Andexxa US (Andexanet Alfa Injection) 200mg

Andexxa US (andexanet alfa) injection 200mg is a reversal agent for anticoagulants like apixaban or rivaroxaban. Designed for urgent bleeding control in adults. Store between 2–8°C. Prescription required.

Strength

200mg

Pack Size

Storage

2-8°

Manufacturer / TM Owner

Portola Pharmaceuticals

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Indications & Clinical Uses

Andexxa US is used to reverse the effects of certain blood thinners (anticoagulants) when rapid reversal is needed due to life-threatening or uncontrolled bleeding. It works by binding to the anticoagulant and neutralizing its activity. This medication is typically administered in a healthcare setting where bleeding can be closely monitored. It is not intended for routine reversal or for patients without active bleeding.

Side Effects

After administration, Andexxa US helps restore normal blood clotting function by counteracting the anticoagulant’s effects. Patients may experience improved clotting stability, though individual responses vary. The injection is formulated for intravenous use and is designed to act quickly to support bleeding management. Effects are monitored by healthcare professionals during and after administration.

Precautions & Warnings

Andexxa US should only be used under medical supervision due to the risk of serious blood clots forming after reversal. It is not suitable for patients with known allergies to andexanet alfa or its components. Healthcare providers will assess the patient’s bleeding status and clotting risk before administration. Keep the product refrigerated between 2–8°C and protect from light until use.

Avoid Interactions

No direct drug interactions have been established with andexanet alfa itself. However, since it reverses anticoagulants, the risk of blood clots may increase after use, especially in patients with a history of thrombosis. Caution is advised when used with other pro-coagulant therapies. Always inform your healthcare provider about all medications being taken.

Frequently Asked Questions

It is used to reverse the effects of blood thinners like apixaban or rivaroxaban in cases of life-threatening bleeding.

It is given as an intravenous injection in a clinical setting by healthcare professionals.

It is specifically designed to reverse factor Xa inhibitors such as apixaban and rivaroxaban.

Store between 2–8°C and protect from light until ready for use.

Yes, it is a prescription medication and should only be used under medical supervision.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated: 29 Jul 2026

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