Xermelo (Telotristat Ethyl Tablet) 250mg

XERMELO (telotristat ethyl) 250mg tablets are indicated as adjunctive therapy for carcinoid syndrome diarrhea. This prescription medication helps manage symptoms when used alongside somatostatin analog therapy. Telotristat ethyl is designed to reduce excess serotonin production linked to carcinoid tumors. Available in 84-tablet bottles for convenient dispensing.

Strength

250mg

Pack Size

84s

Storage

Ambient

Manufacturer / TM Owner

TerSera Therapeutics LLC

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Pack/s

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Indications & Clinical Uses

XERMELO (telotristat ethyl) is primarily used to treat diarrhea associated with carcinoid syndrome, a condition that occurs when carcinoid tumors release excess serotonin into the bloodstream. It is prescribed alongside somatostatin analog therapy for patients who experience inadequate symptom control. This medication helps reduce the frequency of bowel movements in adults with metastatic neuroendocrine tumors. It is not intended for general diarrhea unrelated to carcinoid syndrome.

Side Effects

XERMELO (telotristat ethyl) works by inhibiting tryptophan hydroxylase, an enzyme involved in serotonin production. Patients may notice a reduction in the number of daily bowel movements over time. Some individuals report improved comfort and fewer urgent bathroom trips. The effects are typically observed within a few weeks of consistent use. Individual responses may vary based on the underlying condition.

Precautions & Warnings

XERMELO (telotristat ethyl) should be stored at room temperature in a dry place away from moisture and heat. Keep the medication in its original container with the lid tightly closed to maintain potency. Always check the expiration date before use and dispose of unused tablets properly. Patients should follow their healthcare provider’s instructions for handling and storage.

Avoid Interactions

XERMELO (telotristat ethyl) may interact with medications that affect liver enzymes, such as certain antidepressants or antifungal agents. Combining it with strong CYP3A4 inhibitors could alter its effectiveness or side effects. Patients taking other drugs for diarrhea or serotonin-related conditions should inform their doctor. Alcohol use may exacerbate side effects like nausea or dizziness.

Frequently Asked Questions

XERMELO is used to treat diarrhea associated with carcinoid syndrome in adults when somatostatin analog therapy is insufficient.

Some patients notice improvements within a few weeks, but individual results may vary based on the condition and treatment plan.

XERMELO can be taken with or without food, but it should be swallowed whole with water.

Common side effects may include nausea, headache, or abdominal pain. Consult a healthcare provider if symptoms persist.

No, XERMELO is not a controlled substance but requires a prescription for dispensing.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated: 29 Jul 2026

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