Zoladex LA 10.8mg (Goserelin Acetate PFS) 10.8mg

Zoladex LA 10.8mg is a hormone therapy used to treat various conditions by reducing the production of sex hormones.

• Prostate cancer: Reduces testosterone production to slow the growth of cancer cells.
• Breast cancer: Decreases oestrogen levels to inhibit the growth of hormone-sensitive breast cancer.
• Endometriosis: Reduces the size and symptoms of endometrial tissue growth outside the uterus.
• Uterine fibroids: Helps shrink fibroids and alleviate associated symptoms.
• Precocious puberty: Delays the onset of puberty in children.

• Goserelin acetate is a synthetic analogue of gonadotropin-releasing hormone (GnRH). It initially stimulates the pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH), but prolonged administration leads to down-regulation and desensitization of GnRH receptors. This results in decreased secretion of LH and FSH, leading to suppression of sex hormone production and achieving medical castration.

Zoladex LA 10.8mg may cause various side effects, ranging from common to serious.

Common Side Effects

• Hot flushes and sweating.
• Erectile dysfunction and reduced interest in sex.
• Vaginal dryness or bleeding, acne, and changes in breast size (in women).
• Depressed mood and tingling in the fingers or toes.
• Skin rash, bone pain, and reactions at the site of injection.
• Decreased bone density and changes in blood pressure.
• Weight changes and an increased risk of heart attack (in men).

Serious or Rare Side Effects

• Increased risk of heart attack (in men).
• Decreased bone density leading to osteoporosis.
• Severe allergic reactions.
• Changes in blood pressure that may require monitoring.

Zoladex LA 10.8mg should be used with caution and under medical supervision.

• Inform your doctor about any allergies: Notify your healthcare provider if you have any known allergies to goserelin or any other medications.
• Pregnancy and breastfeeding: Avoid use during pregnancy and breastfeeding unless specifically advised by your doctor.
• Diabetes monitoring: Goserelin can affect blood sugar levels, so frequent monitoring is advised for diabetic patients.
• Bone density monitoring: Regular monitoring of bone density may be required due to the risk of osteoporosis.
• Contraception: Use barrier methods of contraception during treatment.
• Storage: Store below 25°C: Keep in the original package and do not break the seal.
• Handling: The Zoladex LA 10.8mg Implant will be injected under the skin on your stomach every 12 weeks by a healthcare professional.

Zoladex LA 10.8mg may interact with other medications, so it is important to inform your healthcare provider about all the drugs you are taking.

Major Interactions (Avoid)

• Avoid using oral contraceptives: Do not use oral contraceptives ('the pill') during treatment with goserelin.
• Avoid concurrent use with other GnRH agonists: Concurrent use may increase the risk of side effects.
• Avoid use with drugs that affect blood sugar levels: Monitor blood glucose levels closely if taking medications that affect blood sugar.

Moderate Interactions (Monitor Closely)

• Monitor for changes in blood pressure: Use with caution if taking medications that affect blood pressure.
• Monitor for changes in bone density: Use with caution if taking medications that affect bone density.
• Monitor for changes in mood: Use with caution if taking medications that affect mood or mental health.