Product image of Votrient 400mg (Pazopanib) 400mg Tablet supplied by GNH India

Votrient 400mg

Active Ingredient:
Pazopanib
Form:
Tablet
Brand:
Votrient
Origin:
UK

Votrient 400mg (Pazopanib Tablet) 400mg

Pazopanib, the active ingredient in Votrient 400mg, is a tyrosine kinase inhibitor presented as a 400mg tablet for oral use. It is used to treat advanced renal cell carcinoma and certain types of soft tissue sarcoma. GNH India supplies Votrient 400mg as a licensed, GDP-compliant international pharmaceutical supplier serving oncology centres worldwide.

Votrient 400mg is a prescription-only medication that requires careful monitoring and administration under the guidance of a healthcare professional. It is part of a class of drugs known as antineoplastics, which are used to inhibit the growth and spread of cancer cells.

Strength

400mg

Pack Size

30s

Storage

Ambient

Manufacturer / TM Owner

Glaxo Operations UK LTD

1
Pack/s
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Indications & Clinical Uses

Votrient 400mg is used to treat specific types of cancer by inhibiting the growth and spread of cancer cells.

  • Renal cell carcinoma: Used to treat advanced kidney cancer that may have spread to other parts of the body.
  • Soft tissue sarcoma: Used to treat advanced soft tissue sarcoma, which affects the supporting tissues such as muscles, fat cells, and blood vessels.

How It Works

  • Votrient 400mg works by inhibiting multiple receptor tyrosine kinases, including VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-α/β, and c-Kit. This inhibition leads to anti-angiogenic and anti-tumor effects, reducing the blood supply to tumors and slowing their growth.

Side Effects

Votrient 400mg can cause various side effects, ranging from common to serious.

Common Side Effects

  • Nausea and vomiting
  • Diarrhea
  • Fatigue
  • High blood pressure
  • Loss of appetite
  • Hair color changes

Serious or Rare Side Effects

  • Liver damage
  • Heart problems
  • Bleeding or hemorrhage
  • Perforation or fistula formation
  • Severe skin reactions

Precautions & Warnings

Votrient 400mg should be used with caution and under the supervision of a healthcare professional.

  • Liver function: Regular monitoring of liver function is required due to the risk of liver damage.
  • Heart function: Patients with heart conditions should be monitored closely.
  • Bleeding risk: Use with caution in patients with a history of bleeding disorders.
  • Pregnancy: Should be avoided during pregnancy due to potential harm to the fetus.
  • Breastfeeding: Should be avoided during breastfeeding.
  • Store below 25°C: Keep in the original pack, protect from moisture.

Avoid Interactions

Votrient 400mg can interact with other medications, which may affect its efficacy or increase the risk of side effects.

Major Interactions (Avoid)

  • Strong CYP3A4 inducers: Can decrease the effectiveness of Votrient 400mg.
  • Strong CYP3A4 inhibitors: Can increase the risk of side effects.

Moderate Interactions (Monitor Closely)

  • Anticoagulants: Increased risk of bleeding.
  • Antihypertensives: May need dose adjustment due to changes in blood pressure.
  • Drugs metabolized by CYP3A4: May require dose adjustment.

Frequently Asked Questions

Votrient 400mg is used to treat advanced renal cell carcinoma and certain types of soft tissue sarcoma. It works by inhibiting the growth and spread of cancer cells, making it an effective treatment for these types of cancer.

Pazopanib, the active ingredient in Votrient 400mg, works by inhibiting multiple receptor tyrosine kinases. This includes VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-α/β, and c-Kit. By inhibiting these kinases, Pazopanib reduces the blood supply to tumors and slows their growth, leading to anti-angiogenic and anti-tumor effects.

The usual dose of Votrient 400mg is determined by a healthcare professional based on the patient's condition and response to treatment. It is typically taken once daily on an empty stomach, either one hour before or two hours after a meal.

Votrient 400mg should be avoided during pregnancy as it can cause harm to the fetus. It is also advised to avoid breastfeeding while taking this medication due to potential risks to the infant. Always consult a healthcare professional for personalized advice.

To order Votrient 400mg from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets. The team will ask you to confirm your trade or institutional credentials and will reply with pricing, availability, shipping, and the necessary import paperwork.

Votrient 400mg is a tyrosine kinase inhibitor specifically used for renal cell carcinoma and soft tissue sarcoma. Compared to other cancer treatments, it offers a targeted approach by inhibiting specific pathways involved in tumor growth and angiogenesis. The choice of treatment depends on the type and stage of cancer, as well as the patient's overall health.

Votrient 400mg should be stored below 25°C, kept in the original pack, and protected from moisture. It is important to follow the storage instructions provided to maintain the medication's effectiveness and safety.

Votrient 400mg is administered orally as a tablet. It should be taken once daily on an empty stomach, either one hour before or two hours after a meal. The tablets should be swallowed whole with a glass of water and not crushed, broken, or chewed.

The most serious risks associated with Votrient 400mg include liver damage, heart problems, bleeding or hemorrhage, perforation or fistula formation, and severe skin reactions. Regular monitoring and close supervision by a healthcare professional are essential to manage these risks.

Votrient 400mg should not be used by individuals with severe liver or heart conditions, those who are pregnant or breastfeeding, and those with a known hypersensitivity to Pazopanib or any of the excipients in the medication. Always consult a healthcare professional for personalized advice.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

References

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