Product image of Diazepam 10 mg/1 (Diazepam) 10 mg/1 TABLET supplied by GNH India

Diazepam 10 mg/1

Active Ingredient:
Diazepam
Form:
TABLET
Brand:
Diazepam
Origin:
USA

Diazepam 10 mg/1 (Diazepam TABLET) 10 mg/1

Diazepam, the active ingredient in Diazepam, is a benzodiazepine presented as a 10 mg tablet for oral use. It is used to treat anxiety disorders, muscle spasms, seizure disorders, alcohol withdrawal, and for sedation before procedures. GNH India supplies Diazepam as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide.

Diazepam is a widely recognized medication known for its anxiolytic, sedative, muscle relaxant, and anticonvulsant properties. It is classified as a Schedule IV controlled substance due to its potential for dependence and abuse.

Strength

10 mg/1

Pack Size

100 TABLET in 1 BOTTLE, PLASTIC (0378-0477-01)

Manufacturer / TM Owner

Mylan Pharmaceuticals Inc.

1
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Indications & Clinical Uses

Diazepam acts on the central nervous system to produce calming effects. It is used for various conditions, including:

  • Anxiety disorders: Reduces symptoms of anxiety and tension.
  • Muscle spasms: Relaxes skeletal muscles in conditions like cerebral palsy and multiple sclerosis.
  • Seizure disorders: Helps manage certain types of seizures, including status epilepticus.
  • Alcohol withdrawal: Alleviates symptoms of alcohol withdrawal, such as agitation and tremors.
  • Sedation before procedures: Provides preoperative sedation and anxiolysis for medical procedures.

How It Works

  • Diazepam enhances the activity of the neurotransmitter GABA at the GABA-A receptor, producing sedative, anxiolytic, muscle relaxant, and anticonvulsant effects. By binding to the benzodiazepine site on the GABA-A receptor, it increases the frequency of chloride ion channel opening, which hyperpolarizes the neuron and reduces its likelihood of firing. This mechanism leads to broad, dose-dependent central nervous system depression.

Side Effects

Diazepam can cause various side effects, ranging from common to serious or rare. Common Side Effects:

  • Drowsiness: A frequent side effect due to its sedative properties.
  • Dizziness: May occur as a result of the drug's central nervous system depression.
  • Muscle weakness: Can result from its muscle relaxant effects.
  • Fatigue: Often experienced due to the drug's sedative nature.
  • Dry mouth: A common side effect of many medications, including diazepam.

Serious or Rare Side Effects

  • Respiratory depression: Particularly when combined with other sedatives or alcohol.
  • Physical dependence: Prolonged use can lead to dependence and withdrawal symptoms.
  • Cognitive impairment: May affect memory and cognitive function, especially in the elderly.
  • Paradoxical reactions: Rarely, it can cause increased anxiety or agitation.

Precautions & Warnings

Diazepam should be used with caution and under medical supervision. Important precautions include:

  • Avoid abrupt discontinuation: Gradual tapering is necessary to prevent withdrawal symptoms.
  • Use in the elderly: Lower doses are recommended due to increased sensitivity.
  • Avoid alcohol: Concurrent use can enhance sedative effects and increase the risk of respiratory depression.
  • Pregnancy: Should be avoided unless clearly needed, as it can cause harm to the fetus.
  • Breastfeeding: Not recommended, as it can pass into breast milk and affect the infant.
  • Store below 30°C: Keep in the original pack, protect from moisture.

Avoid Interactions

Diazepam can interact with other medications, leading to potentially dangerous effects. Major Interactions (Avoid):

  • Opioids: Can cause severe respiratory depression and sedation.
  • Other benzodiazepines: May enhance sedative effects and increase the risk of overdose.
  • Alcohol: Can potentiate the sedative effects and increase the risk of respiratory depression.

Moderate Interactions (Monitor Closely)

  • Antidepressants: May enhance the sedative effects of diazepam.
  • Antihistamines: Can increase the risk of drowsiness and dizziness.
  • Antipsychotics: May enhance the sedative effects and increase the risk of cognitive impairment.

Frequently Asked Questions

Diazepam is used to treat anxiety disorders, muscle spasms, seizure disorders, alcohol withdrawal, and for sedation before medical procedures. It works by enhancing the effects of a neurotransmitter called GABA, which helps to calm the central nervous system.

Diazepam works by binding to the benzodiazepine site on the GABA-A receptor in the brain. This enhances the activity of the neurotransmitter GABA, leading to sedative, anxiolytic, muscle relaxant, and anticonvulsant effects. By increasing the frequency of chloride ion channel opening, it reduces the likelihood of neuronal firing, resulting in broad central nervous system depression.

The usual dose of Diazepam varies depending on the condition being treated and the patient's response. For anxiety, the typical dose ranges from 2 to 10 mg, taken 2 to 4 times daily. For muscle spasms, the dose is usually 2 to 10 mg, taken 3 to 4 times daily. The prescriber will determine the appropriate dose based on individual needs and medical history.

Diazepam is not recommended during pregnancy unless clearly needed, as it can cause harm to the fetus. It is also not recommended for use while breastfeeding, as it can pass into breast milk and affect the infant. Always consult a healthcare provider before using Diazepam during pregnancy or breastfeeding.

To order Diazepam from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets. The team will ask you to confirm your trade or institutional credentials and will reply with pricing, availability, shipping, and the necessary import paperwork.

Diazepam is known for its long half-life, which means it remains active in the body for a longer period compared to shorter-acting benzodiazepines like alprazolam. This makes it useful for conditions requiring prolonged effects, such as alcohol withdrawal. However, it also increases the risk of accumulation and prolonged withdrawal symptoms.

Diazepam should be stored below 30°C, in the original pack, and protected from moisture. It is important to keep it out of reach of children and pets. Always follow the storage instructions provided on the packaging to ensure the medication remains effective and safe.

Diazepam is typically administered orally in the form of tablets. It can also be given intravenously or intramuscularly in medical settings for conditions like status epilepticus or preoperative sedation. The route of administration depends on the specific medical need and the prescriber's instructions.

The most serious risks associated with Diazepam include respiratory depression, especially when combined with other sedatives or alcohol, physical dependence, and potentially life-threatening withdrawal symptoms if the medication is stopped abruptly. It is important to use Diazepam under medical supervision and follow the prescribed dosage.

Diazepam is contraindicated in individuals with hypersensitivity to benzodiazepines, severe respiratory insufficiency, myasthenia gravis, sleep apnea, severe hepatic insufficiency, and acute narrow-angle glaucoma. It should be used with caution in the elderly and those with a history of substance abuse. Always consult a healthcare provider before starting Diazepam.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

References

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