Product image of Dupixent 200 mg/1.14mL (Dupilumab) 200 mg/1.14mL INJECTION, SOLUTION supplied by GNH India

Dupixent 200 mg/1.14mL

Active Ingredient:
Dupilumab
Form:
INJECTION, SOLUTION
Brand:
Dupixent
Origin:
USA

Dupixent 200 mg/1.14mL (Dupilumab INJECTION, SOLUTION) 200 mg/1.14mL

Dupilumab, the active ingredient in Dupixent, is an interleukin-4 receptor alpha antagonist presented as a 200 mg/1.14 mL solution for subcutaneous use. It is used to treat moderate-to-severe atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyps in adults and children.

GNH India supplies Dupixent 200 mg/1.14mL as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide.

Strength

200 mg/1.14mL

Pack Size

2 SYRINGE, GLASS in 1 CARTON (0024-5919-20) / 1.14 mL in 1 SYRINGE, GLASS (0024-5919-01)

Manufacturer / TM Owner

sanofi-aventis U.S. LLC

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Indications & Clinical Uses

Dupixent 200 mg/1.14mL is primarily used to manage inflammatory conditions by targeting specific pathways involved in inflammation. It is prescribed for the following conditions:

  • Moderate-to-severe atopic dermatitis (eczema): Reduces symptoms and improves quality of life in adults and children.
  • Asthma: Used as an add-on treatment for severe asthma not adequately controlled by other medications.
  • Chronic rhinosinusitis with nasal polyps: Helps manage symptoms when other treatments have not been effective.

How It Works

  • Dupilumab works by binding to the IL-4Rα subunit, which blocks the signaling of interleukins 4 and 13. This action reduces type 2 inflammatory responses, thereby alleviating symptoms associated with conditions like atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyps.

Side Effects

Dupixent 200 mg/1.14mL may cause several side effects, ranging from common to serious. Common Side Effects:

  • Injection site reactions
  • Eye and eyelid inflammation
  • Cold symptoms
  • Joint pain
  • Temporary increase in eosinophils

Serious or Rare Side Effects

  • Allergic reactions, including anaphylaxis
  • Conjunctivitis and keratitis
  • Herpes zoster
  • Joint pain and mobility issues
  • Elevated liver enzymes

Precautions & Warnings

Dupixent should be used with caution and under the guidance of a healthcare provider. Important precautions include:

  • Inform your healthcare provider about all medications you are taking, especially those that suppress the immune system.
  • Avoid using live vaccines while on Dupixent without medical advice.
  • Monitor for signs of allergic reactions or infections.
  • Use exactly as prescribed and do not shake the syringe before use.
  • Store at room temperature: Protect from light and do not freeze.

Avoid Interactions

Dupixent may interact with other medications, particularly those that affect the immune system. Major Interactions (Avoid):

  • Live vaccines: Avoid concurrent use due to potential reduced vaccine efficacy and increased risk of infection.
  • Biologic therapies: May increase the risk of infections when used together.

Moderate Interactions (Monitor Closely)

  • Systemic corticosteroids: Monitor for signs of infection or reduced efficacy.
  • Other immunosuppressants: Increased risk of infections and other immune-related side effects.

Frequently Asked Questions

Dupixent 200 mg/1.14mL is used to treat moderate-to-severe atopic dermatitis (eczema), asthma, and chronic rhinosinusitis with nasal polyps. It works by targeting specific pathways involved in inflammation, helping to reduce symptoms and improve quality of life.

Dupilumab, the active ingredient in Dupixent, binds to the IL-4Rα subunit, blocking the signaling of interleukins 4 and 13. This action reduces type 2 inflammatory responses, which are involved in conditions like atopic dermatitis, asthma, and chronic rhinosinusitis with nasal polyps.

The dosage of Dupixent is determined by a healthcare provider based on the patient's condition, age, and weight. It is typically administered as a subcutaneous injection, with the specific dosing regimen prescribed by the doctor.

The safety of Dupixent during pregnancy or breastfeeding has not been fully established. It is important to consult with a healthcare provider to discuss the potential risks and benefits before using Dupixent in these situations.

To order Dupixent from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets and will ask the buyer to confirm trade or institutional credentials. The team will then provide pricing, availability, shipping, and the necessary import paperwork.

Dupixent is a biologic therapy that targets specific inflammatory pathways, making it effective for moderate-to-severe atopic dermatitis. Compared to topical treatments, it offers a systemic approach that can be more effective for widespread or severe symptoms. However, the choice of treatment depends on individual patient needs and should be discussed with a healthcare provider.

Dupixent should be stored at room temperature and protected from light. It is important not to shake the syringe before use. Always follow the instructions provided by your healthcare provider for proper administration and storage.

Dupixent is administered as a subcutaneous injection. It can be injected into the thigh, abdomen (except within 5 cm of the navel), or upper arm if administered by another person. The injection site should be rotated with each use, and the medication should not be injected into damaged or irritated skin.

The most serious risks associated with Dupixent include allergic reactions, such as anaphylaxis, and infections. Patients should be monitored for signs of infection or allergic reactions and should seek immediate medical attention if severe symptoms occur.

Dupixent should not be used by individuals with a known hypersensitivity to dupilumab or any of its components. It should also be used with caution in patients with a history of parasitic infections or those who are immunocompromised. Always consult a healthcare provider before starting Dupixent.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

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