Product image of Estradiol Valerate 40 mg/mL (Estradiol Valerate) 40 mg/mL INJECTION supplied by GNH India

Estradiol Valerate 40 mg/mL

Active Ingredient:
Estradiol Valerate
Form:
INJECTION
Brand:
Estradiol Valerate
Origin:
USA

Estradiol Valerate 40 mg/mL (Estradiol Valerate INJECTION) 40 mg/mL

Estradiol valerate, the active ingredient in Estradiol Valerate 40 mg/mL, is an estrogen presented as a 40 mg/mL injection for intramuscular use. It is used to treat symptoms of menopause, hypoestrogenism, and primary ovarian insufficiency in women. GNH India supplies Estradiol Valerate 40 mg/mL as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, pharmacies, and clinics worldwide.

Estradiol Valerate 40 mg/mL is a hormone replacement therapy that helps restore estrogen levels in the body. It is available in various strengths and formulations to meet different medical needs.

Strength

40 mg/mL

Pack Size

1 VIAL in 1 CARTON (0143-9291-01) / 5 mL in 1 VIAL

Manufacturer / TM Owner

Hikma Pharmaceuticals USA Inc.

1
Pack/s
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Indications & Clinical Uses

Estradiol Valerate 40 mg/mL is an estrogen therapy used to manage hormonal imbalances and related conditions.

  • Menopausal symptoms: Alleviates hot flashes, vaginal dryness, and other menopausal symptoms.
  • Hypoestrogenism: Treats conditions caused by low estrogen levels, such as primary ovarian insufficiency.
  • Estrogen replacement therapy: Restores estrogen levels in women with hormonal deficiencies.

How It Works

  • Estradiol valerate binds to estrogen receptors (ERα and ERβ) and modulates the transcription of estrogen-responsive genes, restoring estrogenic activity in target tissues. It acts through nuclear receptors in estrogen-responsive tissues, reducing elevated levels of gonadotropins, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) through a negative feedback mechanism.

Side Effects

Estradiol Valerate 40 mg/mL may cause various side effects, ranging from common to serious.

Common Side Effects

  • Nausea and vomiting.
  • Breast tenderness or swelling.
  • Headache.
  • Bloating.
  • Fluid retention.
  • Changes in menstrual bleeding patterns.

Serious or Rare Side Effects

  • Increased risk of blood clots.
  • Stroke or heart attack.
  • Liver dysfunction.
  • Gallbladder disease.
  • Increased risk of certain cancers, such as breast cancer.

Precautions & Warnings

Estradiol Valerate 40 mg/mL should be used with caution and under medical supervision.

  • Avoid use during pregnancy: Estradiol Valerate should not be used during pregnancy unless clearly needed.
  • Breast cancer history: Avoid use in women with a history of breast cancer.
  • Liver disease: Use with caution in patients with liver dysfunction.
  • Blood clots: Avoid use in patients with a history of blood clots.
  • Heart disease: Use with caution in patients with a history of heart disease.
  • Store at 2-8°C: Keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Estradiol Valerate 40 mg/mL may interact with other medications, potentially affecting its efficacy or increasing the risk of side effects.

Major Interactions (Avoid)

  • Anticoagulants: Increased risk of bleeding.
  • Tamoxifen: May reduce the effectiveness of tamoxifen.
  • Cytochrome P450 inducers: May decrease estradiol levels.

Moderate Interactions (Monitor Closely)

  • Anticonvulsants: May alter estradiol metabolism.
  • Antidepressants: May increase the risk of side effects.
  • Thyroid hormones: May affect thyroid hormone levels.

Frequently Asked Questions

Estradiol Valerate 40 mg/mL is used to treat symptoms of menopause, such as hot flashes and vaginal dryness, as well as conditions caused by low estrogen levels, including primary ovarian insufficiency. It is also used as part of estrogen replacement therapy in women with hormonal deficiencies.

Estradiol valerate binds to estrogen receptors in the body, modulating the transcription of estrogen-responsive genes. This action restores estrogenic activity in target tissues and helps regulate the pituitary secretion of gonadotropins, luteinizing hormone (LH), and follicle-stimulating hormone (FSH).

The dosage of Estradiol Valerate 40 mg/mL is determined by a healthcare provider based on the patient's medical condition, response to treatment, and other factors. It is typically administered as an intramuscular injection, with the frequency and dose tailored to individual needs.

Estradiol Valerate should not be used during pregnancy unless clearly needed. It is important to consult a healthcare provider for advice on the use of Estradiol Valerate during breastfeeding, as the safety and potential risks need to be evaluated on a case-by-case basis.

To order Estradiol Valerate 40 mg/mL from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets and will ask the buyer to confirm trade or institutional credentials. The team will then reply with pricing, availability, shipping details, and the necessary import paperwork.

Estradiol Valerate is a long-acting estrogen therapy that is administered intramuscularly. It is similar to other estrogen therapies in its mechanism of action but may differ in dosing frequency and formulation. The choice between Estradiol Valerate and other estrogen therapies depends on individual patient needs and medical history.

Estradiol Valerate 40 mg/mL should be stored at 2-8°C, kept refrigerated, protected from light, and not frozen or shaken. Proper storage is essential to maintain the efficacy and safety of the medication.

Estradiol Valerate 40 mg/mL is administered as an intramuscular injection. The frequency and dose are determined by a healthcare provider based on the patient's medical condition and response to treatment.

The most serious risks associated with Estradiol Valerate include an increased risk of blood clots, stroke, heart attack, liver dysfunction, gallbladder disease, and certain cancers, such as breast cancer. Patients should be monitored closely for these potential risks.

Estradiol Valerate 40 mg/mL should not be used by women with a history of breast cancer, liver disease, blood clots, or heart disease. It is also contraindicated in women with undiagnosed abnormal genital bleeding or known or suspected estrogen-dependent neoplasia.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

References

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