Product image of Creon 60000 [USP'U]/1 (Pancrelipase) 60000 [USP'U]/1 CAPSULE, DELAYED RELEASE PELLETS supplied by GNH India

Creon 60000 [USP'U]/1

Active Ingredient:
Pancrelipase
Form:
CAPSULE, DELAYED RELEASE PELLETS
Brand:
Creon
Origin:
USA

Creon 60000 [USP'U]/1 (Pancrelipase CAPSULE, DELAYED RELEASE PELLETS) 60000 [USP'U]/1

Pancrelipase, the active ingredient in Creon 60000 [USP'U]/1, is a pancreatic enzyme replacement therapy presented as a 60000 USP units per capsule, delayed-release pellets for oral use. It is used to aid digestion in patients with exocrine pancreatic insufficiency due to conditions such as cystic fibrosis, chronic pancreatitis, pancreatic cancer, or pancreatic resection.

GNH India supplies Creon 60000 [USP'U]/1 as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide.

Strength

60000 [USP'U]/1

Pack Size

100 CAPSULE, DELAYED RELEASE PELLETS in 1 BOTTLE (0032-1212-01)

Manufacturer / TM Owner

AbbVie Inc.

1
Pack/s
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Indications & Clinical Uses

Creon 60000 [USP'U]/1 is indicated for the treatment of exocrine pancreatic insufficiency, a condition where the pancreas does not produce enough digestive enzymes. This can occur due to various conditions, including:

  • Cystic fibrosis: Helps improve digestion and nutrient absorption in patients with cystic fibrosis.
  • Chronic pancreatitis: Aids in the digestion of fats, proteins, and carbohydrates in patients with chronic pancreatitis.
  • Pancreatic cancer: Supports digestion in patients who have undergone pancreatic resection or have pancreatic cancer.
  • Pancreatectomy: Assists in the digestion process for patients who have had part or all of their pancreas removed.

How It Works

  • Creon 60000 [USP'U]/1 works by providing exogenous lipase, amylase, and protease enzymes. These enzymes help break down fats, carbohydrates, and proteins in the digestive tract, compensating for the lack of natural pancreatic enzymes in patients with exocrine pancreatic insufficiency. The delayed-release formulation ensures that the enzymes are released in the small intestine, where they are most effective.

Side Effects

Creon 60000 [USP'U]/1 may cause side effects, although not everyone gets them. Common Side Effects:

  • Abdominal pain
  • Diarrhea
  • Nausea
  • Vomiting
  • Dizziness
  • Cough

Serious or Rare Side Effects

  • Fibrosing colonopathy: A serious condition that affects the colon.
  • Gastrointestinal obstruction: Blockage in the digestive tract.
  • Hyperuricemia: High levels of uric acid in the blood.
  • Pruritus ani: Itching around the anal area.
  • Urticaria: Hives or skin rash.

Precautions & Warnings

Creon 60000 [USP'U]/1 should be used with caution and under medical supervision. Important precautions include:

  • Do not crush, chew, or retain in the mouth: Ensure the capsule is swallowed whole to avoid irritation of the oral mucosa.
  • Do not exceed recommended dosage: Exceeding 2,500 lipase units/kg/meal or 10,000 lipase units/kg/day may increase the risk of side effects.
  • Monitor for fibrosing colonopathy: Regular monitoring is essential to detect any signs of this serious condition.
  • Avoid inhalation of powder: Care should be taken to avoid inhaling the powder when opening the capsule.
  • Store below 25°C: Keep in the original pack, protect from moisture.

Avoid Interactions

Creon 60000 [USP'U]/1 may interact with other medications. Major Interactions (Avoid):

  • Antacids: May decrease the effectiveness of Creon by altering stomach pH.
  • H2-receptor antagonists: Can reduce the activity of pancreatic enzymes.

Moderate Interactions (Monitor Closely)

  • Iron supplements: May reduce the absorption of iron.
  • Folic acid supplements: May interfere with the absorption of folic acid.
  • Other digestive enzymes: Concurrent use may lead to excessive enzyme activity.

Frequently Asked Questions

Creon 60000 [USP'U]/1 is used to treat exocrine pancreatic insufficiency, a condition where the pancreas does not produce enough digestive enzymes. This can occur due to conditions such as cystic fibrosis, chronic pancreatitis, pancreatic cancer, or pancreatic resection. The medication helps improve digestion and nutrient absorption in these patients.

Pancrelipase, the active ingredient in Creon 60000 [USP'U]/1, works by providing exogenous lipase, amylase, and protease enzymes. These enzymes help break down fats, carbohydrates, and proteins in the digestive tract, compensating for the lack of natural pancreatic enzymes in patients with exocrine pancreatic insufficiency. The delayed-release formulation ensures that the enzymes are released in the small intestine, where they are most effective.

The dosage of Creon 60000 [USP'U]/1 is determined by a healthcare provider based on the patient's condition, dietary fat intake, and individual response to the medication. It is typically taken with meals and snacks. The prescriber will adjust the dosage as needed to achieve optimal digestive function.

The safety of Creon 60000 [USP'U]/1 during pregnancy or breastfeeding has not been fully established. Pregnant or breastfeeding women should consult their healthcare provider before using this medication. The healthcare provider will weigh the potential benefits against the risks to determine if the medication is appropriate.

To order Creon 60000 [USP'U]/1 from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets. The team will ask you to confirm your trade or institutional credentials and will reply with pricing, availability, shipping, and the import paperwork.

Creon 60000 [USP'U]/1 is one of the leading pancreatic enzyme replacement therapies available. It is known for its delayed-release formulation, which ensures that the enzymes are released in the small intestine, where they are most effective. Compared to other therapies, Creon is widely prescribed and has a well-established safety and efficacy profile.

Creon 60000 [USP'U]/1 should be stored below 25°C, in the original pack, and protected from moisture. The capsules should be swallowed whole with a glass of water or juice to ensure that the pellets are swallowed. Do not crush, chew, or retain the capsules in the mouth to avoid irritation of the oral mucosa.

Creon 60000 [USP'U]/1 is administered orally with meals or snacks. The capsules should be swallowed whole with a glass of water or juice. For patients who have difficulty swallowing, the capsule can be opened, and the contents can be mixed with a small amount of soft food or liquid. Care should be taken to avoid inhaling the powder.

The most serious risks associated with Creon 60000 [USP'U]/1 include fibrosing colonopathy, gastrointestinal obstruction, and hyperuricemia. Patients should be monitored regularly for signs of these conditions. Any unusual symptoms should be reported to a healthcare provider immediately.

Creon 60000 [USP'U]/1 should not be used by individuals who are allergic to pork proteins or any of the other ingredients in the medication. Patients with certain medical conditions or those taking specific medications should consult their healthcare provider before using Creon to ensure it is safe for them.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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