ZOVIRAX 400mg (Aciclovir Tablet) 400 mg

Zovirax 400mg is an antiviral prescription medication containing the active ingredient aciclovir. It belongs to the drug class known as nucleoside analogue DNA polymerase inhibitors, which work by interfering with viral DNA replication. This oral tablet is commonly prescribed to manage and treat specific viral infections, such as those caused by the herpes simplex and varicella-zoster viruses.

Strength

400 mg

Pack Size

10s

Storage

Below 25°C

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Pack/s

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Indications & Clinical Uses

Zovirax 400mg tablets are indicated for the treatment of herpes simplex virus (HSV) infections of the skin and mucous membranes, including initial and recurrent genital herpes. It is also used for the treatment of varicella-zoster virus infections, commonly known as shingles (herpes zoster) or chickenpox. Additionally, it may be prescribed as a preventative measure (prophylaxis) to prevent herpes simplex infections in immunocompromised patients.

Side Effects

Common side effects associated with Zovirax 400mg may include headache, dizziness, nausea, vomiting, diarrhea, abdominal pain, skin rashes, and fatigue. Less common but serious side effects can include kidney impairment, neurological reactions (such as confusion or hallucinations, particularly in elderly patients or those with renal issues), and severe allergic reactions. Patients should consult a healthcare professional if they experience persistent or worsening symptoms.

Precautions & Warnings

Before taking Zovirax 400mg, patients should inform their healthcare provider of any pre-existing kidney disease, as dose adjustments may be necessary. Adequate hydration should be maintained during treatment to reduce the risk of renal toxicity. This medication is classified as Pregnancy Category B, meaning it should only be used during pregnancy if clearly needed and prescribed by a doctor. Elderly patients should be monitored closely due to an increased risk of neurological side effects.

Avoid Interactions

Zovirax 400mg may interact with other medications, particularly those that affect kidney function or are eliminated through the kidneys. Concurrent use with drugs like probenecid, cimetidine, or mycophenolate mofetil can increase the concentration of aciclovir in the blood. Patients should disclose all prescription drugs, over-the-counter medications, and herbal supplements they are taking to their physician before starting therapy.

Frequently Asked Questions

Zovirax 400mg is primarily used to treat infections caused by the herpes simplex virus (such as cold sores and genital herpes) and the varicella-zoster virus (which causes shingles and chickenpox). It is also used to prevent herpes infections in individuals with weakened immune systems.

Aciclovir, the active ingredient in Zovirax 400mg, is a nucleoside analogue DNA polymerase inhibitor. It works by selectively inhibiting viral DNA replication, preventing the virus from multiplying and spreading within the body, which helps the immune system clear the infection.

Zovirax 400mg is classified as Pregnancy Category B. While studies in animals have not shown harm to the fetus, adequate and well-controlled studies in pregnant women are limited. It should only be used during pregnancy if the potential benefits outweigh the risks, under the direct supervision of a healthcare provider.

If you miss a dose of Zovirax 400mg, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.

There are no specific food restrictions when taking Zovirax 400mg; it can be taken with or without food. However, it is highly recommended to drink plenty of water and stay well-hydrated during treatment to help protect your kidneys.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated: 17 Jun 2026

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