Product image of Hertraz 440 (Trastuzumab) 440 mg Vials supplied by GNH India

Hertraz 440

Active Ingredient:
Trastuzumab
Form:
Vials
Brand:
Hertraz
Origin:
India

Hertraz 440 (Trastuzumab Vials) 440 mg

Trastuzumab, the active ingredient in Hertraz 440, is a humanized monoclonal antibody presented as a 440 mg vial for intravenous use. It is used to treat HER2-positive breast and gastric cancers in adult patients. GNH India supplies Hertraz 440 as a licensed, GDP-compliant international pharmaceutical supplier serving hospitals, oncology centers, and pharmacies worldwide.

Hertraz 440 is a targeted therapy designed to inhibit the HER2 receptor, which is overexpressed in certain types of cancer. This medication is part of a broader range of oncology treatments provided by GNH India to support global healthcare needs.

Strength

440 mg

Pack Size

1s

Storage

2-8°

Manufacturer / TM Owner

Biocon Biologics India Limited

1
Pack/s
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Indications & Clinical Uses

Hertraz 440 is indicated for the treatment of HER2-positive cancers, specifically targeting the human epidermal growth factor receptor 2 (HER2) pathway.

  • HER2-positive metastatic breast cancer: Used as monotherapy or in combination with other chemotherapy agents for patients who have received prior treatment.
  • HER2-positive early-stage breast cancer: Administered as adjuvant therapy to reduce the risk of cancer recurrence.
  • HER2-positive gastric or gastro-esophageal junction adenocarcinoma: Used in combination with other chemotherapy drugs for metastatic disease.

How It Works

  • Trastuzumab binds to the extracellular domain of the HER2 receptor, inhibiting downstream signaling and mediating antibody-dependent cellular cytotoxicity. This action prevents the proliferation of cancer cells that overexpress HER2, thereby slowing tumor growth and progression.

Side Effects

Hertraz 440 may cause various side effects, ranging from common to serious.

Common Side Effects

  • Fatigue
  • Nausea and vomiting
  • Diarrhea
  • Fever and chills
  • Headache
  • Rash
  • Joint and muscle pain

Serious or Rare Side Effects

  • Cardiac dysfunction, including congestive heart failure
  • Infusion-related reactions, such as anaphylaxis
  • Neutropenia and other hematotoxicity
  • Pulmonary adverse reactions
  • Infections

Precautions & Warnings

Hertraz 440 should be used with caution and under the supervision of a healthcare professional.

  • Cardiac monitoring: Regular cardiac function assessments are required due to the risk of cardiac dysfunction.
  • Infusion reactions: Patients should be monitored for signs of infusion-related reactions during and after administration.
  • Pregnancy: Avoid use during pregnancy unless the potential benefits outweigh the risks, as it may affect fetal development.
  • Breastfeeding: Women should avoid breastfeeding during treatment with trastuzumab.
  • Pediatric use: Not recommended for children below 18 years of age due to insufficient safety and efficacy data.
  • Storage: Store at 2-8°C: Keep refrigerated, protect from light, do not freeze or shake.

Avoid Interactions

Hertraz 440 may interact with other medications, requiring careful monitoring or avoidance.

Major Interactions (Avoid)

  • Anthracyclines: Increased risk of cardiac toxicity when used in combination with trastuzumab.
  • Other HER2-targeted therapies: Concurrent use may increase the risk of adverse effects.

Moderate Interactions (Monitor Closely)

  • Chemotherapy agents: May enhance the myelosuppressive effects of trastuzumab.
  • Immunosuppressants: Increased risk of infections when used together.
  • Medications metabolized by CYP450 enzymes: Potential for altered drug metabolism.

Frequently Asked Questions

Hertraz 440 is used to treat HER2-positive breast and gastric cancers. It is indicated for metastatic breast cancer, early-stage breast cancer, and HER2-positive gastric or gastro-esophageal junction adenocarcinoma. The medication is administered as an intravenous infusion and is part of a targeted therapy approach.

Trastuzumab works by binding to the HER2 receptor on cancer cells, inhibiting downstream signaling and mediating antibody-dependent cellular cytotoxicity. This action prevents the proliferation of cancer cells that overexpress HER2, thereby slowing tumor growth and progression. It is a targeted therapy designed to specifically attack cancer cells with HER2 overexpression.

The dosage of Hertraz 440 is determined by a healthcare professional based on the patient's condition, body weight, and response to treatment. The initial loading dose and subsequent maintenance doses are calculated according to the patient's specific needs. It is important to follow the prescribed dosage and administration schedule as directed by the healthcare provider.

Hertraz 440 should be avoided during pregnancy unless the potential benefits outweigh the risks, as it may affect fetal development. Women should avoid breastfeeding during treatment with trastuzumab. It is important to discuss the potential risks and benefits with a healthcare professional before starting treatment.

To order Hertraz 440 from GNH India, submit an enquiry on the product page at gnhindia.com with the required quantity. GNH India supplies hospitals, pharmacies, and procurement teams across international markets. The team will ask the buyer to confirm trade or institutional credentials and will reply with pricing, availability, shipping (including cold-chain where relevant), and the import paperwork.

Hertraz 440 is a humanized monoclonal antibody that specifically targets the HER2 receptor. It is similar to other HER2-targeted therapies in its mechanism of action but may have differences in efficacy, safety profile, and administration schedule. The choice of therapy depends on the patient's specific condition and response to treatment, as determined by a healthcare professional.

Hertraz 440 should be stored at 2-8°C, kept refrigerated, protected from light, and not frozen or shaken. The reconstituted solution should be used immediately and any unused portion must be discarded. It is important to follow the storage and handling instructions provided by the manufacturer to ensure the medication's effectiveness and safety.

Hertraz 440 is administered as an intravenous infusion by a healthcare professional. The initial loading dose is typically administered over 90 minutes, and subsequent doses may be administered over a shorter period if well tolerated. Patients should be monitored for infusion-related reactions during and after administration.

The most serious risks associated with Hertraz 440 include cardiac dysfunction, infusion-related reactions, neutropenia, and pulmonary adverse reactions. Regular cardiac monitoring and close observation for signs of infusion-related reactions are essential. Patients should report any unusual symptoms to their healthcare provider immediately.

Hertraz 440 is not recommended for children below 18 years of age and pregnant women due to insufficient safety and efficacy data. It should be used with caution in patients with pre-existing cardiac conditions and those who have had severe infusion-related reactions to trastuzumab or other monoclonal antibodies. Always consult a healthcare professional before starting treatment.

Published by

GNH India Pharmaceuticals Limited

Licensed pharmaceutical supplier

Last updated:

References

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