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Xenon (Xenon, Xe-133)

Trade Name : Xenon, Xe-133

Curium US LLC

GAS

Strength 5 mCi/mL

XENON XE-133 Inhalation Diagnostic Agent [EPC],Radiopharmaceutical Activity [MoA]

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Trade Marks displayed in compliance with provisions of: Trademark Act, 1999 u/s 30 and 30 (1) of "Fair use"

GNH India is WHO GDP and ISO 9001 2015 Certified Pharmaceutical Wholesaler/ Supplier/ Exporters/ Importer from India of Xenon (Xenon, Xe-133) which is also known as Xenon, Xe-133 and Manufactured by Curium US LLC. It is available in strength of 5 mCi/mL per ml. Read more

Xenon (Xenon, Xe-133) is supplied for Tenders/ Emergency imports/ Un - licensed, Specials, Orphan drug/ Name patient line/ RLD supplies/ Reference listed drugs/ Comparator Drug/ Bio-Similar/ Innovator samples For Clinical trials.  Click to know price.     Read less

Packaging and Delivery

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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About GNH

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

We deliver your medicines through a validated cold chain shipment process. This process is used as these medicines need to manufactured, transported and stored at very specific temperatures, utilizing thermal and refrigerated packaging methods.

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  • No data
  • Xenon Xe 133 Gas is for diagnostic inhalation use only. It is supplied in vials containing either 370 or 740 megabecquerels (10 or 20 millicuries) of Xenon Xe 133 Gas inu00a02 milliliters of carrier xenon and atmospheric air.
  • Xenon Xe 133 Gas is chemically and physiologically similar to elemental xenon, a non-radioactive gas which is physiologically inert except for anesthetic properties at high doses.
  • Xenon Xe 133 is produced by fission of Uranium U 235. At the time of calibration, it contains no more than 0.3% Xenon Xe 133m, no more than 1.5% Xenon Xe 131m, no more than 0.06% Krypton Kr 85 and no more than 0.01% Iodine I 131, with no less than 99.9% total radioactivity as radioxenon. Table 1 shows the effect of time on radionuclidic composition.
  • Table 1. Radionuclidic Composition
  • u00a0Xenon Xe 133 decays by beta and gamma emissions with a physical half-life of 5.245 days.u00a0Photons that are useful for detection and imaging studies as well as the principal beta emission are listed in Table 2.
  • Table 2. Principal Radiation Emission Data
  • The specific gamma ray constant for Xenon Xe 133 is 0.51 R/hr-mCi at 1 cm. The first half-value thickness is 0.0035 cm of Pb.
  • A range of values for the relative attenuation of the radiation emitted by this radionuclide that results from interposition of various thicknesses of Pb is shown in Table 3. For example, the use of 0.2 cm of Pb will decrease the external radiation exposure by a factor of about 1000.
  • Table 3. Radiation Attenuation by Lead Shielding
  • To correct for physical decay of this radionuclide, the fractions that remain at selected time intervals after the date of calibration are shown in Table 4.
  • Table 4. Physical Decay Chart; Xenon Xe 133, Half-life 5.245 Days
  • Xenon Xe 133 is a readily diffusible gas which is neither utilized nor produced by the body. It passes through cell membranes, freely exchanges between blood and tissue, and tends to concentrate more in body fat than in blood, plasma, water or protein solutions. In the concentrations recommended for diagnostic studies, it is physiologically inactive. Inhaled Xenon Xe 133 Gas will enter the alveolar wall and the pulmonary venous circulation via capillaries. Most of the Xenon Xe 133 Gas that enters the circulation from a single breath is returned to the lungs and exhaled after a single pass through the peripheral circulation.
  • Xenon Xe 133 Gas has been shown to be valuable for diagnostic inhalation studies for the evaluation of pulmonary function, for imaging the lungs and may also be applied to assessment of cerebral blood flow.
  • None known.
  • Xenon Xe 133 Gas delivery systems, i.e., respirators or spirometers, and associated tubing assemblies must be leakproof to avoid loss of radioactivity into the laboratory environs not specifically protected by exhaust systems.
  • Xenon Xe 133 Gas adheres to some plastics and rubber and should not be allowed to stand in tubing or respirator containers. Loss of radioactivity due to such adherence may render the study nondiagnostic.
