Product image of Hertraz 150 (Trastuzumab) 150mg Vials supplied by GNH India

Hertraz 150

Active Ingredient:
Trastuzumab
Form:
Vials
Brand:
Hertraz
Origin:
India

Hertraz 150 (Trastuzumab Vials) 150mg

Trastuzumab, the active ingredient in Hertraz 150, is a monoclonal antibody presented as a 150mg vial for intravenous use. It is used in the treatment of HER2-positive breast cancer and HER2-positive gastric cancer in adult patients. GNH India supplies Hertraz 150 as a licensed, GDP-compliant international pharmaceutical supplier serving oncology centres worldwide.

Hertraz 150 is indicated for patients whose tumours have HER2 overexpression or gene amplification, as determined by validated assay methods. The drug is administered under the supervision of healthcare professionals experienced in the use of cytotoxic chemotherapy.

Strength

150mg

Pack Size

1s

Storage

2-8°

Manufacturer / TM Owner

Biocon Biologics India Limited

1
Pack/s
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Indications & Clinical Uses

Hertraz 150 is used in the treatment of cancers that overexpress the HER2 receptor, a pathway involved in cell growth and division.

  • HER2-Positive Breast Cancer: Used in the treatment of HER2-positive breast cancer, either as monotherapy or in combination with other chemotherapy agents.
  • HER2-Positive Metastatic Gastric Cancer: Indicated for the treatment of HER2-positive metastatic adenocarcinoma of the stomach or gastroesophageal junction in combination with other chemotherapy agents.
  • Early Breast Cancer: Used in the treatment of HER2-positive early breast cancer to prevent disease recurrence.

How It Works

  • Trastuzumab binds to the extracellular domain of the HER2 receptor, inhibiting ligand-independent HER2 signalling and preventing the proteolytic cleavage of its extracellular domain. This action inhibits the proliferation of HER2-overexpressing cancer cells and mediates antibody-dependent cell-mediated cytotoxicity (ADCC), targeting HER2-overexpressing cells for destruction.

Side Effects

Hertraz 150 may cause various side effects, ranging from common to serious.

Common Side Effects

  • Fatigue
  • Nausea
  • Vomiting
  • Diarrhoea
  • Fever
  • Chills
  • Weakness
  • Headache

Serious or Rare Side Effects

  • Cardiac dysfunction, including heart failure
  • Infusion-related reactions, such as allergic reactions and anaphylaxis
  • Haematotoxicity, particularly neutropenia
  • Infections
  • Pulmonary adverse reactions, including interstitial lung disease

Precautions & Warnings

Hertraz 150 should be used with caution and under the supervision of a healthcare professional.

  • Pregnancy: Not recommended for use in pregnant women due to insufficient safety and efficacy data.
  • Breastfeeding: Breastfeeding should be avoided during Trastuzumab therapy.
  • Children: Not recommended for use in children below 18 years of age.
  • Cardiac Function: Regular monitoring of cardiac function is required during treatment.
  • Infusion Reactions: Patients should be monitored for infusion-related reactions.
  • Store at 2-8°C: Keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Hertraz 150 may interact with other medications, requiring careful monitoring or avoidance.

Major Interactions (Avoid)

  • Anthracyclines: Increased risk of cardiac dysfunction when used in combination.
  • Other HER2-targeted therapies: Avoid concurrent use due to potential for overlapping toxicities.

Moderate Interactions (Monitor Closely)

  • Chemotherapy agents: Monitor for increased toxicity when used in combination.
  • Immunosuppressants: Increased risk of infections.
  • Live vaccines: Avoid concurrent use due to potential for vaccine inefficacy or increased risk of infection.

Frequently Asked Questions

Hertraz 150 is used in the treatment of HER2-positive breast cancer and HER2-positive metastatic gastric or gastroesophageal junction adenocarcinoma. It is specifically indicated for patients whose tumours overexpress the HER2 receptor, as determined by validated assay methods.

Trastuzumab works by binding to the HER2 receptor on cancer cells, inhibiting the signalling pathways that promote cell growth and division. It also mediates antibody-dependent cell-mediated cytotoxicity (ADCC), which helps the immune system target and destroy HER2-overexpressing cancer cells.

The dosage of Hertraz 150 is determined by a healthcare professional based on the patient's condition, body weight, and response to treatment. The prescriber will set the appropriate dosing schedule, which may vary depending on the specific indication and treatment regimen.

Hertraz 150 is not recommended for use in pregnant women due to insufficient safety and efficacy data. Breastfeeding should be avoided during Trastuzumab therapy to prevent potential harm to the infant.

To order Hertraz 150 from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets. The team will ask you to confirm your trade or institutional credentials and will reply with pricing, availability, shipping (including cold-chain where relevant), and the necessary import paperwork.

Hertraz 150 is a monoclonal antibody that specifically targets the HER2 receptor. It is similar to other HER2-targeted therapies in its mechanism of action but may have different efficacy and safety profiles. The choice of therapy depends on the patient's specific condition, treatment history, and response to previous therapies.

Hertraz 150 should be stored at 2-8°C, refrigerated, and protected from light. It should not be frozen or shaken. The reconstituted solution is stable for 28 days when stored refrigerated and should be discarded after this period. The drug solution for infusion diluted in 0.9% Sodium Chloride for Injection may be stored at 2-8°C for up to 24 hours prior to use.

Hertraz 150 is administered via intravenous infusion by a healthcare professional. The infusion should be given slowly, and the patient should be monitored for any infusion-related reactions. The specific administration schedule and duration will be determined by the prescribing healthcare professional.

The most serious risks associated with Hertraz 150 include cardiac dysfunction, infusion-related reactions, haematotoxicity (particularly neutropenia), infections, and pulmonary adverse reactions. Patients should be closely monitored for these risks during treatment.

Hertraz 150 should not be used in children below 18 years of age, pregnant women, and those with a known hypersensitivity to Trastuzumab or any of its components. It should be used with caution in patients with pre-existing cardiac conditions and those who have received prior anthracycline or taxane therapy.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

References

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