Apo-Sitagliptin/Metformin XR 500 mg (Metformin Hydrochloride TABLET (EXTENDED-RELEASE)) 500 MG

APO-SITAGLIPTIN/METFORMIN XR 500 MG is an extended-release tablet combining sitagliptin and metformin hydrochloride. It is commonly used to manage type 2 diabetes by improving blood sugar control. This medication is manufactured by Apotex Inc. in Canada.

Strength

500 MG

Manufacturer / TM Owner

APOTEX INC

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Indications & Clinical Uses

APO-SITAGLIPTIN/METFORMIN XR 500 MG is primarily used to help control blood sugar levels in adults with type 2 diabetes. It works by increasing insulin sensitivity and reducing sugar production in the liver. This combination medication is often prescribed when diet and exercise alone are not enough to manage blood glucose levels effectively.

Side Effects

Common effects of APO-SITAGLIPTIN/METFORMIN XR 500 MG may include gastrointestinal discomfort, such as nausea, diarrhea, or stomach pain. Some users may also experience headache, dizziness, or a metallic taste in the mouth. These effects are usually mild and temporary, but persistent or severe symptoms should be discussed with a healthcare provider.

Precautions & Warnings

APO-SITAGLIPTIN/METFORMIN XR 500 MG should be taken exactly as directed, typically with the evening meal to minimize gastrointestinal side effects. It is important to stay hydrated and maintain a balanced diet while using this medication. Patients with kidney problems or a history of lactic acidosis should consult their healthcare provider before use.

Avoid Interactions

APO-SITAGLIPTIN/METFORMIN XR 500 MG may interact with certain medications, including those that affect kidney function or blood sugar levels. Alcohol consumption should be limited, as it can increase the risk of lactic acidosis. Always inform your healthcare provider about all medications and supplements you are taking to avoid potential interactions.

Frequently Asked Questions

APO-SITAGLIPTIN/METFORMIN XR 500 MG is used to help manage blood sugar levels in adults with type 2 diabetes.

APO-SITAGLIPTIN/METFORMIN XR 500 MG is typically taken once daily with the evening meal to minimize gastrointestinal side effects.

Common side effects may include nausea, diarrhea, stomach pain, headache, dizziness, and a metallic taste in the mouth.

APO-SITAGLIPTIN/METFORMIN XR 500 MG may interact with certain medications, so it is important to consult a healthcare provider before combining it with other drugs.

APO-SITAGLIPTIN/METFORMIN XR 500 MG may not be suitable for individuals with kidney problems or a history of lactic acidosis. Always consult a healthcare provider before use.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated: 29 Jul 2026

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