Product image of Limován (Zopiclone) supplied by GNH India

Limován

Active Ingredient:
Zopiclone
Origin:
EU

Limován (Zopiclone)

Zopiclone, the active ingredient in Limován, is a cyclopyrrolone (non‑benzodiazepine hypnotic) presented as an oral tablet for oral use. It is indicated for short‑term treatment of insomnia in adults who have difficulty falling or staying asleep.

GNH India supplies Limován as a licensed, GDP‑compliant international pharmaceutical supplier serving hospitals, pharmacies and clinics worldwide.

Manufacturer / TM Owner

Sanofi-Aventis, S.A.

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Indications & Clinical Uses

  • Zopiclone is a hypnotic agent that acts on the central nervous system to treat sleep disorders.
  • Insomnia (short‑term): helps initiate and maintain sleep in adults.
  • Sleep onset insomnia: reduces the time needed to fall asleep.
  • Sleep maintenance insomnia: decreases nocturnal awakenings and improves sleep continuity.

How It Works

  • Zopiclone binds as a positive allosteric modulator to the benzodiazepine site of the GABA‑A receptor complex. This enhances the inhibitory effect of GABA, increasing chloride ion influx and hyperpolarising neuronal membranes, which leads to reduced neuronal excitability and promotes sedation and sleep onset.

Side Effects

Zopiclone may cause a range of adverse reactions, from mild to severe.

Common Side Effects

  • Bitter or metallic taste.
  • Dry mouth.
  • Drowsiness or fatigue during the day.
  • Headache.

Serious or Rare Side Effects

  • Complex sleep behaviours such as sleep‑walking or driving while not fully awake.
  • Allergic reactions including rash, itching, or swelling.
  • Severe respiratory depression, especially when combined with other depressants.

Precautions & Warnings

  • Before using Limován, consider the following safety measures.
  • Avoid abrupt discontinuation: taper under medical supervision to reduce withdrawal risk.
  • Limit alcohol: concurrent use may increase sedation and respiratory depression.
  • Use caution in the elderly: increased sensitivity may lead to falls or confusion.
  • Assess liver function: impaired metabolism can raise drug levels.
  • Store at ambient temperature: keep below 25°C in the original container, protected from moisture and light.

Avoid Interactions

Zopiclone can interact with several other medicines; awareness helps prevent adverse outcomes.

Major Interactions (Avoid)

  • Opioids: additive respiratory depression.
  • Central nervous system depressants (e.g., barbiturates, antihistamines): heightened sedation.
  • Strong CYP3A4 inhibitors (e.g., ketoconazole): increased plasma concentrations.

Moderate Interactions (Monitor Closely):\n- CYP3A4 inducers (e.g., rifampicin): reduced efficacy.

  • Antidepressants (e.g., fluoxetine): may enhance sedative effect.
  • Antihypertensives: potential additive hypotensive effect.

Frequently Asked Questions

Limován contains Zopiclone and is prescribed for the short‑term management of insomnia. It helps adults who have difficulty falling asleep, staying asleep, or experience frequent nighttime awakenings, improving overall sleep quality for a limited period as directed by a healthcare professional.

Zopiclone acts as a positive allosteric modulator at the benzodiazepine binding site of GABA‑A receptors. By enhancing GABA‑mediated chloride influx, it increases neuronal inhibition, producing a calming effect that facilitates the initiation and maintenance of sleep.

The exact dose of Limován is determined by the prescribing clinician based on the patient’s age, medical history, and response to therapy. Typical adult regimens start with the lowest effective dose, taken shortly before bedtime, and are adjusted only under medical supervision.

Safety data for Zopiclone in pregnancy and lactation are limited, and the drug is generally avoided unless the potential benefit outweighs the risk. Women who are pregnant, planning to become pregnant, or breastfeeding should discuss alternative treatments with their healthcare provider.

To place an order, submit an enquiry on the Limován product page at gnhindia.com, specifying the required quantity. GNH India works with hospitals, pharmacies, and procurement teams worldwide, verifies trade or institutional credentials, and then provides pricing, availability, shipping details, and any necessary import documentation.

Limován (Zopiclone) belongs to the cyclopyrrolone class, offering a rapid onset of sleep with a relatively short half‑life. Compared with benzodiazepines such as temazepam, Zopiclone may have a lower risk of dependence but shares similar sedative properties and requires careful monitoring for misuse.

Limován tablets should be stored at ambient temperature, below 25 °C, in the original blister pack to protect from moisture and light. Keep the medication out of reach of children and do not use it after the expiry date printed on the packaging.

Limován is taken orally with a glass of water, preferably just before bedtime. Patients should ensure they have a full night (7‑8 hours) of sleep opportunity and avoid activities requiring alertness, such as driving, after taking the medication.

Serious risks include complex sleep behaviours (e.g., sleep‑walking, sleep‑driving), severe allergic reactions, and respiratory depression, especially when combined with other central nervous system depressants or alcohol. Patients should seek immediate medical attention if they experience unusual sleep activities or difficulty breathing.

Limován is contraindicated in individuals with severe hepatic impairment, untreated sleep apnea, a history of substance misuse, or known hypersensitivity to Zopiclone. It should also be avoided in patients taking strong CYP3A4 inhibitors without medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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