  • No data
  • Adverse reactions specifically attributable to Xenon Xe 133 Gas have not been reported.
  • Xenon Xe 133 Gas is administered by inhalation from a closed respirator system or spirometer. The final patient dose should be measured by a suitable radioactivity calibration system immediately prior to administration.
  • The recommended activity range employed for inhalation by the average patient (70 kg) is:
  • Pulmonary function including imaging: 74 to 1110 megabecquerels (2 tou00a030 millicuries)
  • Cerebral blood flow: 370 to 1110 megabecquerels (10 to 30 millicuries)
  • This may be administered as a bolus into the tubing near the patient's mouthpiece or mask after the completion of a tidal exhalation, or by rebreathing for a period of approximately 5 minutes of the Xenon Xe 133 gas in equilibrium with the air contained in the closed system at concentrations of the radionuclide that may vary from 37 tou00a0222 megabecquerels (1.0 to 6.0 millicuries) per liter.
  • The estimated absorbed radiation doses to an average patient (70 kg) for inhalation studies from a maximum dose of Xenon Xe 133 gas in 5, 7.5 and 10 liters are shown in Table 5. The values are the maximum absorbed dose that could be anticipated under the given conditions.
  • Table 5. Radiation Dose Estimates of Xenon Xe 133: Absorbed Dose per 1110 megabecquerels (30 millicuries) of Xenon Xe 133 Gas Administered by Inhalation
  • Transfer the appropriate Xenon Xe 133 Gas dose from the Xenon Xe 133 Gas unit dose vial(s) to a breathing device or spirometer utilizing the Xenotronu2122 I Xenon Gas Dispenser.u00a0 Follow the directions for use that are provided with the Xenotronu2122 I Xenon Gas Dispenser.
  • Xenon Xe 133 Gas should not be used after 14 days from the date of calibration stated on the label.
  • Calibrate a suitable commercial ionization chamber dose calibrator according to the manufacturer's instructions for that particular instrument. An instrument that gives direct radioactivity readouts is recommended.
  • Use a National Institute of Standards and Technology (NIST) Xenon Xe 133 standard for the initial calibration. Also establish a secondary standard, such as Americiumu00a0Am 241, at that time for subsequent routine use. Other suitable radionuclides may also be used. Determine the effective readout of the secondary standard compared to the Xenon Xe 133 standard over the range of activities expected for routine measurements. Determine the radioactivities of the dose for administration as follows:
  • The radioactivity determined by this method is within 25% of the true value. This degree of accuracy includes variations attributed to small differences in geometry and radiation attenuation between the NIST standard ampule and the Xenon Xe 133 Gas unit dose vial.
  • Xenon Xe 133 Gas is available in 2 milliliter vials with color-coded labels inu00a0370 megabecquerel (10 millicurie; Catalog No. 097) and 740 megabecquerelu00a0(20 millicurie; Catalog No. 098) sizes. Both sizes are available in packages of 1, 3 and 5 vials, each with individual lead shielding.
  • Xenon Xe 133 Gas should be stored at controlled room temperature 20u00b0 to 25u00b0Cu00a0(68u00b0 to 77u00b0F). [See USP Controlled Room Temperature.]
  • The U.S. Nuclear Regulatory Commission has approved distribution of this radiopharmaceutical to persons licensed to use byproduct material listed in Sections 35.200 and to persons who hold an equivalent license issued by an Agreement State.
  • Curium and the Curium logo are trademarks of a Curium company.u00a92018 Curium US LLC. All Rights Reserved.n
  • Curium USu00a0LLCMaryland Heights, MO 63043 USA
  • A097I0
  • R12/2018
  • CURIUMu2122
  • XENON Xe 133 GAS
  • 370 MBq (10 mCi)/vial
  • CAUTION RADIOACTIVE MATERIAL
  • Single Dose Container -Dispose in Accordance with Regulatory Requirements. For use with Xenotronu2122 I Xenon Gas Dispenser only.
  • Rx only
  • Curium USu00a0LLC
  • A097V0
  • R03/2019
  • XENON Xe 133 GAS
  • 740 MBq (20 mCi)/vial
  • CAUTION RADIOACTIVE MATERIAL
  • Single Dose Container -Dispose in Accordance with Regulatory Requirements. For use with Xenotronu2122 I Xenon Gas Dispenser only.
  • Rx only
  • Arrayn- Curium USu00a0LLC
  • A098V0
  • R03/2019

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