Product image of Zemplar (Paricalcitol) supplied by GNH India

Zemplar

Active Ingredient:
Paricalcitol
Origin:
EU

Zemplar (Paricalcitol)

Paricalcitol is a vitamin D analog used to manage secondary hyperparathyroidism in chronic kidney disease. This oral medication helps regulate calcium levels for patients on dialysis or with stage 3-4 CKD. Commonly prescribed for parathyroid hormone control, it supports bone health and mineral balance.

Manufacturer / TM Owner

Abbvie Pharmaceuticals S.A.

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Indications & Clinical Uses

  • Paricalcitol is primarily used to treat secondary hyperparathyroidism in adults with chronic kidney disease. It works by reducing elevated parathyroid hormone levels, which can otherwise lead to bone and mineral disorders. The medication is often prescribed for patients undergoing dialysis or those with moderate to advanced CKD who require hormone regulation. It may also be used in cases where calcium and phosphorus imbalances need correction.

Side Effects

  • Paricalcitol helps maintain balanced parathyroid hormone levels, which supports overall bone health and mineral metabolism. Patients may notice improved calcium and phosphorus levels over time, contributing to better metabolic stability. The medication’s effects are typically gradual, with noticeable changes occurring after consistent use. Some individuals report reduced symptoms related to high parathyroid hormone levels, such as bone discomfort.

Precautions & Warnings

  • Paricalcitol should be taken exactly as prescribed by a healthcare provider to avoid fluctuations in calcium levels. Regular blood tests are recommended to monitor parathyroid hormone, calcium, and phosphorus levels during treatment. Patients with a history of hypercalcemia or vitamin D toxicity should use this medication with caution. It is important to follow dietary guidelines provided by a doctor to support the medication’s effectiveness.

Avoid Interactions

  • Certain medications, such as strong CYP3A4 inhibitors or inducers, may affect how paricalcitol is metabolized in the body. Cholestyramine and other bile acid sequestrants can reduce absorption, so they should be taken at different times. High doses of calcium or vitamin D supplements may increase the risk of hypercalcemia when combined with paricalcitol. Always inform a healthcare provider about all medications and supplements being taken.

Frequently Asked Questions

Paricalcitol is used to treat secondary hyperparathyroidism in adults with chronic kidney disease.

It should be taken orally as directed by a healthcare provider, usually with or without food.

Common side effects may include nausea, vomiting, or mild headache.

Yes, it can lead to hypercalcemia, which is why regular blood tests are recommended.

Long-term use should be monitored by a healthcare provider to ensure safety and effectiveness.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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