Product image of Xeljanz (Tofacitinib) supplied by GNH India

Xeljanz

Active Ingredient:
Tofacitinib
Origin:
EU

Xeljanz (Tofacitinib)

Xeljanz (tofacitinib) is an oral medication used for inflammatory conditions. It belongs to the JAK inhibitor class and is prescribed for adults with moderate to severe rheumatoid arthritis, psoriatic arthritis, or ulcerative colitis when other treatments are ineffective. Always consult a healthcare professional for suitability.

Manufacturer / TM Owner

Pfizer Europe Ma Eeig

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Indications & Clinical Uses

  • Tofacitinib is primarily used to reduce inflammation and immune system activity in adults with rheumatoid arthritis, psoriatic arthritis, or ulcerative colitis. It may be prescribed when conventional therapies like methotrexate or biologics have not provided sufficient relief. The medication works by targeting specific pathways in the immune system to help manage symptoms such as joint pain, swelling, and digestive discomfort. It is not a cure but can help control disease progression.

Side Effects

  • Common effects of tofacitinib include mild to moderate gastrointestinal discomfort, such as nausea or diarrhea, especially when first starting the medication. Some users may experience mild headaches or upper respiratory infections. These effects are typically temporary and may lessen as the body adjusts to the treatment. Regular monitoring by a healthcare provider is recommended to assess how the medication is working.

Precautions & Warnings

  • Tofacitinib should be taken exactly as prescribed, and patients should inform their doctor of any existing infections, liver problems, or blood disorders before starting treatment. It is important to avoid live vaccines while on this medication and to report any signs of infection, such as fever or persistent cough, immediately. Alcohol use should be limited, as it may increase the risk of side effects. Pregnant or breastfeeding individuals should discuss risks with their healthcare provider.

Avoid Interactions

  • Tofacitinib may interact with other medications that affect the immune system, such as corticosteroids or certain biologics, potentially increasing the risk of infections. Strong CYP3A4 inhibitors (e.g., ketoconazole) or inducers (e.g., rifampin) can alter tofacitinib levels in the blood, requiring dose adjustments. Combining it with live vaccines is not recommended. Always inform your doctor about all prescription, over-the-counter, and herbal products you are using.

Frequently Asked Questions

Xeljanz (tofacitinib) is used to treat adults with moderate to severe rheumatoid arthritis, psoriatic arthritis, or ulcerative colitis when other treatments have not worked.

Xeljanz is taken orally as directed by a healthcare provider, usually twice daily with or without food. Follow your doctor’s instructions carefully.

Common side effects include nausea, diarrhea, headaches, and mild infections like the common cold. Serious infections or liver problems are rare but possible.

Alcohol should be limited while taking Xeljanz, as it may increase the risk of side effects. Discuss your alcohol consumption with your doctor.

The safety of Xeljanz during pregnancy has not been fully established. Discuss potential risks and benefits with your healthcare provider before use.

Published by

GNH India Pharmaceuticals Limited

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Last updated:

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