Product image of Cevimeline Hydrochloride 30 mg/1 (Cevimeline Hydrochloride) 30 mg/1 CAPSULE supplied by GNH India

Cevimeline Hydrochloride 30 mg/1

Active Ingredient:
Cevimeline Hydrochloride
Form:
CAPSULE
Brand:
cevimeline hydrochloride
Origin:
USA

Cevimeline Hydrochloride 30 mg/1 (Cevimeline Hydrochloride CAPSULE) 30 mg/1

Cevimeline hydrochloride, the active ingredient in cevimeline hydrochloride, is a muscarinic cholinergic agonist presented as a 30 mg capsule for oral use. It is used to treat symptoms of dry mouth in patients with Sjögren’s syndrome, a condition that affects the immune system and causes dryness in certain parts of the body such as the eyes and mouth.

GNH India supplies cevimeline hydrochloride as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide.

Strength

30 mg/1

Pack Size

100 CAPSULE in 1 BOTTLE, PLASTIC (0713-0937-01)

Manufacturer / TM Owner

Cosette Pharmaceuticals, Inc.

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Indications & Clinical Uses

Cevimeline hydrochloride is a muscarinic cholinergic agonist used to treat symptoms of dry mouth in patients with Sjögren’s syndrome. It works by stimulating certain nerves to increase the amount of saliva produced, making it easier and more comfortable to speak and swallow.

  • Sjögren’s syndrome: Treats dry mouth (xerostomia) by stimulating salivary gland secretion.
  • Radiation-induced xerostomia: May be used to alleviate dry mouth caused by radiation therapy.

How It Works

  • Cevimeline hydrochloride works as a selective muscarinic (M1, M3) receptor agonist. It binds to these receptors on salivary glands, stimulating them to produce more saliva. This action helps to alleviate dry mouth symptoms in patients with Sjögren’s syndrome or those who have experienced radiation-induced xerostomia.

Side Effects

Cevimeline hydrochloride may cause side effects, which can vary in severity. Common side effects include mild to moderate symptoms, while serious or rare side effects are less frequent but more severe.

Common Side Effects

  • Sweating
  • Nausea
  • Runny nose (rhinitis)
  • Flushing
  • Frequent urge to urinate
  • Dizziness
  • Weakness
  • Diarrhea
  • Blurred vision

Serious or Rare Side Effects

  • Extreme fatigue
  • Irregular heartbeat
  • Swelling
  • Severe diarrhea
  • Severe blurred vision
  • Severe nausea or vomiting

Precautions & Warnings

Cevimeline hydrochloride should be used with caution in certain populations and conditions. It is important to follow the prescribed dosage and consult with a healthcare provider for personalized advice.

  • Heart conditions: Use with caution in patients with heart disease, as it may affect heart rate or rhythm.
  • Asthma: Avoid use in patients with uncontrolled asthma, as it can increase airway secretions and resistance.
  • Glaucoma: Use with caution in patients with narrow-angle (angle-closure) glaucoma, as it can narrow the pupil.
  • Pregnancy: Safety in pregnancy is unknown; consult a healthcare provider before use.
  • Breastfeeding: Safety during breastfeeding is unknown; consult a healthcare provider before use.
  • Storage: Store at room temperature away from light and moisture. Keep out of reach of children.

Avoid Interactions

Cevimeline hydrochloride may interact with other medications, which can affect its efficacy or increase the risk of side effects. It is important to inform your healthcare provider about all medications you are taking.

Major Interactions (Avoid)

  • Beta-blockers: May interact with cevimeline hydrochloride, affecting heart rate or blood pressure.
  • Anticholinergic drugs: May reduce the effectiveness of cevimeline hydrochloride.

Moderate Interactions (Monitor Closely)

  • Drugs that affect heart rate: May require monitoring when used with cevimeline hydrochloride.
  • Drugs that affect blood pressure: May require monitoring when used with cevimeline hydrochloride.
  • Drugs that affect gastrointestinal motility: May require monitoring when used with cevimeline hydrochloride.

Frequently Asked Questions

Cevimeline hydrochloride is used to treat symptoms of dry mouth in patients with Sjögren’s syndrome. It works by stimulating the salivary glands to produce more saliva, making it easier to speak and swallow. It may also be used to alleviate dry mouth caused by radiation therapy.

Cevimeline hydrochloride works as a selective muscarinic (M1, M3) receptor agonist. It binds to these receptors on salivary glands, stimulating them to produce more saliva. This action helps to alleviate dry mouth symptoms in patients with Sjögren’s syndrome or those who have experienced radiation-induced xerostomia.

The recommended dose of cevimeline hydrochloride is 30 mg taken three times a day. However, the prescriber sets the exact dosage based on the patient's medical condition and response to treatment. It is important to follow the prescribed dosage and consult with a healthcare provider for personalized advice.

The safety of cevimeline hydrochloride during pregnancy and breastfeeding is unknown. It is important to consult with a healthcare provider before using this medication if you are pregnant or breastfeeding. They can provide personalized advice based on your specific situation.

To order cevimeline hydrochloride from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets and will ask the buyer to confirm trade or institutional credentials. The team will then reply with pricing, availability, shipping, and the import paperwork.

Cevimeline hydrochloride is a muscarinic cholinergic agonist specifically indicated for treating dry mouth in patients with Sjögren’s syndrome. It works by stimulating the salivary glands to produce more saliva. Compared to other treatments, such as artificial saliva substitutes or pilocarpine, cevimeline hydrochloride may offer a different profile of efficacy and side effects. It is important to consult with a healthcare provider to determine the most appropriate treatment for your specific condition.

Cevimeline hydrochloride should be stored at room temperature away from light and moisture. It is important to keep the medication in its original packaging and out of reach of children. Follow the storage instructions provided on the packaging or by your healthcare provider to ensure the medication remains effective.

Cevimeline hydrochloride is administered orally in capsule form. It is usually taken three times a day, with or without food, as directed by your healthcare provider. It is important to follow the prescribed dosage and administration instructions to achieve the best results and minimize the risk of side effects.

While taking cevimeline hydrochloride, it is important to watch for serious or rare side effects such as extreme fatigue, irregular heartbeat, severe diarrhea, severe blurred vision, and severe nausea or vomiting. If you experience any of these symptoms, seek medical attention immediately. Always consult with your healthcare provider for personalized advice and monitoring.

Cevimeline hydrochloride should not be used by individuals with uncontrolled asthma, a known allergy to cevimeline, acute iritis, or narrow-angle (angle-closure) glaucoma. It should also be used with caution in patients with heart disease. Always consult with a healthcare provider to determine if cevimeline hydrochloride is appropriate for your specific condition.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

References

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