Product image of Manidón (Verapamil Hydrochloride) supplied by GNH India

Manidón

Active Ingredient:
Verapamil Hydrochloride
Origin:
EU

Manidón (Verapamil Hydrochloride)

Verapamil, the active ingredient in Manidón, is a calcium channel blocker presented as a tablet (strength not specified) for oral use. It treats hypertension, angina pectoris and certain supraventricular tachyarrhythmias in adult patients.

GNH India supplies Manidón as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Mylan Ire Healthcare Limited

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Indications & Clinical Uses

  • Verapamil is a calcium channel blocker used in cardiovascular conditions.
  • Hypertension: lowers blood pressure by reducing peripheral vascular resistance.
  • Angina pectoris: relieves chest pain by decreasing myocardial oxygen demand.
  • Supraventricular tachyarrhythmias: controls heart rate by slowing conduction through the atrioventricular node.

How It Works

  • Verapamil blocks L-type calcium channels in cardiac and vascular smooth muscle, reducing calcium influx. This leads to decreased myocardial contractility, vasodilation of peripheral arteries, and slowed conduction through the atrioventricular node, thereby lowering blood pressure, reducing cardiac workload, and controlling abnormal heart rhythms.

Side Effects

Common side effects are generally mild and may resolve with continued therapy.

Common Side Effects

  • Headache: mild to moderate head pain.
  • Dizziness: sensation of light‑headedness.
  • Constipation: reduced bowel motility.
  • Peripheral edema: swelling of the ankles or lower legs.

Serious or Rare Side Effects

  • Severe hypotension: marked drop in blood pressure.
  • Bradycardia: abnormally slow heart rate.
  • Atrioventricular block: impaired electrical conduction between atria and ventricles.

Precautions & Warnings

  • Before initiating verapamil therapy, consider the following precautions.
  • Cardiovascular assessment: evaluate blood pressure and heart rate prior to treatment.
  • Concomitant beta‑blockers: monitor for excessive bradycardia.
  • Liver impairment: use with caution; dose may need adjustment.
  • Renal impairment: monitor drug levels in severe dysfunction.
  • Pregnancy and lactation: avoid unless benefits outweigh risks.
  • Store at ambient temperature: keep below 25°C in the original container, protect from moisture.

Avoid Interactions

Verapamil may interact with several medicines; awareness of the interaction level is essential.

Major Interactions (Avoid)

  • Strong CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin): can markedly increase verapamil plasma concentrations.
  • Digoxin: concurrent use may raise digoxin levels and risk toxicity.

Moderate Interactions (Monitor Closely)

  • Beta‑blockers: combined effect may cause excessive bradycardia or AV block.
  • Diuretics: may enhance hypotensive effect.
  • Antacids containing aluminum or magnesium: may reduce absorption of verapamil.

Frequently Asked Questions

Manidón contains verapamil, which is prescribed for hypertension, angina pectoris, and certain supraventricular tachyarrhythmias. It helps lower high blood pressure, relieve chest pain caused by reduced heart blood flow, and control abnormal rapid heart rhythms.

Verapamil blocks L-type calcium channels in cardiac and vascular smooth muscle. By reducing calcium entry, it relaxes blood vessels, decreases the force of heart muscle contraction, and slows electrical conduction through the atrioventricular node, leading to lower blood pressure and controlled heart rate.

The appropriate dose of Manidón is determined by the prescribing healthcare professional based on the individual’s medical condition, response to therapy, and other factors. Patients should follow the prescriber’s instructions and not adjust the dose on their own.

Verapamil should only be used during pregnancy or lactation if the potential benefit justifies the potential risk to the fetus or infant. Healthcare providers will evaluate the risk‑benefit profile before prescribing it to pregnant or nursing women.

To order Manidón, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details and any required import documentation.

Manidón (verapamil) belongs to the calcium channel blocker class, which reduces blood pressure by relaxing vascular smooth muscle. Compared with beta‑blockers or ACE inhibitors, verapamil also slows heart rate and AV‑node conduction, making it useful for patients who need both blood‑pressure control and heart‑rate reduction.

Manidón should be stored at ambient temperature, preferably below 25 °C. Keep the tablets in the original packaging, protect them from moisture and direct sunlight, and ensure the container is tightly closed to maintain product stability.

Manidón is taken orally, usually with a glass of water. It can be taken with or without food, but consistency with meals may help reduce gastrointestinal discomfort. Patients should follow the dosing schedule prescribed by their healthcare provider.

Serious risks include severe hypotension, marked bradycardia, and atrioventricular block, which can lead to fainting or cardiac complications. Patients should report symptoms such as dizziness, fainting, unusually slow heartbeat, or chest discomfort to their physician promptly.

Manidón is contraindicated in patients with known hypersensitivity to verapamil or other calcium channel blockers, those with severe sinus bradycardia, advanced atrioventricular block without a pacemaker, and in certain cases of acute myocardial infarction. A healthcare professional should evaluate suitability before prescribing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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