Fragmin 7500 [iU]/.3mL (Dalteparin Sodium INJECTION) 7500 [iU]/.3mL

Fragmin 7500 [iU]/.3mL is an anticoagulant used to prevent and treat blood clots in various conditions. It is commonly used in the following scenarios:

• Deep Vein Thrombosis (DVT): Prevents the formation of blood clots in the deep veins, typically in patients undergoing surgery or prolonged immobility.
• Pulmonary Embolism (PE): Treats existing blood clots in the lungs and prevents further clot formation.
• Acute Coronary Syndrome: Prevents thromboembolic events in patients with conditions such as unstable angina or myocardial infarction.
• Post-Surgical Prophylaxis: Reduces the risk of clot formation after certain types of surgery, including abdominal surgery.

• Fragmin 7500 [iU]/.3mL works by enhancing the activity of antithrombin III, a natural substance in the body that inhibits clotting factors such as factor Xa and, to a lesser extent, thrombin (factor IIa). This action reduces the blood's ability to form clots, thereby preventing conditions like deep vein thrombosis and pulmonary embolism.

Fragmin 7500 [iU]/.3mL may cause various side effects, ranging from mild to severe. Common Side Effects:

• Injection site reactions, such as pain, swelling, or bruising.
• Mild back pain.
• Nausea or vomiting.
• Mild bleeding, such as nosebleeds or gum bleeding.

Serious or Rare Side Effects

• Severe bleeding, including stomach bleeding or bleeding in the brain.
• Allergic reactions, such as rash, itching, or difficulty breathing.
• Spinal or epidural hematomas, which can cause long-term or permanent paralysis, especially in patients receiving neuraxial anesthesia or undergoing spinal puncture.
• Changes in blood test results, including platelet levels.

Fragmin 7500 [iU]/.3mL should be used with caution in certain situations. Consult your healthcare provider before use. Avoid use in patients with:

• Active bleeding or a history of bleeding disorders.
• Severe liver or kidney disease.
• A history of heparin-induced thrombocytopenia (HIT).
• Known allergies to heparin, dalteparin sodium, or benzyl alcohol used as a preservative in some dosage forms.
• Endocarditis or other serious infections affecting the heart.
• A history of spinal puncture or use of epidural catheters.

Store below 30°C: Keep in a cool, dry place away from direct sunlight and out of reach of children.

Fragmin 7500 [iU]/.3mL may interact with other medications, potentially affecting its efficacy or increasing the risk of side effects. Major Interactions (Avoid):

• Other anticoagulants, such as warfarin or heparin, which can increase the risk of bleeding.
• Nonsteroidal anti-inflammatory drugs (NSAIDs), which can also increase the risk of bleeding.
• Antiplatelet drugs, such as aspirin or clopidogrel, which can enhance the anticoagulant effect.

Moderate Interactions (Monitor Closely)

• Certain antibiotics, such as tetracyclines, which can affect the anticoagulant effect.
• Drugs that affect liver enzymes, such as rifampin, which can alter the metabolism of Fragmin.