Product image of Arestin Microspheres 1 mg (Minocycline (Minocycline Hydrochloride)) 1 MG POWDER (EXTENDED RELEASE) supplied by GNH India

Arestin Microspheres 1 mg

Active Ingredient:
Minocycline (Minocycline Hydrochloride)
Form:
POWDER (EXTENDED RELEASE)
Brand:
ARESTIN MICROSPHERES
Origin:
UNITED STATES

Arestin Microspheres 1 mg (Minocycline (Minocycline Hydrochloride) POWDER (EXTENDED RELEASE)) 1 MG

Minocycline, the active ingredient in Arestin Microspheres 1 mg, is a tetracycline antibiotic presented as a 1 mg powder for extended-release microspheres for subgingival use. It is indicated as an adjunct to scaling and root planing (SRP) procedures for the reduction of pocket depth in patients with adult periodontitis.

GNH India supplies Arestin Microspheres 1 mg as a licensed, GDP-compliant international pharmaceutical supplier serving pharmacies and clinics worldwide.

Strength

1 MG

Pack Size

24X1MG

Manufacturer / TM Owner

ORA PHARMA INC.

1
Pack/s
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Indications & Clinical Uses

Arestin Microspheres 1 mg is a tetracycline antibiotic used in the management of periodontal disease. It is designed for localized application in dental care, delivering medication directly to the affected areas.

  • Adult periodontitis: Reduces pocket depth as an adjunct to scaling and root planing procedures.
  • Periodontal pockets: Targets and reduces bacteria in the gums to manage infections.
  • Chronic periodontal disease: Aids in the conservative treatment of chronic periodontal disease prior to surgery.

How It Works

  • Minocycline, the active ingredient in Arestin Microspheres 1 mg, inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. This prevents the attachment of aminoacyl-tRNA, thereby halting bacterial growth and replication. The extended-release formulation ensures sustained delivery of the antibiotic directly to the infection site, enhancing its efficacy in managing periodontal disease.

Side Effects

Arestin Microspheres 1 mg may cause various side effects, ranging from common to serious or rare.

Common Side Effects

  • Localized discomfort or sensitivity at the application site.
  • Mild irritation or swelling around the treated area.
  • Temporary discomfort during or after administration.
  • Headache.
  • Infection.
  • Flu symptoms.
  • Pain.

Serious or Rare Side Effects

  • Allergic reactions, such as rash, itching, or swelling.
  • Severe irritation or prolonged swelling at the application site.
  • Signs of infection that worsen or do not improve.

Precautions & Warnings

Arestin Microspheres 1 mg should be used with caution and under the guidance of a dental professional. Important precautions include:

  • Allergies: Inform your dental professional if you are allergic to minocycline or tetracyclines.
  • Pregnancy: Avoid use during pregnancy as it may cause permanent discoloration of the teeth in developing fetuses.
  • Breastfeeding: Avoid use while breastfeeding due to potential risks to the infant.
  • Children: Not recommended for use in children due to the risk of tooth discoloration.
  • Weakened immune systems: Has not been studied in patients with weakened immune systems, such as those with HIV infections or diabetes.
  • Store at room temperature: Keep in a cool, dry place and follow the storage instructions provided.

Avoid Interactions

Arestin Microspheres 1 mg may interact with other medications, requiring careful monitoring or avoidance.

Major Interactions (Avoid)

  • Tetracycline-class drugs: Avoid concurrent use with other tetracycline-class antibiotics to prevent increased side effects.
  • Antacids: Avoid taking antacids within 2 hours of administration to prevent reduced effectiveness.
  • Dairy products: Avoid consuming dairy products within 2 hours of administration to prevent reduced absorption.

Moderate Interactions (Monitor Closely)

  • Oral contraceptives: Monitor for reduced effectiveness of oral contraceptives when used concurrently.
  • Warfarin: Monitor for increased anticoagulant effects when used concurrently.
  • Methoxyflurane: Monitor for increased risk of nephrotoxicity when used concurrently.

Frequently Asked Questions

Arestin Microspheres 1 mg is used as an adjunct to scaling and root planing (SRP) procedures for the reduction of pocket depth in patients with adult periodontitis. It is a subgingival extended-release powder containing minocycline hydrochloride, which is applied directly into the periodontal pockets to manage bacterial infections in the gums.

Minocycline, the active ingredient in Arestin Microspheres 1 mg, inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit. This prevents the attachment of aminoacyl-tRNA, thereby halting bacterial growth and replication. The extended-release formulation ensures sustained delivery of the antibiotic directly to the infection site, enhancing its efficacy in managing periodontal disease.

The dose of Arestin Microspheres 1 mg is determined by a dental professional based on the individual needs of the patient. Each cartridge contains 1 mg of minocycline hydrochloride and is designed for a single application into a periodontal pocket. The prescriber will determine the appropriate dosage and administration schedule.

Arestin Microspheres 1 mg should be avoided during pregnancy and breastfeeding. The use of tetracycline-class drugs, including minocycline, during tooth development may cause permanent discoloration of the teeth. Therefore, it is not recommended for use in pregnant or breastfeeding women.

To order Arestin Microspheres 1 mg from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets. The team will ask you to confirm your trade or institutional credentials and will reply with pricing, availability, shipping, and the necessary import paperwork.

Arestin Microspheres 1 mg is a locally applied antibiotic that delivers a concentrated dose directly to the base of the periodontal pocket. Unlike systemic antibiotics, it targets the infection site specifically, reducing the risk of systemic side effects. It is also bioresorbable, meaning it does not require removal after administration, making it a convenient option for periodontal treatment.

Arestin Microspheres 1 mg should be stored at room temperature in a cool, dry place. It is important to follow the storage instructions provided to maintain the effectiveness of the medication. The medication should be handled with care to avoid contamination and should be kept out of reach of children.

Arestin Microspheres 1 mg is administered by a dental professional using a specially designed cartridge handle. The cartridge is inserted into the handle, and the powder is expressed into the periodontal pocket. The administration process is quick and does not require local anesthesia. Patients should avoid brushing the treated area for 12 hours and abstain from using interproximal cleaning devices for 10 days.

The most serious risks associated with Arestin Microspheres 1 mg include allergic reactions, such as rash, itching, or swelling, and severe irritation or prolonged swelling at the application site. Patients should inform their dental professional if they experience any signs of an allergic reaction or if their symptoms worsen or do not improve.

Arestin Microspheres 1 mg should not be used by individuals who are allergic to minocycline or tetracyclines. It is also not recommended for use in children, pregnant women, or breastfeeding women due to the risk of tooth discoloration. Patients with weakened immune systems, such as those with HIV infections or diabetes, should consult their dental professional before using this medication.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

References

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