Product image of Xeloda 500mg (Capecitabine ) 500mg Tablet supplied by GNH India

Xeloda 500mg

Active Ingredient:
Capecitabine
Form:
Tablet
Brand:
Xeloda
Origin:
India

Xeloda 500mg (Capecitabine Tablet) 500mg

Capecitabine, the active ingredient in Xeloda 500mg, is an antimetabolite presented as a 500mg tablet for oral use. It is used to treat various types of cancer, including metastatic colorectal cancer, adjuvant treatment of colon cancer, metastatic breast cancer, and gastric cancer. GNH India supplies Xeloda 500mg as a licensed, GDP-compliant international pharmaceutical supplier serving oncology centres worldwide.

GNH India is a trusted supplier of high-quality pharmaceuticals, ensuring that Xeloda 500mg meets international standards for safety and efficacy.

Strength

500mg

Pack Size

120s

Storage

Ambient

Manufacturer / TM Owner

Roche Products India Pvt.Ltd.

1
Pack/s
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Indications & Clinical Uses

Xeloda 500mg is an antineoplastic agent used in the treatment of various cancers. It is indicated for the following conditions:

  • Metastatic colorectal cancer: Used to treat cancer that has spread to other parts of the body.
  • Adjuvant treatment of colon cancer: Used after surgery to reduce the risk of cancer recurrence.
  • Metastatic breast cancer: Used to treat breast cancer that has spread to other parts of the body.
  • Gastric cancer: Used in combination with other treatments to manage stomach cancer.

How It Works

  • Capecitabine, the active ingredient in Xeloda 500mg, is a prodrug that is metabolized to 5-fluorouracil. It inhibits thymidylate synthase, which interferes with DNA synthesis in rapidly dividing tumor cells, thereby slowing or stopping the growth of cancer cells.

Side Effects

Xeloda 500mg may cause various side effects, ranging from common to serious or rare. Common Side Effects:

  • Diarrhea
  • Nausea
  • Anemia
  • Lymphopenia
  • Hand and foot syndrome
  • Fatigue
  • Vomiting
  • Stomatitis

Serious or Rare Side Effects

  • Cardiotoxicity
  • Bone marrow suppression
  • Severe diarrhea
  • Severe stomatitis
  • Neutropenia
  • Thrombocytopenia
  • Dehydration

Precautions & Warnings

Xeloda 500mg should be used with caution and under the supervision of a healthcare professional. Important precautions include:

  • Hepatic dysfunction: Monitor liver function regularly.
  • Bone marrow suppression: Regularly monitor blood counts.
  • Poor nutritional status: Ensure adequate nutrition during treatment.
  • Warfarin therapy: Monitor coagulation parameters closely.
  • Renal impairment: Adjust dosage as necessary.
  • Pregnancy: Avoid use during pregnancy due to potential harm to the fetus.
  • Store below 25°C: Keep in the original pack, protect from moisture.

Avoid Interactions

Xeloda 500mg may interact with other medications, potentially affecting its efficacy or increasing the risk of side effects. Major Interactions (Avoid):

  • Brivudine or sorivudine: Avoid concurrent use due to increased risk of severe adverse reactions.
  • Dihydropyrimidine dehydrogenase (DPD) deficiency: Avoid use in patients with this condition.

Moderate Interactions (Monitor Closely)

  • Warfarin: Monitor coagulation parameters closely.
  • Phenytoin: Monitor for signs of toxicity.
  • Allopurinol: Monitor for increased side effects.

Frequently Asked Questions

Xeloda 500mg is used to treat various types of cancer, including metastatic colorectal cancer, adjuvant treatment of colon cancer, metastatic breast cancer, and gastric cancer. It is an antineoplastic agent that helps to slow or stop the growth of cancer cells.

Capecitabine, the active ingredient in Xeloda 500mg, is a prodrug that is metabolized to 5-fluorouracil. It inhibits thymidylate synthase, which interferes with DNA synthesis in rapidly dividing tumor cells, thereby slowing or stopping the growth of cancer cells.

The usual dose of Xeloda 500mg is determined by a healthcare professional based on the patient's body surface area and the specific condition being treated. It is typically taken orally twice daily for two weeks, followed by a one-week rest period.

Xeloda 500mg is not recommended during pregnancy as it can harm the fetus. It is also not recommended during breastfeeding due to the potential risks to the infant. Always consult a healthcare professional for personalized advice.

To order Xeloda 500mg from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets and will ask the buyer to confirm trade or institutional credentials. The team will then provide pricing, availability, shipping, and the necessary import paperwork.

Xeloda 500mg is an oral chemotherapy agent that offers convenience for patients who prefer not to receive intravenous treatments. It is effective in treating specific types of cancer and is often used in combination with other therapies. The choice of treatment depends on the type and stage of cancer, as well as the patient's overall health.

Xeloda 500mg should be stored below 25°C, kept in the original pack, and protected from moisture. It should be handled with care, and any broken or damaged tablets should be disposed of properly. Always follow the storage instructions provided by the manufacturer.

Xeloda 500mg is taken orally, typically twice daily for two weeks, followed by a one-week rest period. The tablets should be swallowed whole with water within 30 minutes after the end of a meal. Do not crush, chew, or cut the tablets.

The most serious risks associated with Xeloda 500mg include cardiotoxicity, bone marrow suppression, severe diarrhea, severe stomatitis, neutropenia, and thrombocytopenia. Patients should be monitored closely for these side effects, and any severe reactions should be reported to a healthcare professional immediately.

Xeloda 500mg should not be taken by individuals who are allergic to capecitabine, 5-fluorouracil, or any ingredients of the medication. It should also be avoided by patients with dihydropyrimidine dehydrogenase (DPD) deficiency, severely reduced kidney function, or those being treated with brivudine or sorivudine.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

References

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