Product image of Lamivudină/Zidovudină Aurobindo (Zidovudine, Lamivudine) supplied by GNH India

Lamivudină/Zidovudină Aurobindo

Active Ingredient:
Zidovudine, Lamivudine
Origin:
EU

Lamivudină/Zidovudină Aurobindo (Zidovudine, Lamivudine)

Lamivudine and Zidovudine, the active ingredients in Lamivudină/Zidovudină Aurobindo, are nucleoside reverse transcriptase inhibitors presented as oral tablets for oral use. They treat HIV-1 infection in both adults and children as part of combination antiretroviral therapy.

GNH India supplies Lamivudină/Zidovudină Aurobindo as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals and pharmacies worldwide. The company adheres to stringent quality standards and provides reliable logistics for global distribution. Clients benefit from consistent product availability, regulatory compliance, and dedicated technical support throughout the supply chain.

Manufacturer / TM Owner

Aurobindo Pharma (Malta) Limited

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Indications & Clinical Uses

Lamivudină/Zidovudină is employed in antiretroviral therapy that targets HIV-1 replication.

  • HIV-1 infection in adults: reduces viral load and helps restore immune function.
  • HIV-1 infection in children: improves growth parameters and decreases opportunistic infections.
  • Treatment‑experienced HIV-1 infection: used as part of salvage regimens when resistance has developed.
  • Prevention of mother‑to‑child transmission: incorporated into combination prophylaxis to lower transmission risk during pregnancy and delivery.

How It Works

  • Lamivudină/Zidovudină combines two nucleoside analogues that are phosphorylated intracellularly to their active triphosphate forms. These active metabolites compete with natural nucleosides for incorporation into viral DNA by HIV reverse transcriptase, causing chain termination and halting viral DNA synthesis, thereby suppressing HIV replication.

Side Effects

Adverse reactions may vary in frequency and severity.

Common Side Effects

  • Nausea: mild to moderate gastrointestinal upset.
  • Headache: transient cranial discomfort.
  • Fatigue: generalised tiredness.
  • Anemia: reduced red blood cell count.
  • Neutropenia: lowered neutrophil levels.
  • Diarrhoea: loose stools.

Serious or Rare Side Effects

  • Severe liver toxicity: hepatic enzyme elevation or failure.
  • Lactic acidosis: accumulation of lactate leading to metabolic acidosis.
  • Severe neutropenia: risk of opportunistic infections.
  • Hypersensitivity reactions: rash, fever, or organ involvement.
  • Pancreatitis: inflammation of the pancreas.
  • Bone marrow suppression: pancytopenia affecting multiple cell lines.

Precautions & Warnings

Patients should be monitored for safety and efficacy before and during therapy.

  • Blood count monitoring: regularly assess haemoglobin and neutrophil levels.
  • Liver function assessment: evaluate hepatic enzymes prior to initiation.
  • Renal function evaluation: check creatinine clearance in patients with kidney disease.
  • Adherence counseling: emphasize the importance of consistent dosing.
  • Hypersensitivity avoidance: discontinue if severe allergic reactions occur.
  • Store at ambient temperature: keep in original packaging, protect from moisture and direct sunlight.

Avoid Interactions

Lamivudină/Zidovudină may interact with several concomitant medications.

Major Interactions (Avoid)

  • Didanosine: increased risk of peripheral neuropathy and pancreatitis.
  • Stavudine: heightened mitochondrial toxicity leading to lactic acidosis.
  • Alcohol: potentiates hepatotoxic effects.

Moderate Interactions (Monitor Closely)

  • Rifampin: induces metabolism, reducing drug concentrations.
  • Antacids containing aluminium or magnesium: may impair absorption.
  • Protease inhibitors (e.g., ritonavir): alter plasma levels, requiring dose adjustment.

Frequently Asked Questions

Lamivudină/Zidovudină is an oral antiretroviral medication indicated for the treatment of HIV-1 infection in both adults and children. It is used as part of combination therapy to suppress viral replication, improve immune function, and reduce the risk of disease progression.

Lamivudine is a nucleoside reverse transcriptase inhibitor that, after intracellular phosphorylation, mimics natural nucleosides. When incorporated into viral DNA by HIV reverse transcriptase, it causes chain termination, preventing further viral DNA synthesis and thereby inhibiting HIV replication.

The specific dosage regimen for Lamivudină/Zidovudină is determined by the prescribing clinician based on the patient’s age, weight, treatment history, and co‑administered drugs. Healthcare professionals tailor the dose to achieve optimal viral suppression while minimizing toxicity.

Safety data for lamivudine and zidovudine in pregnancy and lactation are limited. Clinicians should weigh the potential benefits of controlling maternal HIV infection against any possible risks to the fetus or infant. Treatment decisions are made on an individual basis, following current guidelines.

To request Lamivudină/Zidovudină, submit an enquiry on the product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Lamivudină/Zidovudină combines two nucleoside reverse transcriptase inhibitors, offering a dual‑mechanism that can simplify regimens compared with single‑agent NRTIs. Compared with protease inhibitors or integrase inhibitors, it may have a different side‑effect profile and drug‑interaction potential, making it suitable for certain patient populations.

Store Lamivudină/Zidovudină tablets at ambient temperature, below 25 °C, in the original container. Protect the product from moisture, excessive heat, and direct sunlight to maintain stability and potency throughout its shelf life.

Lamivudină/Zidovudină is taken orally, usually with or without food, as directed by the prescribing physician. The tablets should be swallowed whole with water and not crushed or chewed unless specifically instructed.

Serious adverse events include severe liver toxicity, lactic acidosis, profound neutropenia, hypersensitivity reactions, pancreatitis, and bone‑marrow suppression. Patients should be monitored regularly for signs of these conditions, and therapy should be discontinued if any serious reaction occurs.

Individuals with known hypersensitivity to lamivudine, zidovudine, or any excipients in the formulation should avoid this medication. Caution is also advised for patients with severe hepatic or hematologic disorders, and the drug should be used only under medical supervision in such cases.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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