Xiaflex - Collagenase Clostridium Histolyticum

Storage/Handling:

Store at room temperature away from light and moisture.

Uses of Xiaflex - Collagenase Clostridium Histolyticum:

Used in the treatment of -
Dupuytren’s contracture
Peyronie’s disease

Product Introduction:

XIAFLEX® (collagenase clostridium histolyticum) is a prescription medication used to treat Dupuytren's contracture and Peyronie's disease. It works by breaking down collagen in thickened tissues, helping to alleviate symptoms such as finger contracture in Dupuytren's contracture or penile curvature in Peyronie's disease

For Peyronie's disease, it's mentioned that XIAFLEX® is available only from a certified pharmacy under a special program called Xiaflex REMS (Risk Evaluation and Mitigation Strategy). This program likely involves specific protocols to ensure the safe and appropriate use of the medication due to potential risks associated with its use.

Patients interested in using XIAFLEX® for Peyronie's disease need to be registered in the Xiaflex REMS program and must understand the risks associated with taking this medicine. This emphasizes the importance of medical supervision and careful consideration of potential side effects and risks associated with the medication.

It's crucial for individuals considering XIAFLEX® to consult with their healthcare provider to determine if the medication is appropriate for their specific condition and to ensure they meet the necessary requirements for participation in the Xiaflex REMS program.

Side Effects of Xiaflex - Collagenase Clostridium Histolyticum:

Common Cerdelga side effects may include -

• swelling, bruising, bleeding, pain, or tenderness where the medicine was injected

• swollen glands in your elbow or underarm;

• itching, redness, or warmth of the skin;

• cracked skin

• underarm pain

• pain or tenderness in your treated hand

• bruising of the penis or scrotum, erection problems

discoloration of the skin on your penis, bruising or blisters where the medicine was injected.

• Dupuytren’s contracture side effects -

• fever, chills, increased redness, or swelling;

• numbness, or tingling in the treated finger; or

trouble bending the injected finger after the swelling decreases.

• Peyronie’s disease side effects -

• bruising and swelling of your penis;

• pain when you urinate, blood in the urine;

• sudden erection problems; or

• a "popping" sound or sensation in your penis during an erection.

Drug Interactions:

The interaction of drugs has the potential to alter the effectiveness of your medications or elevate the risk of experiencing severe side effects. It's important to note that this document may not encompass all conceivable drug interactions. Maintain a comprehensive list of all the products you are using, which includes prescription/nonprescription drugs and herbal products, and share this information with both your doctor and pharmacist. Any modifications to the dosage or initiation and cessation of medicines should only be carried out with the approval of your doctor.

Certain products may have interactions with this drug, particularly those known to cause bleeding or bruising, such as aspirin, antiplatelet drugs like clopidogrel, NSAIDs like ibuprofen, and "blood thinners" like warfarin.

In specific cases, your doctor might advise you to discontinue these medications seven days before your injection. If such guidance is provided, it's essential to inquire about the safe timeframe to resume taking them.

How Xiaflex - Collagenase Clostridium Histolyticum Works:

XIAFLEX contains an enzyme called collagenase, which breaks down collagen, a protein that forms part of the thickened tissue in both Dupuytren's contracture and Peyronie's disease. By breaking down this collagen, XIAFLEX can help to loosen and straighten the affected areas.

Safety Instructions For Xiaflex - Collagenase Clostridium Histolyticum:

ALCOHOL (Caution) There’s no known interaction between alcohol and Xiaflex but if you have any questions contact your doctor for the same. PREGNANCY (Consult your doctor) It is not known if collagenase clostridium histolyticum will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. BREAST FEEDING (Consult your doctor) The information regarding the effect of xiaflex while breastfeeding the infant is not known yet it is advised to consult your doctor for the same. DRIVING (Caution) Avoid driving, operating machinery, or engaging in activities requiring alertness until you can do so safely. LIVER (Consult Your Doctor) No information is known yet inform your doctor of any liver disease.
KIDNEY (Consult Your Doctor)No information is known yet inform your doctor of any kidney disease.
CHILDREN (unsafe)Keep this medication out of the reach of children.

Habit Forming

No

Remember:

1. Although it does not provide a cure for Dupuytren's contracture or Peyronie's disease, it can alleviate symptoms; however, the conditions may reoccur post-treatment.
2. If you have any underlying medical conditions, particularly heart disease, liver disease, kidney disease, or diabetes, please inform your doctor.
3. Adhere closely to your healthcare professional's guidance on dosage, injection schedule, and post-treatment care.
4. Refrain from bending or straightening your treated hand following XIAFLEX® injection until advised by your doctor.
5. It may be necessary to wear a splint on your hand after the treatment.
6. Abstain from engaging in sexual activity for six weeks after each XIAFLEX® injection for Peyronie's disease.
7. Your penis may require bandaging for a brief period after each injection; follow your doctor's instructions regarding the duration of bandage use.

FAQs:

1. How is Xiaflex administered?

Xiaflex is administered by injecting it directly into the affected hand's "cord" or into the penis's "plaque." A healthcare provider will perform the injection, and it is crucial to carefully follow your doctor's instructions.

2. What should I do if I miss a dose of Xiaflex?

If you miss a dose, promptly inform your healthcare provider and follow their guidance on how to proceed.

3. What happens in case of a Xiaflex overdose?

In the event of an overdose, prompt medical attention in a healthcare setting is advised. It is essential to inform your doctor about the situation.

4. Are there any allergic reactions associated with Xiaflex?

If you experience signs of an allergic reaction to Xiaflex, such as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat, seek emergency medical help.

5. How is Xiaflex (collagenase) administered?

Xiaflex (collagenase) is administered through injection directly into scar tissue by a trained healthcare provider. For Dupuytren’s contracture, the injection is targeted at the cord of tissue in the hand, while for Peyronie's disease, it is aimed at the plaque causing the penile curvature.

6. What is the recovery time for Xiaflex (collagenase) injections for Peyronie's disease?

Recovery from Xiaflex injections for Peyronie's disease may take a few weeks. To facilitate healing, avoid activities that may harm the penis. Refrain from sexual activity between the first and second injections of a treatment cycle, and wait at least 4 weeks after the second injection before engaging in sexual activity. Contact your healthcare provider immediately if you experience severe pain, swelling, bruising of the penis, difficulty urinating, or blood in the urine after the injection, as these could indicate complications from the treatment.