRIDIONE should always be withdrawn gradually unless serious adverse effects dictate otherwise. In the latter case, another anticonvulsant may be substituted to protect the patient.
  • The following side effects, some of them serious, have been associated with the use of TRIDIONE (trimethadione).
  • Symptoms of acute TRIDIONE overdosage include drowsiness, nausea, dizziness, ataxia, visual disturbances. Coma may follow massive overdosage.
  • Gastric evacuation, either by induced emesis, or by lavage, or both, should be done immediately. General supportive care, including frequent monitoring of the vital signs and close observations of the patient, are required.
  • Alkalinization of the urine has been reported to enhance the renal excretion of dimethadione, the active metabolite of TRIDIONE.
  • A blood count and a careful evaluation of hepatic and renal function should be done following recovery.
  • TRIDIONE is administered orally.
  • TRIDIONE Dulcet Tablets (trimethadione tablets) are supplied as white, chewable tablets bearing the u201cau201d logo and a two-letter code designation LE for the 150u00a0mg tablet, in bottles of 100 ( 0074-3753-01).
  • MEDICATION GUIDE
  • TRIDIONE
  • (trimethadione)
  • Tablets
  • Read this Medication Guide before you start taking TRIDIONE and each time you get a refill. There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or treatment.
  • What is the most important information I should know about TRIDIONE?
  • Do not stop taking TRIDIONE without first talking to your healthcare provider.
  • Stopping TRIDIONE suddenly can cause serious problems.
  • TRIDIONE can cause serious side effects, including:
  • What is TRIDIONE?
  • TRIDIONE is a prescription medicine used to treat absence (petit mal) seizures that are not controlled with other drugs.
  • Who should not take TRIDIONE?
  • Do not take TRIDIONE if you are allergic to trimethadione or any of the ingredients in TRIDIONE. See the end of this leaflet for a complete list of ingredients in TRIDIONE.
  • What should I tell my healthcare provider before taking TRIDIONE?
  • Before you take TRIDIONE, tell your healthcare provider if you have or have had:
  • Tell your healthcare provider about all the medicines you take,
  • How should I take TRIDIONE?
  • What should I avoid while taking TRIDIONE?
  • What are the possible side effects of TRIDIONE?
  • See u201cWhat is the most important information I should know about TRIDIONE?u201d
  • TRIDIONE may cause other serious side effects, including:
  • These are not all the possible side effects of TRIDIONE. For more information, ask your healthcare provider or pharmacist.
  • Tell your healthcare provider if you have any side effect that bothers you or that does not go away.
  • Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
  • How should I store TRIDIONE?
  • Keep TRIDIONE and all medicines out of the reach of children.
  • General Information about TRIDIONE
  • Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use TRIDIONE for a condition for which it was not prescribed. Do not give TRIDIONE to other people, even if they have the same symptoms that you have. It may harm them.
  • This Medication Guide summarizes the most important information about TRIDIONE. If you would like more information, talk with your healthcare provider. You can ask your pharmacist or healthcare provider for information about TRIDIONE that is written for health professionals. For more information, go to www.rxabbvie.com or call 1-800-633-9110.
  • What are the ingredients in TRIDIONE?
  • Active ingredient: trimethadione
  • Inactive ingredient: corn starch, lactose, magnesium stearate, magnesium trisilicate, sucrose and natural/synthetic flavor
  • Dulcet sweetened tablets, AbbVie Inc.
  • AbbVie Inc.
  • North Chicago, IL 60064, U.S.A.
  • This Medication Guide has been approved by the U.S. Food and Drug Administration.
  • 03-A773 April, 2013
  • NDC 0074u20133753u201301
  • 100 Tablets Dulcetn
  • TRIDIONEn
  • TRIMETHADIONE TABLETS 150 mg (2 1/2 grs)
  • Rx only abbvie

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