Product image of Buprenorphine 2 mg/1 (Buprenorphine) 2 mg/1 TABLET supplied by GNH India

Buprenorphine 2 mg/1

Active Ingredient:
Buprenorphine
Form:
TABLET
Brand:
Buprenorphine
Origin:
USA

Buprenorphine 2 mg/1 (Buprenorphine TABLET) 2 mg/1

Buprenorphine, the active ingredient in Buprenorphine, is a partial opioid agonist presented as a 2 mg/tablet for sublingual use. It is used to treat moderate to severe chronic pain and opioid dependence. GNH India supplies Buprenorphine as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals and clinics worldwide.

Buprenorphine is a well-established medication for managing opioid use disorder and chronic pain. Its unique pharmacological profile makes it a valuable tool in addiction treatment and pain management.

Strength

2 mg/1

Pack Size

30 TABLET in 1 BOTTLE (0054-0176-13)

Manufacturer / TM Owner

Hikma Pharmaceuticals USA Inc.

1
Pack/s
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Indications & Clinical Uses

Buprenorphine is used to manage opioid use disorder and moderate to severe chronic pain. It helps by:

  • Opioid dependence treatment: Reduces withdrawal symptoms and cravings for opioids.
  • Chronic pain management: Provides analgesia for moderate to severe pain.
  • Opioid overdose prevention: Lowers the risk of overdose due to its ceiling effect on respiratory depression.
  • Maintenance therapy: Supports long-term recovery from opioid addiction.
  • Harm reduction: Helps individuals stabilize and reduce the harmful effects of opioid use.

How It Works

  • Buprenorphine acts as a partial agonist at the mu-opioid receptor and an antagonist at the kappa-opioid receptor. This dual action provides analgesia while limiting the risk of respiratory depression, a common side effect of full opioid agonists. Its ceiling effect means that increasing doses beyond a certain point do not significantly increase its effects, enhancing its safety profile.

Side Effects

Buprenorphine can cause various side effects, ranging from common to serious. Common Side Effects:

  • Nausea and vomiting
  • Constipation
  • Headache
  • Sweating
  • Dizziness
  • Insomnia
  • Fatigue

Serious or Rare Side Effects

  • Respiratory depression
  • Allergic reactions
  • Liver toxicity
  • Hormonal imbalances
  • Dependence and abuse potential
  • Withdrawal symptoms upon discontinuation

Precautions & Warnings

Buprenorphine should be used with caution and under medical supervision. Important precautions include:

  • Pregnancy: Use with caution, as it may affect the newborn.
  • Breastfeeding: Consult a healthcare provider before use.
  • Driving: Avoid operating heavy machinery until the effects are known.
  • Alcohol: Avoid alcohol consumption to prevent increased sedation.
  • Other medications: Inform your doctor about all medications you are taking.
  • Storage: Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F).

Avoid Interactions

Buprenorphine can interact with other medications, potentially altering its effects or increasing the risk of side effects. Major Interactions (Avoid):

  • Other opioids: Can increase the risk of respiratory depression.
  • Benzodiazepines: Can cause severe sedation and respiratory depression.
  • Alcohol: Can enhance the sedative effects of buprenorphine.
  • MAO inhibitors: Can increase the risk of serotonin syndrome.

Moderate Interactions (Monitor Closely)

  • Antidepressants: May increase the risk of side effects.
  • Antipsychotics: Can enhance the sedative effects of buprenorphine.
  • Antihistamines: May increase drowsiness.

Frequently Asked Questions

Buprenorphine is used to treat opioid use disorder and moderate to severe chronic pain. It helps reduce withdrawal symptoms and cravings for opioids, making it a valuable tool in addiction treatment and pain management.

Buprenorphine acts as a partial agonist at the mu-opioid receptor and an antagonist at the kappa-opioid receptor. This dual action provides analgesia while limiting the risk of respiratory depression, a common side effect of full opioid agonists.

The usual starting dosage of Buprenorphine ranges from 2 to 8 mg once per day. The dosage is adjusted by the prescriber based on the individual's response and needs, with a recommended target dosage of 16 mg once per day for long-term treatment.

Buprenorphine should be used with caution during pregnancy and breastfeeding. It may affect the newborn, and its use should be carefully monitored by a healthcare provider.

To order Buprenorphine from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets and will ask the buyer to confirm trade or institutional credentials. The team will reply with pricing, availability, shipping, and the import paperwork.

Buprenorphine has a lower risk of respiratory depression compared to full opioid agonists like morphine and oxycodone. Its ceiling effect makes it safer for long-term use and reduces the risk of overdose.

Buprenorphine should be stored at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Keep it out of reach of children and pets, and dispose of any unused medication properly.

Buprenorphine is typically administered as a sublingual tablet, which is placed under the tongue and allowed to dissolve. It is usually taken once per day as directed by a healthcare provider.

The most serious risks associated with Buprenorphine include respiratory depression, allergic reactions, liver toxicity, and the potential for dependence and abuse. It is important to use Buprenorphine under medical supervision.

Buprenorphine should not be used by individuals with severe respiratory depression, acute asthma, or a known hypersensitivity to buprenorphine. It should be used with caution in individuals with liver disease, head injuries, or a history of substance abuse.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

References

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