Product image of Baclofen 10 mg/1 (Baclofen) 10 mg/1 TABLET supplied by GNH India

Baclofen 10 mg/1

Active Ingredient:
Baclofen
Form:
TABLET
Brand:
Baclofen
Origin:
USA

Baclofen 10 mg/1 (Baclofen TABLET) 10 mg/1

Baclofen, the active ingredient in Baclofen 10 mg, is a muscle relaxant presented as a 10 mg tablet for oral use. It is used to alleviate signs and symptoms of spasticity resulting from multiple sclerosis, spinal cord injuries, and other spinal cord diseases.

GNH India supplies Baclofen 10 mg as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide.

Strength

10 mg/1

Pack Size

500 TABLET in 1 BOTTLE (0115-1010-02)

Manufacturer / TM Owner

Amneal Pharmaceuticals of New York LLC

1
Pack/s
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Indications & Clinical Uses

Baclofen 10 mg is a muscle relaxant used to manage spasticity and muscle spasms.

  • Multiple sclerosis: Reduces flexor spasms, pain, clonus, and muscular rigidity.
  • Spinal cord injuries: Alleviates spasticity and improves muscle function.
  • Spinal cord diseases: May help manage spasticity and related symptoms.
  • Muscle spasm: Not indicated for skeletal muscle spasm resulting from rheumatic disorders.
  • Stroke, cerebral palsy, and Parkinson's disease: Efficacy not established, not recommended for these conditions.

How It Works

  • Baclofen works by acting as a GABA_B receptor agonist, which reduces excitatory neurotransmission in the spinal cord. This action decreases muscle tone and helps alleviate spasticity. The precise mechanism of action is not fully understood, but it is believed to involve hyperpolarization of afferent terminals and actions at supraspinal sites.

Side Effects

Baclofen 10 mg may cause various side effects, ranging from common to serious.

Common Side Effects

  • Drowsiness: Transient drowsiness is the most common side effect.
  • Dizziness: May occur in some patients.
  • Weakness: Can affect muscle strength.
  • Fatigue: May cause tiredness.
  • Nausea: Gastrointestinal discomfort.
  • Constipation: May affect bowel movements.
  • Urinary frequency: Increased need to urinate.
  • Headache: May occur in some individuals.

Serious or Rare Side Effects

  • Confusion: May affect cognitive function.
  • Hallucinations: Rare but possible.
  • Seizures: Rare instances reported.
  • Hypotension: Low blood pressure.
  • Dyspnea: Difficulty breathing.
  • Syncope: Fainting.
  • Chest pain: Rare but serious.

Precautions & Warnings

Baclofen 10 mg should be used with caution and under medical supervision.

  • Hypersensitivity: Avoid if allergic to baclofen.
  • Abrupt withdrawal: Gradually reduce dosage to avoid withdrawal symptoms.
  • Pregnancy: Use only if the benefit justifies the risk to the fetus.
  • Breastfeeding: Consult a healthcare provider before use.
  • Renal impairment: Dosage adjustment may be necessary.
  • Elderly: Monitor closely for side effects.
  • Store at 20° to 25°C: Keep in a well-closed container, protect from moisture.

Avoid Interactions

Baclofen 10 mg may interact with other medications, potentially affecting its efficacy or increasing the risk of side effects.

Major Interactions (Avoid)

  • Alcohol: May enhance sedative effects.
  • CNS depressants: Increased risk of drowsiness and respiratory depression.
  • Antihypertensives: May cause additive hypotensive effects.

Moderate Interactions (Monitor Closely)

  • Antiepileptics: May affect seizure control.
  • Antipsychotics: Increased risk of side effects.
  • Opioids: Enhanced sedative effects.
  • Antidepressants: May increase the risk of side effects.

Frequently Asked Questions

Baclofen 10 mg is used to alleviate signs and symptoms of spasticity resulting from multiple sclerosis, spinal cord injuries, and other spinal cord diseases. It helps reduce flexor spasms, pain, clonus, and muscular rigidity, improving muscle function and quality of life for patients with these conditions.

Baclofen works by acting as a GABA_B receptor agonist, which reduces excitatory neurotransmission in the spinal cord. This action decreases muscle tone and helps alleviate spasticity. The precise mechanism of action is not fully understood, but it is believed to involve hyperpolarization of afferent terminals and actions at supraspinal sites.

The dosage of Baclofen 10 mg is determined by the prescribing healthcare provider based on individual patient needs. Therapy typically starts at a low dosage and is gradually increased until the optimum effect is achieved, usually between 40 to 80 mg daily. The lowest dose compatible with an optimal response is recommended.

Baclofen should be used during pregnancy only if the benefit clearly justifies the potential risk to the fetus. Animal studies have shown some adverse effects on fetal development, but there are no adequate and well-controlled studies in pregnant women. Consult a healthcare provider before use.

To order Baclofen 10 mg from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets. The team will ask you to confirm your trade or institutional credentials and will reply with pricing, availability, shipping, and the necessary import paperwork.

Baclofen is a muscle relaxant that specifically targets spasticity resulting from conditions like multiple sclerosis and spinal cord injuries. Compared to other muscle relaxants, Baclofen has a unique mechanism of action as a GABA_B receptor agonist, which makes it particularly effective for spasticity. Other muscle relaxants may be used for different types of muscle spasms or conditions.

Baclofen 10 mg should be stored at 20° to 25°C (68° to 77°F) in a well-closed container, protecting it from moisture. Keep the medication in its original packaging and ensure it is stored out of reach of children and pets. Follow the storage instructions provided on the label to maintain the efficacy and safety of the medication.

Baclofen 10 mg is administered orally, typically in the form of tablets. The tablets should be taken as directed by the healthcare provider, usually with a glass of water. It is important to follow the prescribed dosage and not to exceed the recommended dose without medical advice. The tablets should be swallowed whole and not crushed or chewed.

The most serious risks associated with Baclofen include seizures, hallucinations, confusion, hypotension, dyspnea, and syncope. These side effects are rare but can be serious. Patients should be monitored closely for any signs of these adverse effects, and medical attention should be sought immediately if they occur. Always use Baclofen under medical supervision.

Baclofen 10 mg should not be used by individuals who are hypersensitive to baclofen. It should be used with caution in patients with renal impairment, as dosage adjustment may be necessary. Pregnant women should use Baclofen only if the benefit justifies the risk to the fetus. Always consult a healthcare provider before starting Baclofen to ensure it is safe for you.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

References

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